Blu-ray disk lens as the objective of a miniaturized two-photon fluorescence microscope

Chung, Hsiang Yu; Kuo, Wen-Chuan; Cheng, Yu; Yu, Che‐Hang; Chia, Shih Hsuan; Lin, Cheng Yung; Chen, Jie Shin; Tsai, Huai Jen; Fedotov, A. B.; Иванов, А. А.; Желтиков, А. М.; Sun, Chi‐Kuang

doi:10.1364/oe.21.031604

Cited by 4 publications

(1 citation statement)

References 46 publications

(5 reference statements)

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“…Fiber tip scanning, as illustrated in Figure 5 b, is one popular transverse scan mechanism enabling distal scanning. Fiber tip scanning has been widely used in various imaging modalities [ 32 , 38 , 39 , 40 , 41 ]. To obtain a more compact scanner for microendoscopy applications, piezoelectric [ 32 , 42 , 43 , 44 ] excited actuators have been widely used to drive the mechanical resonance vibration of the fiber tips.…”

Section: Miniature Two-photon Microscopymentioning

confidence: 99%

MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging

Zhou

et al. 2023

Micromachines

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Over the last decade, two-photon microscopy (TPM) has been the technique of choice for in vivo noninvasive optical brain imaging for neuroscientific study or intra-vital microendoscopic imaging for clinical diagnosis or surgical guidance because of its intrinsic capability of optical sectioning for imaging deeply below the tissue surface with sub-cellular resolution. However, most of these research activities and clinical applications are constrained by the bulky size of traditional TMP systems. An attractive solution is to develop miniaturized TPMs, but this is challenged by the difficulty of the integration of dynamically scanning optical and mechanical components into a small space. Fortunately, microelectromechanical systems (MEMS) technology, together with other emerging micro-optics techniques, has offered promising opportunities in enabling miniaturized TPMs. In this paper, the latest advancements in both lateral scan and axial scan techniques and the progress of miniaturized TPM imaging will be reviewed in detail. Miniature TPM probes with lateral 2D scanning mechanisms, including electrostatic, electromagnetic, and electrothermal actuation, are reviewed. Miniature TPM probes with axial scanning mechanisms, such as MEMS microlenses, remote-focus, liquid lenses, and deformable MEMS mirrors, are also reviewed.

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Section: Miniature Two-photon Microscopymentioning

confidence: 99%

MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging

Zhou

et al. 2023

Micromachines

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Compact, low-cost Blu-Ray pickup-based digital holographic microscope

Grare

2023

Optics and Lasers in Engineering

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Chromatic confocal microscopy to rapidly reveal nanoscale surface/interface topography by position-sensitive detection

Zhuo

Hsu

Wang

et al. 2018

Applied Physics Letters

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This paper presents a confocal microscope for the rapid and noninvasive capture of three-dimensional (3D) images showing the surface/interface topography in a far-field configuration. The proposed microscope features a nanoscale optical ruler capable of performing fast depth measurements based on the chromatic aberration of microscope objectives. A diffraction grating and a position-sensitive detector were used to extract the spectral shift, which directly maps the height of the surface with a nanoscale resolution. Because neither the mechanical scanning nor the spectrometer, which limit the speed of 3D imaging, are needed in the axial direction, full 3D surface topography images with nanoscale depth resolution can be acquired rapidly using the nanoscale optical ruler in conjunction with 2D lateral beam scanning. The presented technique overcomes the limitation of the detection speed of conventional chromatic confocal microscopy. In experiments, the 3D static and dynamic nanoscale surface profiles of several representative optoelectronic and electronic devices were demonstrated. This fast and non-invasive approach with nanoscale depth resolution to the measurement of topography images has considerable promise in academic research and industrial applications.

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Blu-ray disk lens as the objective of a miniaturized two-photon fluorescence microscope

Cited by 4 publications

References 46 publications

MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging

MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging

Compact, low-cost Blu-Ray pickup-based digital holographic microscope

Chromatic confocal microscopy to rapidly reveal nanoscale surface/interface topography by position-sensitive detection

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