245 Evidence for a New Mechanism Underlying Persistent Visceral Hypersensitivity and Increased Permeability in a Model of Post-Infectious IBS

Aguilera‐Lizarraga, Javier; Mondelaers, Stéphanie; Florens, Morgane; Balemans, Dafne; Theofanous, Stavroula; Perna, Eluisa; Wouters, Mira M.; Boeckxstaens, Guy E.

doi:10.1016/s0016-5085(15)30190-6

Cited by 4 publications

(3 citation statements)

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“…If true, VHS will only develop upon re‐exposure to these innocent bystander antigens, possibly explaining why no persistent VHS is observed in our current study. Preliminary data seem to support this hypothesis, but further experiments are clearly required.…”

Section: Discussionmentioning

confidence: 95%

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium‐infected mice

Mondelaers

Theofanous

Florens

et al. 2016

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 95%

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium‐infected mice

Mondelaers

Theofanous

Florens

et al. 2016

Neurogastroenterology Motil

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“…Both biopsy and fecal supernatants from IBS patients impair barrier in vitro , suggesting a role of peripheral mediators. The exact mediators and their mechanism of action have yet to be fully unraveled, but food antigens, 128 proteases, 81 , 99 , 102 bile acids 129 and short-chain fatty acids 130 are among the top targets. The recent development of humanized animal models as well as organoids provides unique platforms to study the effects of specific patient-derived mediators on host environment that more closely resemble the complexity of humans.…”

Section: Discussionmentioning

confidence: 99%

Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

Hanning

Edwinson

Ceuleers

et al. 2021

Therap Adv Gastroenterol

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Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

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“…Of note, all individuals reported symptom improvement and immune activation markers returned to normal 6 months after initiation of a diet free of wheat and related cereals . To what extent similar mechanisms also play a role in IBS and whether genetically predisposed individuals may become sensitized to food and microbial antigens during an acute insult of the intestinal barrier (e.g., during an infectious gastroenteritis, inflammation, or an episode of stress) remains to be established …”

Section: Perspectivesmentioning

confidence: 98%

Neuroimmune factors in functional gastrointestinal disorders: A focus on irritable bowel syndrome

Boeckxstaens

Wouters

2016

Neurogastroenterology Motil

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This review discusses the potential mechanisms underlying aberrant neuroimmune interactions in peripheral sensitization of sensory nerves. A better understanding of the cells, mediators, and molecular mechanisms triggering persistent aberrant neuroimmune interactions brings new insights into their contribution to the physiology and pathophysiology of visceral pain perception and provides novel opportunities for more efficient therapeutic treatments for these disorders.

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245 Evidence for a New Mechanism Underlying Persistent Visceral Hypersensitivity and Increased Permeability in a Model of Post-Infectious IBS

Cited by 4 publications

References 0 publications

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium‐infected mice

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium‐infected mice

Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

Neuroimmune factors in functional gastrointestinal disorders: A focus on irritable bowel syndrome

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