Colchicine in Behçet Syndrome: A Longterm Survey of Patients in a Controlled Trial

Hamuryudan, Vedat; Hatemi, Gülen; Tascilar, Koray; Yurdakul, Sebahattin; Mat, Cem; Özyazgan, Yılmaz; Seyahi, Emire; Uğurlu, Serdal; Yazıcı, Hasan

doi:10.3899/jrheum.130847

Cited by 19 publications

(11 citation statements)

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“…In our study, the number of OU during the last three months was higher in patients who received mild therapies compared to in those who were treated with more intensive treatment choices. A less severe treatment protocol was especially associated with oral ulcer activity in female gender, explained by a milder disease course in them ( 17 , 23 ). Interestingly, the frequency of tooth brushing was also observed to be higher in females.…”

Section: Discussionmentioning

confidence: 99%

The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

et al. 2018

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ObjectiveThe aim of this study was to assess the contributing factors for oral ulcer activity in Behçet’s disease (BD).MethodsNinety-two patients with BD (F/M: 42/50, mean age: 38.7±10.02 years) participated in this cross-sectional study. Data regarding disease-related factors, smoking patterns, and self-reported dietary/non-dietary triggering factors for oral ulcer activity were collected by a questionnaire. Treatment protocol was categorized as mild and intensive groups associated with organ involvements.ResultsA mild treatment protocol was more common in females (52.4% vs 20%) than in males (p=0.002). During the last three months, the number of oral ulcers in female patients was higher in the mild treatment group (6.4±6.5) than in the intensive treatment group (3.3±4.9) (p=0.045). In patients with active oral ulcers (n=63), rate of being a non-smoker was also higher in females (86.7% vs 63.6%) than in males. Daily frequency of tooth brushing was 1.2±0.8 in patients with BD, and was higher in females (1.5±0.9 vs 0.9±0.6) (p=0.001). Stress and fatigue (78.3%) were reported as the most frequent triggering factors for oral ulcer presence in patients with BD. A total of 148 different dietary factors associated with oral ulcer presence were reported in the study.ConclusionA mild treatment protocol and being a non-smoker were found to be the contributing factors associated with oral ulcer activity in patients with BD. Being motivated for oral hygiene and being non-smokers were positive health behaviors observed in females. Irrespective of gender, stress and fatigue were defined as the most common self-reported triggering factors for oral ulcer presence in BD. In addition, the roles of some dietary factors were also reported.

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Section: Discussionmentioning

confidence: 99%

The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

et al. 2018

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“…Oral ulcer is the most common clinical manifestation of BD. In contrast to immunosuppressive agents, conventional treatments using topical medications and colchicine could not eliminate oral ulcer activity (13)(14)(15). Therefore, this condition may be a barrier to medication adherence in cases of mucocutaneous involvement.…”

Section: Introductionmentioning

confidence: 99%

Oral ulcer activity in Behcet’s disease: Poor medication adherence is an underestimated risk factor

et al. 2017

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Objective: The aim of this study was to evaluate the relationship between oral ulcer activity and medication adherence according to gender in Behçet's disease (BD) patients. Material and Methods:The study group included 330 BD patients (F/M: 167/163, mean age: 38.5±10.5 years). Oral ulcer activity and medication adherence were evaluated in the previous month. Medication adherence was evaluated using the 8-item Morisky Medication Adherence Scale (MMAS-8) having a score range of "0" to "8" with high scores indicating better adherence. Low adherence was defined as <6 points on MMAS-8.Results: Over half of the group had active oral ulcers (n=219, 66.4%) within the month preceding the visit. The number of oral ulcers was significantly higher in female patients with low medication adherence (2.39±3.24) than in the rest of the female group (1.28±2.05; p=0.023). Although a similar trend was also observed in male patients (2.14±3.3 vs. 1.81±2.31), a significant relationship was not observed (p=0.89). The frequency of medication intake per day was lower in patients with high medication adherence than in the rest of the study group (p=0.04). Conclusion:Low medication adherence is a hidden risk factor in the management of BD. Poor adherence was associated with oral ulcer activity in female BD patients.

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“…9,10,12,36 These patients are not aggressively treated, as their manifestations do not have mortality risk and do not lead to permanent damage compared with those with major organ involvement. 3,10,[37][38][39] The effect of age on mucocutaneous manifestations was shown with two different analyses in our study. MI score was found to be high in younger female BS patients with systemic involvement.…”

Section: Discussionmentioning

confidence: 57%

Moderation analysis exploring associations between age and mucocutaneous activity in Behçet’s syndrome: A multicenter study from Turkey

Mumcu

Yay

Karaçaylı

et al. 2020

The Journal of Dermatology

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The aim of the present study was to examine the effects of age on mucocutaneous activity by using moderation analysis in Behc ßet's syndrome (BS). In this cross-sectional study, 887 BS patients (female : male, 481:406; mean age, 38.4 AE 10.9 years) followed in 13 tertiary centers in Turkey were included. Mucocutaneous activity was evaluated by using the Mucocutaneous Index (MI) according to sex and disease course. Moderation analysis was performed to test the effect of age on mucocutaneous activity. A moderator variable is a third variable and affects the relationship between independent and outcome variables. Age was chosen as a potential moderator variable (interaction effect), MI score as the outcome variable and sex as an independent variable in the analysis. The moderation analysis tested the effects of age in three steps: whole BS patient group, patients without systemic involvement and those with systemic involvement. The moderation model was only significant in BS patients with systemic involvement (P = 0.0351), and a significant relationship was observed between female sex and MI score (P = 0.0156). In addition, the interaction plot showed that female patients had increased MI scores compared with male patients, especially in the 28-year-old age group (P = 0.0067). Moreover, major organ involvement was newly diagnosed in the majority of these young female BS patients. Our results suggest that the relationship between sex and mucocutaneous activity was moderated by age in the systemic involvement group. Also, increased mucocutaneous activity may be associated with new major organ involvement in young female BS patients with systemic involvement.

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Colchicine in Behçet Syndrome: A Longterm Survey of Patients in a Controlled Trial

Abstract: Continuous use of colchicine, even when initiated at an early disease stage, does not seem to decrease the use of immunosuppressives in the long term.

Cited by 19 publications

References 11 publications

The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

Oral ulcer activity in Behcet’s disease: Poor medication adherence is an underestimated risk factor

Moderation analysis exploring associations between age and mucocutaneous activity in Behçet’s syndrome: A multicenter study from Turkey

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