Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla

Verloh, Niklas; Haimerl, Michael; Zeman, Florian; Schlabeck, Mona; Barreiros, Ana Paula; Loss, Martin; Schreyer, A. G.; Stroszczynski, Christian; Fellner, Claudia; Wiggermann, Philipp

doi:10.1007/s00330-014-3108-y

Cited by 125 publications

(94 citation statements)

References 34 publications

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“…The recent report by Verloh et al [15] also focused on the usefulness of Gd-EOB-DTPAenhanced MRI to determine the hepatic functional reserve and the results are quite similar as ours; the uptake of Gd-EOB-DTPA in hepatocysts is strongly affected by liver function. In our study, we added on information about the interobserver reliability of the percentage enhancement as well, which shows substantial agreement.…”

Section: Discussionsupporting

confidence: 85%

Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves

Tanpowpong

Phewplung

2014

Asian Biomedicine

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Background: Gadolinium diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a developed agent with preferential uptake by hepatocytes. A rapid and specific hepatocyte uptake with biliary excretion was observed of approximately 50% of the injected dose. The amount of contrast uptake is thought to be related to reserve liver function. Objectives: To evaluate correlation between liver signal intensity in the hepatobiliary phase of Gd-EOB-DTPA and reserved liver function by using the model score for end-stage liver disease (MELD). Methods: All patients who underwent magnetic resonance (MR) imaging with Gd-EOB-DTPA were retrospectively collected. The patients with serum creatinine level higher than 1.5 mg/dL or patients without available data to estimate MELD score were excluded. Thirty-six patients were enrolled. A signal-to-noise ratio (SNR) in the liver parenchyma on a fat-suppressed three dimensional fast spoiled-gradient recalled echo sequence images before and 20 minutes after contrast injection were measured and calculated on PACS by two radiologists. The MELD score was determined and interobserver reliability was estimated. Results: Among 36 patients, we found a negative relationship between the percentage enhancement and the MELD score (P < 0.01, r = 0.545). The SNR at 20 minutes after Gd-EOB-DTPA injection also had a negative relationship with the MELD score with statistical significance (P < 0.01, r = 0.460). Interobserver reliability was 0.675. Conclusion:The percentage enhancement in hepatobiliary phase of Gd-EOB-DTPA can predict reserved liver function.

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Section: Discussionsupporting

confidence: 85%

Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves

Tanpowpong

Phewplung

2014

Asian Biomedicine

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“…After administration, both ICG and Gd-EOB-DTPA uptake into functional hepatocytes are dependent on the same transport mechanisms that are mediated by the organic anion transporters OATP1B1/B3 [7]. The temporary accumulation of Gd-EOB-DTPA in the liver leads to an enhancement of normal liver parenchyma, which may be used as an indicator for the quantitative evaluation of liver function [8][9][10][11]. Other studies have shown that estimations of total liver function using parenchymal enhancement of the liver may be improved by taking into account the respective liver volume (LV) [12,13].…”

Section: Introductionmentioning

confidence: 99%

Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry

et al. 2015

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• Measurement of T1 relaxation times in Gd-EOB-DTPA-enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA-enhanced MR relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA-enhanced MR relaxometry. • Gd-EOB-DTPA-enhanced MR relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index.

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“…Diffusion-weighted imaging (DWI) and magnetic resonance imaging (MRI) using gadoxetic acid (Gd-EOB-DTPA) have recently shown promise for the evaluation of segmental liver functional reserve [6][7][8][9][10][11]. DWI is based on the random Brownian motion of water molecules within the voxel.…”

Section: Introductionmentioning

confidence: 99%

Assessing liver function in patients with HBV-related HCC: a comparison of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI

et al. 2014

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Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla

Abstract: Hepatic uptake of Gd-EOB-DTPA is strongly affected by liver function. Relative enhancement during HBP in GD-EOB-DTPA MRI correlates with the MELD score. Assessment of relative enhancement may help improve treatment in routine clinical practice.

Cited by 125 publications

References 34 publications

Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves

Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves

Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry

Assessing liver function in patients with HBV-related HCC: a comparison of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI

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