A tract-based spatial statistics study in anorexia nervosa: Abnormality in the fornix and the cerebellum

Nagahara, Yuri; Nakamae, Takashi; Nishizawa, Susumu; Mizuhara, Yuki; Moritoki, Yukihiro; Wada, Yasaku; Sakai, Yuki; Yamashita, Tatsuhisa; Narumoto, Jin; Miyata, Jun; Yamada, Kazuo; Fukui, Kenji

doi:10.1016/j.pnpbp.2014.01.009

Cited by 46 publications

(66 citation statements)

References 54 publications

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“…FA is related to axon diameter, packing density of fibers, membrane permeability and myelination and is thought to reflect axon integrity (Jones et al, 2013). Four studies have suggested reduced FA in ill anorexia nervosa in the fornix, with evidence of lower FA in fronto-occipital tracts and cerebellum compared with controls (Frank et al, 2013b;Kazlouski et al, 2011;Nagahara et al, 2014;Via et al, 2014). After recovery from anorexia nervosa, small studies (n between 9 and 12 subjects) found differing results with reduced FA in the posterior thalamic radiation (Frieling et al, 2012) or no differences compared with controls (Yau et al, 2013), and clarification is needed.…”

Section: Introductionmentioning

confidence: 99%

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Shott

Pryor

Yang

et al. 2015

Neuropsychopharmacol

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Anorexia nervosa is a severe psychiatric disorder associated with reduced drive to eat. Altered taste-reward circuit white matter fiber organization in anorexia nervosa after recovery could indicate a biological marker that alters the normal motivation to eat. Women recovered from restricting-type anorexia (Recovered AN, n = 24, age = 30.3 ± 8.1 years) and healthy controls (n = 24, age = 27.4 ± 6.3 years) underwent diffusion weighted imaging of the brain. Probabilistic tractography analyses calculated brain white matter connectivity (streamlines) as an estimate of fiber connections in taste-reward-related white matter tracts, and microstructural integrity (fractional anisotropy, FA) was assessed using tract-based spatial statistics. Recovered AN showed significantly (range Po0.05-0.001, Bonferroni corrected) greater white matter connectivity between bilateral insula regions and ventral striatum, left insula and middle orbitofrontal cortex (OFC), and right insula projecting to gyrus rectus and medial OFC. Duration of illness predicted connectivity of tracts projecting from the insula to ventral striatum and OFC. Microstructural integrity was lower in Recovered AN in most insula white matter tracts, as was whole-brain FA in parts of the anterior corona radiata, external capsule, and cerebellum (Po0.05, family-wise errorcorrected). This study indicates higher structural white matter connectivity, an estimate of fibers connections, in anorexia after recovery in tracts that connect taste-reward processing regions. Greater connectivity together with less-fiber integrity could indicate altered neural activity between those regions, which could interfere with normal food-reward circuit function. Correlations between connectivity and illness duration suggest that connectivity could be a marker for illness severity. Whether greater connectivity can predict prognosis of the disorder requires further study.

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Section: Introductionmentioning

confidence: 99%

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Shott

Pryor

Yang

et al. 2015

Neuropsychopharmacol

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“…We attribute the lack of significant associations primarily to the modest sample size and restricted range of individual variability in BMI measures and EDE-Q scores. However, a previous study of comparable size reported significant associations between BMI and FA measured from a region in white matter of the left cerebellum (Nagahara et al, 2014). Interestingly, that study did not observe significant group differences between the AN group and normal weight control group in any cerebral white matter region.…”

Section: Association With Clinical Variablesmentioning

confidence: 65%

Abnormal White Matter Properties in Adolescent Girls With Anorexia Nervosa

Golden

Travis

Feldman

et al. 2016

Journal of Adolescent Health

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“…Analysis of GM and WM in a sample of adolescents in comparison to adults Signa 3T Scanner, axial, 3-dimensional, T-1 weighted magnetization-prepared rapid acquisition gradient echo C-DISC EDI-3 TCI STAI CDI SPSRQ 9 point Likert scale sweetnesspleasantness of 1 molar sucrose Nagahara et al [7] Current AN, NS subtype or Method section. The participant characteristics were clearly described, often being displayed in a chart or table.…”

Section: Anmentioning

confidence: 99%

“…The corpus callosum could be implicated in taste processing Nagahara et al [7] Current AN, NS subtype FA: Lower value in the left cerebellum WM abnormalities in the fornix and the cerebellum may be neural substrates of the pathophysiology of AN. The fornix is one of the important components of the Papez circuit, which links the limbic system with other brain structures.…”

Section: Ref An Subtype Outcomes: Dti Measures and Areas In An Authomentioning

confidence: 99%

“…Severely underweight individuals with AN have altered brain function that is considered more profound than found in any other psychiatric disorder [6] . First computed tomography and then functional magnetic resonance imaging and other neuroimaging techniques have been used to study brain alterations in AN [7] . (FMRI measures the brain activity by detecting associated changes in blood flow, on the premise that cerebral blood flow reflects neuronal activation [8] ).…”

Section: Introductionmentioning

confidence: 99%

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White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

Monzón¹,

Hay²,

Foroughi³

et al. 2016

WJP

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AIM:To identify findings concerning white matter (WM) fibre microstructural alterations in anorexia nervosa (AN). METHODS:A systematic electronic search was undertaken in several databases up to April 2015. The search strategy aimed to locate all studies published in English or Spanish that included participants with AN and which investigated WM using diffusion tensor imaging (DTI). Trials were assessed for quality assessment according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist and a published quality index guideline. RESULTS:A total of 6 studies met the inclusion criteria, four of people in the acute state of the illness, one included both recovered and unwell participants, and one included people who had recovered. Participants were female with ages ranging from 14 to 29 years. All studies but one measured a range of psychopathological features. Fractional anisotropy and mean diffusivity were the main DTI correlates reported. Alterations were reported in a range of WM structures of the limbic SYSTEMATIC REVIEWS Core tip: The present systematic review identifies the latest research on white matter (WM) brain alterations in anorexia nervosa (AN). The WM architecture has been poorly understood due to its structure forming deep parts of the brain. It transmits information between cortical and subcortical structures. New advances in imaging methods with diffusion tensor imaging, allow its characterization and integrity analysis. Alterations in areas of fornix, cingulum, corpus callosum, cerebellum, superior longitudinal fasciculus and thalamus have been found in AN. They could be related to symptoms like anxiety, body image perception, reward processing and cognitive abilities.Martin Monzon B, Hay P, Foroughi N, Touyz S. White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies.

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A tract-based spatial statistics study in anorexia nervosa: Abnormality in the fornix and the cerebellum

Cited by 46 publications

References 54 publications

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Abnormal White Matter Properties in Adolescent Girls With Anorexia Nervosa

White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

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