A comparative study of the effects of four treatment regimes on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland

Kenyon, Fiona; McBean, David; Greer, Andrew W.; Burgess, Charlotte G.S.; Morrison, Alison A.; Bartley, David J.; Bartley, Yvonne; Devin, L.; Nath, Mintu; Jackson, F.

doi:10.1016/j.ijpddr.2013.02.001

Cited by 57 publications

(63 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…within a herd, are promoted as a method of maintaining animal performance whilst reducing the selection of anthelmintic resistant nematodes [2]. However, until now, TST have been mostly evaluated in sheep [26][27][28][29][30][31] and few data are available to determine which parameters are useful in identifying cattle that would benefit most from anthelmintic treatment. Previously the anti-O.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

et al. 2014

View full text Add to dashboard Cite

Background: Gastrointestinal nematodes are an important cause of reduced performance in cattle. Previous studies in Europe showed that after anthelmintic treatment an average gain in milk production of around 1 kg per day/ cow can be expected. However, (1) these studies have mainly evaluated group-based anthelmintic treatments during the grazing season or at housing and (2) little is known about parameters affecting variations in the treatment response amongst cows. A better knowledge of such parameters could help to select animals that benefit most from treatment and thus lead to a more rational use of anthelmintics. Therefore, a randomized, non-blinded, controlled clinical trial was performed on 11 commercial dairy farms (477 animals) in Belgium, aiming (1) to study the effect of eprinomectin treatment at calving on milk production and (2) to investigate whether the milk yield response was related to non-invasive animal parameters such that these could be used to inform targeted selective treatment decisions. Results: Analyses show that eprinomectin treatment around calving resulted in an average (± standard error) increase of 0.97 (±0.41) kg in daily milk yield that was followed up over 274 days on average. Milk yield responses were higher in multiparous compared to primiparous cows and in cows with a high (4 th quartile) anti-O. ostertagi antibody level in a milk sample from the previous lactation. Nonetheless, high responses were also seen in animals with a low (1 st quartile) anti-O. ostertagi antibody level. In addition, positive treatment responses were associated with higher faecal egg counts and a moderate body condition score at calving (2 nd quartile).

show abstract

Section: Discussionmentioning

confidence: 99%

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The experimental design for this study has already been described by Kenyon et al [19]. Briefly, replicated field trials were conducted over five consecutive years (2006)(2007)(2008)(2009)(2010) at the Moredun Research Institute farm, near Edinburgh, Scotland.…”

Section: Field Studymentioning

confidence: 99%

“…In this study, we use a 5-year field trial [19] to estimate GHG emissions from naturally grazing lambs treated under one of four anthelmintic regimes aimed at controlling endemic helminth parasites under genuine field/farm conditions in Scotland.…”

Section: Introductionmentioning

confidence: 99%

Reduction in Greenhouse Gas Emissions Associated with Worm Control in Lambs

Kenyon

Dick²,

Smith³

et al. 2013

Agriculture

Self Cite

View full text Add to dashboard Cite

There are currently little or no data on the role of endemic disease control in reducing greenhouse gas (GHG) emissions from livestock. In the present study, we have used an Intergovernmental Panel on Climate Change (IPCC)-compliant model to calculate GHG emissions from naturally grazing lambs under four different anthelmintic drug treatment regimes over a 5-year study period. Treatments were either "monthly" (NST), "strategic" (SPT), "targeted" (TST) or based on "clinical signs" (MT). Commercial sheep farming practices were simulated, with lambs reaching a pre-selected target market weight (38 kg) removed from the analysis as they would no longer contribute to the GHG budget of the flock. Results showed there was a significant treatment effect over all years, with lambs in the MT group consistently taking longer to reach market weight, and an extra 10% emission of CO 2 e per kg of weight gain over the other treatments. There were no significant differences between the other three treatment strategies (NST, SPT and TST) in terms of production efficiency or cumulated GHG emissions over the experimental period. This study has shown that endemic disease control can contribute to a reduction in GHG emissions from animal agriculture and help reduce the carbon footprint of livestock farming.

show abstract

“…This can be achieved through maintaining an adequate pasture infection pressure or leaving some of the animals in the flock untreated. TST (targeted selective treatment) has been proposed as a method to reduce GIN infections in sheep and to limit the selective pressure that leads to anthelmintic resistance [43]. The downside of TST is that identification of the individual animals to be treated is required, and practitioners and farmers or veterinarians often consider this as unpractical.…”

mentioning

confidence: 99%

Suspected Resistance against Moxidectin in Sheep Strongylid Nematodes in Austria

Schoiswohl¹,

Hinney²,

Tichy³

et al. 2017

JPP

View full text Add to dashboard Cite

Loss of efficacy due to resistance development against anthelmintics in livestock parasites is a growing concern worldwide. The aim of the present study was to determine the efficacy of moxidectin, a frequently-used macrocyclic lactone, against gastrointestinal nematodes of sheep in Austria. Individual faecal samples were collected from 243 adult sheep from 16 flocks in Styria and Salzburg before deworming and egg excretion (EPG (eggs per gram) of faeces) was determined using a modified McMaster technique. The animals were randomly assigned to a treatment group which received 0.2 mg/kg of body weight of moxidectin (Cydectin ® , Zoetis Schweiz GmbH, Zürich, Switzerland), and an untreated control group. Fourteen days after deworming a FECRT (faecal egg count reduction test) for detection of anthelmintic resistance was performed. Before deworming, the infection rate for gastrointestinal strongylids was 94.7%, with EPG values of 0~5,800. The FECRT showed reduction rates between 93.08% and 99.78% and was sufficient in 15/16 flocks. The lower confidence interval was 70.0~100%. In 3/16 flocks this value was below the minimum for sufficient efficacy (70.0%, 79.0%, 85.0%), and in two flocks the value (90.0%) was near the limit. These results indicated a (suspected) reduced efficacy of moxidectin in 5/16 examined flocks.

show abstract

A comparative study of the effects of four treatment regimes on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland

Cited by 57 publications

References 28 publications

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

Reduction in Greenhouse Gas Emissions Associated with Worm Control in Lambs

Suspected Resistance against Moxidectin in Sheep Strongylid Nematodes in Austria

Contact Info

Product

Resources

About