Association of Interleukin 1 Family with Systemic Sclerosis

Zhang, Li; Yan, Junwei; Wang, Yujie; Wan, Yanan; Wang, Bingxiang; Tao, Jin‐Hui; Chen, Bing; Li, Baozhu; Yang, Guo-Jun; Wang, Jing

doi:10.1007/s10753-014-9848-7

“…In vivo, IL-1, including IL-1a and IL-1b, is elevated in association with fibrosis in humans and mice, and appears to be indirectly profibrotic in animal models, acting by induction of other mediators [168,227]. A thoughtful recent study [228] asked whether IL1b may have a direct effect on fibroblasts in culture.…”

Section: Il-1mentioning

confidence: 99%

The cytokines of pulmonary fibrosis: Much learned, much more to learn

Luzina

¹

,

Todd

²

,

Sundararajan

³

et al. 2015

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“…It may participate in a network of IL-1 family members to regulate adaptive and innate immune responses. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting a protective effect against some autoimmune diseases or nonneoplastic diseases [16–24]. However, whether IL-38 plays a role in carcinogenesis or cancer growth is unclear.…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression

Takada

¹

,

Okamoto

²

,

Tominaga

³

et al. 2017

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Interleukin (IL)-38, a novel member of the IL-1 cytokine family, is homologous to IL-1 receptor antagonist (IL-1Ra) and IL-36Ra, and has been reported to act as an antagonist. IL-38 expression is found in tonsil, placenta, and spleen, and recent studies suggest an association between IL-38 and autoimmune diseases. However, whether IL-38 plays a role in carcinogenesis or cancer growth is unclear. In the present study, we identified increases in IL-38 expression by immunohistochemistry in multiple types of cancer cells. In the examination of 417 surgically resected primary lung adenocarcinomas, Fisher’s exact tests showed significant associations between high IL-38 expression and high tumor grades, an advanced T status, advanced N status, advanced stage, and the presence of pleural and vessel invasions. Survival analyses by the Kaplan-Meier method showed that patients with high expression of IL-38 had significantly shorter disease-free survival and shorter overall survival after surgery than patients with low expression of IL-38 (log-rank test: P = 0.0021 and P = 0.0035, respectively). Moreover, programmed cell death-ligand 1 (PD-L1)-positive cases showed higher expression of IL-38 than PD-L1-negative cases (Wilcoxon rank-sum test: P < 0.0001). In conclusion, IL-38 was expressed in tumor cells of various cancers, and IL-38 expression was associated with poor survival of lung adenocarcinoma patients. IL-38 may affect host immunity or the tumor microenvironment, and contribute to the progression of lung adenocarcinoma.

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“…In line with this, we found a significant positive correlation between serum IL-1b concentrations and DLCO in patients with limited disease (r = 0.23; P = 0.05; n = 73). Serum IL-1b concentration was significantly increased in patients with ILD, however, only in those with diffuse SSc subtype (n = 12 vs n = 11; 11 [7,16] vs 4 [1,7] pg mL À1 ; P = 0.03). Moreover, a higher proportion of patients with ILD were observed in the high serum IL-1b subset, with borderline significance (P = 0.07) ( Supplementary table 6).…”

Section: Serum Il-1b and Ssc Clinical Parametersmentioning

confidence: 85%

“…The IL‐1 superfamily members IL‐1α, IL‐1β and IL‐18 are acknowledged to play a role in the pathogenesis of fibrosis and autoimmune disease, including SSc . Most SSc studies, however, have been conducted in small and poorly described populations .…”

Section: Discussionmentioning

confidence: 99%

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis

Lin

¹

,

Vincent

²

,

Sahhar

³

et al. 2019

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Objectives Systemic sclerosis ( SS c) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SS c remains poorly understood, although studies have indicated a role for the innate immune response. Methods Here, we measured serum interleukin ( IL )‐1α, IL ‐1β and IL ‐18 levels in 105 SS c patients and 47 healthy controls ( HC ) and analysed them with respect to multiple clinical parameters. Results Serum IL ‐18 concentrations were significantly higher in SS c patients than in HC , while no significant differences in concentrations of IL ‐1α and IL ‐1β were observed between SS c and HC . In both SS c and HC serum, IL ‐1α and IL ‐1β were positively correlated, while in SS c, both cytokines negatively correlated with IL ‐18. Serum IL ‐18 was significantly negatively correlated with both carbon monoxide transfer coefficient ( KCO ) and diffusing capacity of the lungs for carbon monoxide ( DLCO ). Serum IL ‐1β was positively correlated with the modified Rodnan skin score ( mRSS ), particularly in patients with limited subtype. DLCO , KCO and tricuspid regurgitation ( TR ) velocity were significantly higher in patients with high serum IL ‐1β. Serum IL ‐1α was significantly lower in SS c patients with low KCO and positively correlated with KCO . SS c patients with high serum IL ‐1α concentrations were more likely to have digital ulcers. Conclusions Our data suggest that these IL ‐1 family cytokines may have different roles in the pathogenesis of SS c fibrotic complications.

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Association of Interleukin 1 Family with Systemic Sclerosis

Cited by 22 publications

References 42 publications

The cytokines of pulmonary fibrosis: Much learned, much more to learn

The cytokines of pulmonary fibrosis: Much learned, much more to learn

Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis

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