“…Many pathogenic mechanisms have been reported for LRRK2 mutations. Among those there is a growing number of evidence of involvement of LRRK2 in different vesicle trafficking events, including endocytosis [152,171], Golgi clearance [43,51,126,150,151], cytoskeleton dynamics [40-43, 53, 115, 126, 138, 139, 150, 172-174], lysosomal dynamics [143], and autophagy [124,140,142,146,175]. Different pathogenic LRRK2 mutations can cause alterations of at least some of these events.…”