Investigation of the application of phase contrast imaging using a point X-ray source to industrial non-destructive testing

Suzuki, Kazuaki; Haig, Ian

doi:10.1098/rsta.2013.0036

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, similar images had been obtained before, but the substantially improved image contrast had not been interpreted on the basis of phase effects (e.g. [15]). Owing to its simplicity of implementation, the free-space propagation technique is still widely used, and it is the only one to date to have reached the in vivo stage for human patients [16].…”

Section: X-ray Phase Contrast Imagingsupporting

confidence: 59%

‘Taking X-ray phase contrast imaging into mainstream applications’ and its satellite workshop ‘Real and reciprocal space X-ray imaging’

Olivo

Robinson

2014

Phil. Trans. R. Soc. A.

View full text Add to dashboard Cite

A double event, supported as part of the Royal Society scientific meetings, was organized in February 2013 in London and at Chicheley Hall in Buckinghamshire by Dr A. Olivo and Prof. I. Robinson. The theme that joined the two events was the use of X-ray phase in novel imaging approaches, as opposed to conventional methods based on X-ray attenuation. The event in London, led by Olivo, addressed the main roadblocks that X-ray phase contrast imaging (XPCI) is encountering in terms of commercial translation, for clinical and industrial applications. The main driver behind this is the development of new approaches that enable XPCI, traditionally a synchrotron method, to be performed with conventional laboratory sources, thus opening the way to its deployment in clinics and industrial settings. The satellite meeting at Chicheley Hall, led by Robinson, focused on the new scientific developments that have recently emerged at specialized facilities such as third-generation synchrotrons and free-electron lasers, which enable the direct measurement of the phase shift induced by a sample from intensity measurements, typically in the far field. The two events were therefore highly complementary, in terms of covering both the more applied/translational and the blue-sky aspects of the use of phase in X-ray research. optics, image processing

show abstract

Section: X-ray Phase Contrast Imagingsupporting

confidence: 59%

‘Taking X-ray phase contrast imaging into mainstream applications’ and its satellite workshop ‘Real and reciprocal space X-ray imaging’

Olivo

Robinson

2014

Phil. Trans. R. Soc. A.

View full text Add to dashboard Cite

show abstract

“…Therefore, PBI would not only be suitable for patient lung imaging, but would be extremely beneficial by providing higher resolution images at similar dose levels. However, PBI requires a coherent x-ray source 12 and a detector with a small pixel size to be utilized successfully 14 . Small detector pixels generally come with the disadvantage of requiring more photons and therefore more dose.…”

Section: Discussionmentioning

confidence: 99%

High resolution propagation-based lung imaging at clinically relevant X-ray dose levels

Albers

Wagner

Fiedler

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial tissue. As spatial resolution in CT is limited by the clinically acceptable applied X-ray dose, a comprehensive diagnosis of conditions such as interstitial lung disease, idiopathic pulmonary fibrosis or the characterization of small pulmonary nodules is limited and may require additional validation by invasive lung biopsies. Propagation-based imaging (PBI) is a phase sensitive X-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels. In this publication, we present technical refinements of PBI for the characterization of different artificial lung pathologies, mimicking clinically relevant patterns in ventilated fresh porcine lungs in a human-scale chest phantom. The combination of a very large propagation distance of 10.7 m and a photon counting detector with $$100\,\upmu \hbox {m}$$ 100 μ m pixel size enabled high resolution PBI CT with significantly improved dose efficiency, measured by thermoluminescence detectors. Image quality was directly compared with state-of-the-art clinical CT. PBI with increased propagation distance was found to provide improved image quality at the same or even lower X-ray dose levels than clinical CT. By combining PBI with iodine k-edge subtraction imaging we further demonstrate that, the high quality of the calculated iodine concentration maps might be a potential tool for the analysis of lung perfusion in great detail. Our results indicate PBI to be of great value for accurate diagnosis of lung disease in patients as it allows to depict pathological lesions non-invasively at high resolution in 3D. This will especially benefit patients at high risk of complications from invasive lung biopsies such as in the setting of suspected idiopathic pulmonary fibrosis (IPF).

show abstract

“…This information can be decoupled by applying single-distancephase-retrieval algorithms such as the homogeneous form of Transport of Intensity equation (TIE-Hom) 13 . Thus, an additional requirement of PBI is to utilize detectors with sufficiently small detector elements that allow recording of the aforementioned interference patterns, especially since the parallel x-ray beam configuration does not provide an additional magnification factor 14 . However, there is a trade-off between the pixel size of a detector and its dose efficiency.…”

Section: Introductionmentioning

confidence: 99%

High Resolution Propagation-based Lung Imaging at Clinically Relevant X-Ray Dose Levels

Albers¹,

Wagner

Fiedler

et al. 2022

Preprint

View full text Add to dashboard Cite

Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial tissue. As spatial resolution in CT is limited by the clinically acceptable applied x-ray dose, a comprehensive diagnosis of conditions such as interstitial lung disease, idiopathic pulmonary fibrosis or the characterization of small pulmonary nodules is limited and may require additional validation by invasive lung biopsies. Propagation-based imaging (PBI) is a phase sensitive x-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels. In this publication, we present technical refinements of PBI for the characterization of different artificial lung pathologies, mimicking clinically relevant patterns in ventilated fresh porcine lungs in a human-scale chest phantom. The combination of a very large propagation distance of 10.7 m and a photon counting detector with 100 µm pixel size enabled high resolution PBI CT with significantly improved dose efficiency, measured by thermoluminescence detectors. Image quality was directly compared with state-of-the-art clinical CT. PBI with increased propagation distance was found to provide improved image quality at the same or even lower x-ray dose levels than clinical CT. By combining PBI with iodine k-edge subtraction imaging we further demonstrate that, the high quality of the calculated iodine concentration maps might be a potential tool for the analysis of lung perfusion in great detail. Our results indicate PBI to be of great value for accurate diagnosis of lung disease in patients as it allows to depict pathological lesions non-invasively at high resolution in 3D. This will especially benefit patients at high risk of complications from invasive lung biopsies such as in the setting of suspected idopatic pulmonary fibrosis (IPF).

show abstract

Investigation of the application of phase contrast imaging using a point X-ray source to industrial non-destructive testing

Cited by 3 publications

References 4 publications

‘Taking X-ray phase contrast imaging into mainstream applications’ and its satellite workshop ‘Real and reciprocal space X-ray imaging’

‘Taking X-ray phase contrast imaging into mainstream applications’ and its satellite workshop ‘Real and reciprocal space X-ray imaging’

High resolution propagation-based lung imaging at clinically relevant X-ray dose levels

High Resolution Propagation-based Lung Imaging at Clinically Relevant X-Ray Dose Levels

Contact Info

Product

Resources

About