Cholesterol and the “Cycle of Violence” in attempted suicide

Asellus, Peter; Nordström, Anna-Lena; Jokinen, Jussi

doi:10.1016/j.psychres.2014.01.009

Cited by 21 publications

(25 citation statements)

References 39 publications

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“…Unlike findings from other studies (Asellus et al, 2014;Paavola et al, 2002;Roaldset et al, 2011a), any inpatient or post-discharge associations between low levels of TC and violence were non-significant. The same goes for separate analysis of patients with the lowest levels of TC, and tests of the HDL/TC ratio.…”

Section: Clinical and Ethical Implicationscontrasting

confidence: 99%

“…A positive association between low levels of TC and violence has been found in most previous studies, e.g. in a meta-analysis of 32 studies with different design (Golomb, 1998), in a large community cohort study (Golomb et al, 2000), and in studies from different areas of psychiatry (Asellus et al, 2014;Paavola et al, 2002;Roaldset et al, 2011a). When it comes to HDL, results have been more conflicting.…”

Section: Introductionmentioning

confidence: 85%

“…A recent study of V-RISK-10 indicated that there may be gender differences concerning psychosocial risk factors of violence in acute psychiatry (Eriksen et al, 2016). In our literature search on studies of associations between different types of cholesterol and violence among psychiatric patients, we found only two studies that addressed gender differences (Asellus et al, 2014;Chen et al, 2015). Asselus and co-workers found no gender differences with respect to low TC levels as a risk marker of violence when examining association between exposure to childhood violence and violent behaviour as an adult.…”

Section: Introductionmentioning

confidence: 96%

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Low cholesterol level as a risk marker of inpatient and post-discharge violence in acute psychiatry – A prospective study with a focus on gender differences

Eriksen

Bjørkly

Lockertsen

et al. 2017

Psychiatry Research

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Several studies indicate an association between low levels of serum cholesterol and aggressive behaviour, but prospective studies are scarce. In this naturalistic prospective inpatient and post-discharge study from an acute psychiatric ward, we investigated total cholesterol (TC) and high-density lipoprotein (HDL) as risk markers of violence. From March 21, 2012, to March 20, 2013, 158 men and 204 women were included. TC and HDL were measured at admission. Violence was recorded during hospital stay and for the first 3 months post-discharge. Univariate and multivariate binary logistic regression were used to estimate associations between low TC and low HDL and violence. Results showed that HDL level was significantly inversely associated with violence during hospital stay for all patients. For men, but not for women, HDL level was significantly inversely associated with violence the first 3 months post-discharge. Results indicate that low HDL is a risk marker for inpatient and post-discharge violence in acute psychiatry and also suggest gender differences in HDL as a risk marker for violence.

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Section: Clinical and Ethical Implicationscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 96%

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Low cholesterol level as a risk marker of inpatient and post-discharge violence in acute psychiatry – A prospective study with a focus on gender differences

Eriksen

Bjørkly

Lockertsen

et al. 2017

Psychiatry Research

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“…Subjects with the s allele of serotonin transporter gene 5-HTTLPR polymorphism are over-represented among suicide attempters [28] and have lower LDL cholesterol [29]. An association of suicidal behavior with 5-HTTLPR polymorphism was observed in subjects with childhood trauma [30], which corresponds with the results of a study showing a significant correlation between exposure to violence as a child and adult violence in patients with low serum cholesterol [31]. …”

Section: Discussionmentioning

confidence: 67%

Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

Ainiyet¹,

Rybakowski

2014

Med Sci Monit

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BackgroundLifetime suicide mortality in people with schizophrenia is approximately 4–5%, which is higher than in the general population. In mood disorders, many studies and meta-analyses have shown a link between suicidal behavior and low lipid levels, especially that of cholesterol, and some studies have also suggested such a relationship in schizophrenia. Therefore, the aim of the present study was to investigate a possible correlation between suicidal behavior and lipid levels in schizophrenia patients recently admitted to a psychiatric hospital.Material/MethodsOur study included 148 (69 males, 79 females) schizophrenia patients with a mean age of 32±10 years, all recently admitted due to acute exacerbation of their mental illness. Psychometric and laboratory assessments were made within 24–72 hours after hospital admission. The main purpose of the interview was to assess occurrence of any suicidal thoughts, suicidal tendencies, and/or suicide attempts during the 3 months prior to admission. Serum total, LDL and HDL cholesterol, as well as triglycerides and total lipids were measured.ResultsA significant association was found between suicidal thoughts and attempts and low total cholesterol, LDL cholesterol, triglycerides, and total lipids, in both male and female patients. In male patients with suicidal tendencies, correlation with low LDL cholesterol and triglycerides did not reach statistical significance. No association with suicidality was found with HDL cholesterol in subjects studied.ConclusionsThe results obtained suggest that, similar to depressed patients, low total and LDL cholesterol, triglycerides, and total lipids can be state-dependent risk factors for suicidal behavior in Polish patients with schizophrenia.

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“…Interest in the interface between psychological variables and cholesterol levels has focused mainly on the context of mood and anxiety disorders[4] and suicide. [5]…”

Section: Introductionmentioning

confidence: 99%

The Importance of Cholesterol in Psychopathology: A Review of Recent Contributions

Pereira

2017

Indian Journal of Psychological Medicine

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Aim:The aim of this study was to describe systematically recent studies that show the importance of cholesterol in psychopathology.Methods:This study was a review. The following databases were searched for relevant published articles on human studies: MEDLINE, Web of Science, EBSCOhost Academic Search Complete, and Psychology and Behavioral Sciences Collection (papers from January 2012 to March 2016).Results:Eighteen recent papers were selected, and thematic dimensions showing correlations between cholesterol and behavioral and psychopathological variables were depression, suicide, personality, and aggression.Conclusion:This paper demonstrates that recent research corroborates the idea that cholesterol plays an important role in governing behavior and psychopathology in humans. Deepening the studies in this field could be a promising avenue for future research, with implications for treating people with behavior or mental health problems.

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Cholesterol and the “Cycle of Violence” in attempted suicide

Cited by 21 publications

References 39 publications

Low cholesterol level as a risk marker of inpatient and post-discharge violence in acute psychiatry – A prospective study with a focus on gender differences

Low cholesterol level as a risk marker of inpatient and post-discharge violence in acute psychiatry – A prospective study with a focus on gender differences

Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

The Importance of Cholesterol in Psychopathology: A Review of Recent Contributions

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