The Fallopian Tube as the Origin of High Grade Serous Ovarian Cancer: Review of a Paradigm Shift

Reade, Clare J.; McVey, Ruaidhrí; Tone, Alicia A.; Finlayson, Sarah; McAlpine, Jessica N.; Fung-Kee-Fung, Michael; Ferguson, Sarah E.

doi:10.1016/s1701-2163(15)30659-9

Cited by 79 publications

(67 citation statements)

References 66 publications

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“…We chose to overestimate our possible complication rate as 3.8%; however this complication rate is what has been reported in the literature for hysterectomy only [12]. The pathological findings may have been underestimated, because they did not follow the standards for reporting [7].…”

Section: Discussionmentioning

confidence: 97%

“…Before this, in September 2011 the Society of Gynecologic Oncology of Canada released a position statement announcing that ''due to its cancer potential, physicians discuss the risks and benefits of bilateral salpingectomy with patients undergoing hysterectomy for any indication'' [6]. At present, the benefits of prophylactic salpingectomy are not known, but are only theoretical [7]. Thus, there may be an opportunity to decrease the morbidity and mortality of epithelial ovarian cancers by performing bilateral salpingectomy at the time of hysterectomy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Success and Complications of Salpingectomy at the Time of Vaginal Hysterectomy

Robert

Cenaiko

Sepandj

et al. 2015

Journal of Minimally Invasive Gynecology

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Success and Complications of Salpingectomy at the Time of Vaginal Hysterectomy

Robert

Cenaiko

Sepandj

et al. 2015

Journal of Minimally Invasive Gynecology

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“…51 Recent molecular characterization of clear cell, mucinous, or grade 1 (low-grade) tumors suggests that mutations in these histologies are different from those in highergrade tumors. [83][84][85] Ovarian cancer can be divided into types 1 and 2 based on these molecular alterations. Data suggest that serous tumors can be categorized as either low grade (most grade 1 serous tumors) or high grade (most grade 2 or 3 serous tumors).…”

Section: Histologic Subtypesmentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

299

233

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“…Fallopian tube tumors play a crucial role in the origin of ovarian cancer [5,6]. The notion of this phenomenon came from PFTC as it was noted in patients with BRCA-1 and BRCA-2 mutations after riskreducing salpingo-oophorectomy.…”

Section: Discussionmentioning

confidence: 99%

Incidental Fallopian Tube Adenocarcinoma Managed using Robotic Staging Surgery

Hh³

et al. 2016

Adv Robot Autom

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IntroductionPrimary fallopian tube tumors, which are rare gynecological malignancies that account for 0.14%-1.8% of genital malignancy, mainly affect women aged 40-65 years [1]. Diagnosing primary fallopian tube tumors is challenging, and case reports involving tumors managed using robot-assisted staging surgery are rare. However, we have reported here two cases with favourable prognoses of primary fallopian tube tumors managed using robot-assisted staging surgery. The robotic-assisted procedures using three robotic arms were performed with the patient in the lithotomy position under general anesthesia. A uterine manipulator was put in place, and a pneumoperitoneum was obtained. For setting of the robotic surgery, a 12 mm camera port was set 6 cm above the umbilicus, and 8 mm trocars were set 8 to 10 cm caudal-lateral to the scope for the side arms at each side of the patient, respectively. We placed a fenestrated bipolar forcep in left arm for electrocoagulation and a monopolar curved scissor in right arm for simultaneous cutting and electro-cauterization. A manually operated accessory trocar, which was set at 6 to 8 cm caudal-lateral to the left arm, was placed for lymph node extraction.The robotic arms were docked smoothly, and ascites was collected for cytological examination. The robotic surgery was performed with Endo Wrist instruments including monopolar curved scissors and fenestrated bipolar forceps. A grasper was used via the accessory port to assist in the surgical procedures. A survey of the operative field and evaluation of pelvic adhesion were performed. A frozen section of the suspected primary lesion was sent to confirm its malignancy prior to the main procedure. Surgical staging procedures including a total hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic retroperitoneal lymph node dissection, para-aortic lymph node dissection, appendectomy, omentectomy, peritoneal biopsies, and ascites cytology were performed. After the main procedures, the uterus was removed intact via the vagina, and transvaginal suturing was performed subsequently to close the vaginal cuff. After surgery, the dissected tissue was subjected to pathological examination. Case 1A 49-year-old woman visited the author's clinic for abnormal vaginal discharge. She had not had a previous surgery or any family history of ovarian malignancy. She had menarche at the age of 13 and has had a regular menstrual cycle since then. She had given birth to two children and had never had an abortion. A transvaginal ultrasound preformed in the clinic revealed ascites and a left adnexal heteroechoic mass, 7 × 3 cm. A P ap smear report revealed atypical glandular cells. On admission to the obstetrics and gynecology ward, an abdominal examination did not reveal anything significant; no abdominal palpable mass, abdominal pain or enlargement of lymph nodes were noted. A vaginal examination presented a free range of motion for the cervix with serosanguinous vaginal discharge but without palpable adnexal mass lesions. A pelvic CT scan show...

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The Fallopian Tube as the Origin of High Grade Serous Ovarian Cancer: Review of a Paradigm Shift

Cited by 79 publications

References 66 publications

Success and Complications of Salpingectomy at the Time of Vaginal Hysterectomy

Success and Complications of Salpingectomy at the Time of Vaginal Hysterectomy

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Incidental Fallopian Tube Adenocarcinoma Managed using Robotic Staging Surgery

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