2014
DOI: 10.1371/journal.pgen.1004133
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Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in C. elegans and Drosophila

Abstract: Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent gene activation represses the same targets in the absence of signaling. T-cell factors (TCFs) are transcription factors in the Wnt/ß-catenin pathway, which control numerous cell fate specification events in metazoans. The TCF transcriptional switch is mediated by many co-regulators that contribute to repression or activation of Wnt target genes. It i… Show more

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Cited by 34 publications
(50 citation statements)
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References 108 publications
(200 reference statements)
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“…Consistent with this observation, the end promoters contain binding sites for the maternal factors SKN-1, POP-1 and PAL-1 (Fig. 2, Table S1) (Bhambhani et al, 2014; Blackwell et al, 1994; Korswagen et al, 2000; Lei et al, 2009). Of these, SKN-1 accounts for the majority of input into end activation, as loss of skn-1 activity results in a failure of gut specification in 65–80% of embryos (Bowerman et al, 1992; Huang et al, 2007; Maduro et al, 2005b).…”
Section: Resultssupporting
confidence: 73%
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“…Consistent with this observation, the end promoters contain binding sites for the maternal factors SKN-1, POP-1 and PAL-1 (Fig. 2, Table S1) (Bhambhani et al, 2014; Blackwell et al, 1994; Korswagen et al, 2000; Lei et al, 2009). Of these, SKN-1 accounts for the majority of input into end activation, as loss of skn-1 activity results in a failure of gut specification in 65–80% of embryos (Bowerman et al, 1992; Huang et al, 2007; Maduro et al, 2005b).…”
Section: Resultssupporting
confidence: 73%
“…While POP-1-dependent repression of the end s occurs via POP-1 sites (alone), POP-1-dependent activation requires the nearby presence of conserved ‘Helper’ sites through which the POP-1/SYS-1 complex likely binds (Bhambhani et al, 2014; Robertson et al, 2014; Shetty et al, 2005). The end-1 promoter contains a nearby POP-1+Helper site (Fig.…”
Section: Resultsmentioning
confidence: 99%
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