Association between passive smoking and atopic dermatitis in dogs

Ka, Diane; Marignac, Geneviève; Desquilbet, Loïc; Freyburger, Ludovic; Hubert, B.; Garelik, D.; Perrot, S.

doi:10.1016/j.fct.2014.01.015

Cited by 17 publications

(12 citation statements)

References 27 publications

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“…To date, most studies have been performed in humans. However, more recent studies have specifically investigated the impact of environmental factors on the immune response in dogs . Further studies investigating the potential of environmental interactions with the innate immune system to influence and modulate canine AD will be important.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, other studies have found strong evidence of an association between AD and environmental exposure to tobacco smoke, especially when combined with maternal PM exposure . One study in dogs reported an increased rate of allergic skin disease in dogs with very high levels of environmental smoke exposure compared with unexposed dogs …”

Section: Environmental Contributions To Atopic Dermatitismentioning

confidence: 96%

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Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis

Bizikova

Pucheu‐Haston

Eisenschenk³

et al. 2015

Veterinary Dermatology

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It is becoming clear that canine AD is genotypically complex and influenced by a variety of environmental factors. Well-designed studies with sufficient statistical power will be critical to identify the complex genetic and environmental factors involved in disease development and progression. Recognition of such factors may help to identify new targets for therapy and enable better disease prevention and management.

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Section: Discussionmentioning

confidence: 99%

Section: Environmental Contributions To Atopic Dermatitismentioning

confidence: 96%

Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis

Bizikova

Pucheu‐Haston

Eisenschenk³

et al. 2015

Veterinary Dermatology

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“…Canine atopic dermatitis (CAD) affects up to 10% of dogs [1] and it is described as a genetically predisposed inflammatory and pruritic dermatitis with characteristic features related to IgE antibodies usually directed against environmental allergens [2]. Atopic dermatitis (AD) in both humans and dogs is influenced by both genetic and environmental factors as the aetiopathogenesis is very complex [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

2017

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The aim of this cross-sectional study was to observe whether environmental factors and phenotypic traits are associated with owner-reported skin problems and with veterinary diagnosed canine atopic dermatitis (CAD). Data were collected using the validated online DOGRISK questionnaire. Out of the data that the questionnaire provides for analysis, focus was first turned towards addressing questions regarding ‘Atopy/allergy (skin symptoms)’ using a total of 8643 dogs: 1585 dogs with owner-reported allergic/atopic skin symptoms and 7058 dogs without. A subsequent analysis compared dogs with veterinary-verified CAD (n = 322) as a case group against the 7058 dogs without owner-reported skin symptoms. The association between 21 factors related to the environment, canine phenotypes and breed groups within both populations were analysed using univariable and multivariable logistic regression. The environmental factors that showed a significant inverse association with the risk of owner-reported allergic/atopic skin symptoms were as following: whether the dog was living in a detached house, whether there were other dogs in the household, and whether the dog was born in the current household. Having over 50% white colour in the coat and living in an extremely clean household were significantly associated with an increased risk of owner-reported allergic/atopic skin symptoms. The five breeds demonstrating the highest proportion of owner-reported allergic/atopic skin symptoms were West Highland white terrier, Boxer, English bulldog, Dalmatian and French bulldog. The Fédération Cynologique Internationale dog breed groups 3 (Terriers) and 6 (Scent hounds and related breeds) showed a significantly higher risk for owner-reported allergic/atopic skin symptoms than mixed breed dogs. In the second population, the inverse association was observed between the risk of CAD and the presence of other dogs in the household, and whether the dog had been born in the current household. The results indicate that some environmental factors and canine phenotypes are associated with CAD and owner-reported skin symptoms, but they still do not prove causality.

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“…The pets, particularly the dogs and cats, are of particular interest, given that they share the habitat with humans and they respond to toxic assaults similar to their owners (Backer et al 2001). Thus, many studies have been designed to reveal the shared exposure of humans and dog/cats to different environmental toxicants of anthropogenic origin, such as asbestos (Glickman et al 1983;Backer et al 2001), tobacco smoke (Ka et al 2014), industrial pollutants (Maciejewski et al 2008;Bischoff et al 2010), pesticides (Knapp et al 2013) or smog (Heyder & Takenaka 1996;Calderon-Garciduenas et al 2001), among others. Most of these studies have found associations between exposure and elevation of the selected biomarkers, as well as correlations between the incidence of diseases related to exposure to such pollutants between pets and humans.…”

Section: Introductionmentioning

confidence: 99%

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Ruiz-Suárez

Rial

Boada

et al. 2015

Journal of Applied Animal Research

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Several studies have shown that pet dogs and cats, since they share the habitat with people, could be good sentinels for human exposure to environmental pollutants. However, some publications have suggested that dogs could efficiently metabolize and eliminate some persistent organic pollutants (POPs), which are accumulated by humans throughout life. For this reason, the role of domestic dogs as sentinels could not be appropriate, at least for certain contaminants. To test this hypothesis, we designed this study in which we determined plasma levels of 56 POPs (11 organochlorine pesticides [OCPs], 18 polychlorinated biphenyls [PCBs] and 27 polycyclic aromatic hydrocarbons) in the plasma of 87 dogs and 100 people from the same area (the Canary Islands, Spain). We detected most of these contaminants in the plasma of both species, although the frequencies of detection, concentrations and profiles were very different from each other, especially for ∑OCPs and ∑PCBs. In light of these results, we can conclude that, although they share the environment, sources of exposure to these pollutants and/or the metabolic capabilities do not seem to be comparable between the two species, so that the dog does not seem to be a good sentinel for human exposure to these contaminants.

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Association between passive smoking and atopic dermatitis in dogs

Cited by 17 publications

References 27 publications

Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis

Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

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