Relationship between Sun Exposure and Kidney Cancer: Preliminary Experience with the Evaluation of Recreational UV Exposure

Grasso, Antonietta; Blanco, Salvatore; Fantini, Gemma; Torelli, F.; Grasso, Marco

doi:10.5301/urologia.5000036

Cited by 1 publication

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“…With regard to data collection and analysis, an accurate, clinically-useful tool should rapidly parse residential histories, including the durations of residence, and link them to UV indices, as all these factors can vary significantly across a lifetime [ 20 , 22 , 23 ]. Individuals living in the United States frequently change their geographic region of residence over their lifetimes, with over one-third of the population residing in a state different than the one they were born in [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool

Zhu

Raber

Sakshuwong³

et al. 2016

BMC Dermatol

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BackgroundEstimates of an individual’s cumulative ultraviolet (UV) radiation exposure can be useful since ultraviolet radiation exposure increases skin cancer risk, but a comprehensive tool that is practical for use in the clinic does not currently exist.The objective of this study is to develop a geographically-adjusted tool to systematically estimate an individual’s self-reported cumulative UV radiation exposure, investigate the association of these estimates with skin cancer diagnosis, and assess test reliability.MethodsA 12-item online questionnaire from validated survey items for UV exposure and skin cancer was administered to online volunteers across the United States and results cross-referenced with UV radiation indices. Cumulative UV exposure scores (CUES) were calculated and correlated with personal history of skin cancer in a case–control design. Reliability was assessed in a separate convenience sample.Results1,118 responses were included in the overall sample; the mean age of respondents was 46 (standard deviation 15, range 18 – 81) and 150 (13 %) reported a history of skin cancer. In bivariate analysis of 1:2 age-matched cases (n = 149) and controls (n = 298), skin cancer cases were associated with (1) greater CUES prior to first skin cancer diagnosis than controls without skin cancer history (242,074 vs. 205,379, p = 0.003) and (2) less engagement in UV protective behaviors (p < 0.01). In a multivariate analysis of age-matched data, individuals with CUES in the lowest quartile were less likely to develop skin cancer compared to those in the highest quartile. In reliability testing among 19 volunteers, the 2-week intra-class correlation coefficient for CUES was 0.94. We have provided the programming code for this tool as well as the tool itself via open access.ConclusionsCUES is a useable and comprehensive tool to better estimate lifetime ultraviolet exposure, so that individuals with higher levels of exposure may be identified for counseling on photo-protective measures.Electronic supplementary materialThe online version of this article (doi:10.1186/s12895-016-0038-1) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool

Zhu

Raber

Sakshuwong³

et al. 2016

BMC Dermatol

View full text Add to dashboard Cite

show abstract

Relationship between Sun Exposure and Kidney Cancer: Preliminary Experience with the Evaluation of Recreational UV Exposure

Abstract: Recreational sunlight exposure does not differ in our cohorts of patients and controls; studies on greater cohorts are needed to evaluate the effect of recreational sun exposure in the development of kidney cancer.

Cited by 1 publication

References 31 publications

Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool

Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool

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