Familial Clustering of Type 2 Diabetes among Omanis

Al-Sinani, Siham; Al-Shafaee, Mohammed; Al-Mamari, Ali; Woodhouse, Nicholas; Al-Shafie, Omaima; Hassan, Mohammed O.; Al‐Yahyaee, Said; Albarwani, Sulayma; Jaju, Deepali; Al-Hashmi, Khamis; Abri, Mohammed Al; Rizvi, Syed; Bayoumi, Riad

doi:10.5001/omj.2014.11

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…[1][2][3] The impact of this non-communicable disease -in terms of its diagnosis and management by different levels of health care providers -has made measurement of glucose among the most commonly requested core biochemistry test worldwide both as laboratorybased or point-of-care testing. Accurate measurement of glucose in blood, plasma, or serum is required for the diagnosis, treatment and assessment of diabetes mellitus.…”

mentioning

confidence: 99%

Are Tubes Containing Sodium Fluoride Still Needed for the Measurement of Blood Glucose in Hospital Laboratory Practice?

Al-Kharusi¹,

Al-Lawati²,

Al-Kindi³

et al. 2014

Oman Med J

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mentioning

confidence: 99%

Are Tubes Containing Sodium Fluoride Still Needed for the Measurement of Blood Glucose in Hospital Laboratory Practice?

Al-Kharusi¹,

Al-Lawati²,

Al-Kindi³

et al. 2014

Oman Med J

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“…An increased risk of T2DM has been observed among the offspring of such consanguineous marriages in Saudi Arabia and Qatar (47, 48). The familial clustering of T2DM has been reported in Arab populations from Morocco (49), Tunisia (50), Oman (51), and Qatar (52). Additionally, Arab populations exhibit many rare, Mendelian, and familial genetic disorders.…”

Section: Possible Causes For Observed Differences In the Risk Loci Prmentioning

confidence: 98%

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations

et al. 2019

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Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an increased risk for metabolic disorders. Unlike the European population, the Arab population lacks well-established genetic risk determinants for metabolic disorders, and the transferability of established risk loci to this population has not been satisfactorily demonstrated. The most recent findings have identified over 240 genetic risk loci (with ~400 independent association signals) for type 2 diabetes, but thus far only 25 risk loci (ADAMTS9, ALX4, BCL11A, CDKAL1, CDKN2A/B, COL8A1, DUSP9, FTO, GCK, GNPDA2, HMG20A, HNF1A, HNF1B, HNF4A, IGF2BP2, JAZF1, KCNJ11, KCNQ1, MC4R, PPARγ, SLC30A8, TCF7L2, TFAP2B, TP53INP1, and WFS1) have been replicated in Arab populations. To our knowledge, large-scale population- or family-based association studies are non-existent in this region. Recently, we conducted genome-wide association studies on Arab individuals from Kuwait to delineate the genetic determinants for quantitative traits associated with anthropometry, lipid profile, insulin resistance, and blood pressure levels. Although these studies led to the identification of novel recessive variants, they failed to reproduce the established loci. However, they provided insights into the genetic architecture of the population, the applicability of genetic models based on recessive mode of inheritance, the presence of genetic signatures of inbreeding due to the practice of consanguinity, and the pleiotropic effects of rare disorders on complex metabolic disorders. This perspective presents analysis strategies and study designs for identifying genetic risk variants associated with diabetes and related traits in Arab populations.

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“…There is a significant increase in the number of Omanis registered with DM and diabetic retinopathy in Oman in the past two decades [ 29 ]. Most of the Omani families have at least one of the parents with diabetes and having the risk of developing diabetes with at least one complication—high blood pressure, coronary artery disease, or retinopathy [ 30 , 31 ].…”

Section: Review Of Literaturementioning

confidence: 99%

Analytical Data Review to Determine the Factors Impacting Risk of Diabetes in North Al-Batinah Region, Oman

Yousif

Khan

Zia

et al. 2021

IJERPH

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Diabetes is one of the most widespread diseases resulting in an increase in mortality rate, and negatively affecting Oman’s economy. In 2019, an estimated 1.5 million deaths were directly caused by diabetes world health organization (WHO). The total number of diabetes cases among Omanis aged between 20 and 79 in 2015 is about 128,769, which increased in 2020 to 149,195. However, the total forecast number of diabetes cases will double in 2050 to 352,156. The healthcare spend on diabetes is 16.6%, which has triggered the need for the study. This research aims to review and analyze the prevailing situation around diabetes in Oman and its risk factors using multilinear regression tests, ANOVA, and descriptive analysis. Two hundred and fourteen samples were collected through a well-defined questionnaire using the purposive sampling technique. The study’s empirical results reveal that females, who were 79% of the respondents, have at least one of their family members as a diabetes patient; 41% of the respondents were affected by Type-2 (T2-DM) diabetes, and 38% were unaware of their type of diabetes. While, 91% of them were undergoing medication. The study indicates the risk factors that impact the diabetes number and type in North Oman, which include Aage with a rate of (0.595), followed by family history (0.560), smoking habits (0.530), and being overweight (0.435). Age plays an important role in the type of diabetes of the patients, and the types of diabetes impacts medication type. The type of diabetes has influenced the frequency of diabetes patients’ self-testing at home. Overall, 92% were rushed to the hospital or took medication immediately in case of a considerable variation in the readings; and 68% of the respondents complained that visiting the hospital is a costly affair and the health service is deteriorating.

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Familial Clustering of Type 2 Diabetes among Omanis

Cited by 8 publications

References 27 publications

Are Tubes Containing Sodium Fluoride Still Needed for the Measurement of Blood Glucose in Hospital Laboratory Practice?

Are Tubes Containing Sodium Fluoride Still Needed for the Measurement of Blood Glucose in Hospital Laboratory Practice?

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations

Analytical Data Review to Determine the Factors Impacting Risk of Diabetes in North Al-Batinah Region, Oman

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