Teat papillomatosis associated with bovine papillomavirus types 6, 7, 9, and 10 in dairy cattle from Brazil

Abstract

This study describes the clinical, histopathological, and virological characterization of teat papillomatosis from Brazilian dairy cattle herds. Four types of bovine papillomavirus were identified (BPV6, 7, 9, and 10); one of these (BPV7) is being detected for the first time in Brazilian cattle.

Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

“…In this report, we detected four novel putative BPV types that belonged to the three distinct genera Xi, Epsilon, and Dyoxipapillomavirus. These putative new types have low identity with BPVs 7, 8, 11, and 12 and the histopathological results indicate their potential for causing papillomatosis since the closest related types were previously linked to cutaneous papillomas [3,7,13,16,17,24,33,34]. Moreover, to our knowledge, this is the first description of a putative new type related to the new Dyoxipapillomavirus genus.…”

“…Although some BPVs have higher affinities to specific primers [23], in the present study the primer pair FAP59/64 was able to amplify bovine papillomavirus DNA from all known BPVs genera. Despite the lower level of sensitivity of these primers when compared to specific primers [23] they have been used in many studies, being an important tool to enlarge the knowledge of BPVs diversity and enabling the discovery of a broad range of novel BPVs [10][11][12][13]16].…”

“…Although numerous BPV types have been described and putative and new BPV types have identified in Brazilian cattle from distinct regions [13,[15][16][17][18], Brazil is an extensive territory encompassing unstudied regions, which comprise a low number of habitants and one of the largest cattle herd worldwide. In this context, the Amazon region is propitious for the discovery of novel strains because this region has one of the largest beef cattle herds in Brazil and, in addition, the Amazon biome has one of the largest biodiversities worldwide.…”

Papillomaviruses in ruminants: An update

“…In general, Xipapillomavirus are classified as epitheliotropic PVs (BPV3, BPV4 and BPV6); Deltapapillomavirus are associated with fibropapillomas and cutaneous papillomas (BPV1, BPV2, BPV13 and BPV14) as well as the urinary bladder (BPVs 1, 2, 13 and 14) (Borzacchiello & Roperto, ; Lunardi, Alfieri, et al., ; Roperto, Russo, et al., ). The Epsilonpapillomavirus genus (BPV5 and BPV8) is linked to cutaneous papillomas (Claus et al., ; Da Silva et al., , ; Tomita et al., ), and the Dyoxipapillomavirus genus was described in healthy skin swabs and has been linked to cutaneous papillomas in teat and body (Ogawa, Tomita, Okada, & Shirasawa, ; Savini, Gallina, Alberti, Müller, & Scagliarini, ; Tozato et al., ). BPV6, BPV7, BPV8, BPV9 and BPV10 are usually linked to benign squamous papilloma (showing varying degrees of hyperkeratosis or parakeratosis, with elongated digital‐like proliferation of the squamous epithelium) and fibropapillomas (besides BPV7) (Lunardi et al., ; Tozato et al., ).…”

“…Roperto, Russo, et al, 2016). The Epsilonpapillomavirus genus (BPV5 and BPV8) is linked to cutaneous papillomas (Claus et al, 2009;Da Silva et al, 2015Tomita et al, 2007), and the Dyoxipapillomavirus genus was described in healthy skin swabs and has been linked to cutaneous papillomas in teat and body (Ogawa, Tomita, Okada, & Shirasawa, 2007;Savini, Gallina, Alberti, M€ uller, & Scagliarini, 2016;Tozato et al, 2013). BPV6, BPV7, BPV8, BPV9 and BPV10 are usually linked to benign squamous papilloma (showing varying degrees of hyperkeratosis or parakeratosis, with elongated digital-like proliferation of the squamous epithelium) and fibropapillomas (besides BPV7) (Lunardi et al, 2016;Tozato et al, 2013).…”