Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice

Adaramoye, Oluwatosin A.; Tolulope, Akinpelu; Kosoko, Ayokulehin Muse; Patricia, Okorie; Aderemi, Kehinde; Catherine, Falade; Olusegun, Ademowo

doi:10.1016/s1995-7645(14)60003-1

Cited by 55 publications

(31 citation statements)

References 42 publications

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“…It is well established that BW loss is one feature of rodent malaria. The present result is in agreement with other similar studies that reported mice BW loss using different plant extracts and extraction solvents [25][26][27]. The absence of significant PCV reduction among extract treated mice at the doses of 500 and 1,000 mg/kg of the crude leaf extract of B. strychnifolia may indicate the protective activity of this extract.…”

Section: Discussionsupporting

confidence: 93%

Effect of Crude Leaf Extract of Bauhinia strychnifolia in BALB/c Mice Infected with Plasmodium berghei

Chutoam¹,

Klongthalay²,

Somsak³

2015

Malaria Contr Elimination

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Continuous emergence of antimalarial drug resistant malaria parasites and their rapid spread across the globe warrant urgent search for new antimalarials. Traditional medicinal plants have been the main sources for screening active phytochemicals against malaria. Accordingly, this study was aimed at evaluating the antimalarial activity of crude leaf extract of Bauhinia strychnifolia against Plasmodium berghei infected mice. Aqueous crude leaf extract of B. strychnifolia have been prepared and tested for acute toxicity and antimalarial efficacy in P. berghei ANKA infected BALB/c mice. At three oral doses of 100, 500 and 1,000 mg/kg of extract were safe, chemosuppressive and thus prevented body weight loss, packed cell volume reduction and increased mice mean survival time in a dosedependent manner compared to the untreated control group. The maximum efficacious extract was found at the dose of 1,000 mg/kg which prolonged mean mouse survival past day 26 of infection with all the mice in this group having the highest parasitemia suppression rate (85%). This study suggests that the crude leaf extract of this plant have promising antimalarial activity against P. berghei in a dose dependent manner, which supports the folkloric use of the plant for treating malaria.

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Section: Discussionsupporting

confidence: 93%

Effect of Crude Leaf Extract of Bauhinia strychnifolia in BALB/c Mice Infected with Plasmodium berghei

Chutoam¹,

Klongthalay²,

Somsak³

2015

Malaria Contr Elimination

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“…Indeed, G. kola seeds extract can prevent or cure bacterial infection (Stanley et al 2014;Denloye et al 2009). The seed/kernels also contain a chemical called 'kolaviron', a biflavonoide which has antimalarial properties (Murray et al 2012;Oluwatosin et al 2014). Farombi and Owoeye (2011) reported antiviral, antihepatotoxic and antidiabetic properties of G. kola, while anti-sickle cell disease (Antisickling) activities of leaf extracts were revealed by Adejumo et al (2011).…”

Section: Introductionmentioning

confidence: 99%

Propagation of <i>Garcinia kola</i> (Heckel) by stem and root cuttings

Kouakou¹,

Dao²,

Kouassi³

et al. 2016

Silva Fenn.

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(2016). Propagation of Garcinia kola (Heckel) by stem and root cuttings. Silva Fennica vol. 50 no. 4 article id 1588. 17 p. http://dx.doi.org/10.14214/sf.1588. Highlights• Roots and branches cuttings from mature forest trees are difficult to sprout.• The highest mean numbers of roots and buds produced were obtained with softwood cuttings.• The aqueous IBA treatment was more effective than the powder in promoting rooting and root development.• Non-mist poly-propagator gave the best propagation results.• Seedling stockplants cut above node 1 promoted most vigorous shoots production. AbstractThe availability of appropriate propagation techniques is a major constraint to the domestication of the forest trees widely used by rural communities; such as Garcinia kola (Heckel). This study tested the ability of root and stem cuttings to regenerate vegetatively when treated with indole-3-butyric acid (IBA), and set in non-mist poly-propagator within a shaded nursery. It found that G. kola is amenable to propagation by softwood stem cuttings. Attention was given to the effect of cutting age (softwood, semi hardwood) and IBA application with regard to the sprouting and rooting efficiency. Bud and leaf emergence time were also investigated, as was the coppicing ability of the stump. Results revealed that roots and branches from mature forest trees did not sprout under any culture conditions. The highest percentages of rooting (70-85%) were obtained with softwood cuttings set in non-mist poly-propagator, regardless of hormonal treatment. The mean numbers of buds (2.9 ± 0.4) and roots (2.6 ± 0.1) produced by softwood cuttings was significantly greater than those obtained in the Control. The best average emergence time of buds (25.1 days ± 9.3) and leaves (36.8days ± 8.4) was obtained with cuttings treated with IBA and set in non-mist poly-propagator against, 54.4 ± 12.5 and 72.6 ± 3.4 days respectively for the Control. In general, non-mist poly-propagator gave the best propagation results. When coppiced, the shoots emerging from stumps with one node were the most vigorous.

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“…Biflavonoids are flavonoid dimers that have been attached to each other by either C-C or C-O-C bonds representing a variety of chemical structures [2]. Several biological activities such as antioxidant [3,4], antiviral [5], hypolipidemic [6], antidiabetic [7], anti-tumoral [8], antituberculosis [9], antimalarial [10], antibacterial [11], antifungal [12], and anti-inflammatory [13] effects have been reported for biflavonoids.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors

et al. 2014

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Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a well-known therapeutic target for Alzheimer disease (AD) due to its characteristic role in the pathogenesis of AD. Numerous researches have been focused on the design and development of potent peptidic and nonpeptidic BACE-1 inhibitors. In the present contribution, a series of experimentally validated biflavonoid BACE-1 inhibitors (1-21) were subjected to our structure-based molecular modeling studies. Binding modes were elucidated through molecular docking in the active site of the enzyme. Relatively good correlations between the theoretical and experimental binding affinities could be achieved (R 2 = 0.61). Analysis of intermolecular binding energy components was performed via functional B3LYP in association with splitvalence basis set using polarization functions (Def2-SVP), and structure-binding relationships were further elucidated through ligand-residue binding energies. Since little studies have been performed on the modeling and structure activity/binding relationships of biflavonoid structures as BACE-1 inhibitors, the results of this study may be useful in further extending the scope of biflavonoid structures as potential anti-Alzheimer scaffolds.

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Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice

Abstract: This study shows that kolaviron, especially at 200 mg/kg, has high antimalarial activities in P. berghei-infected mice, in addition to its known antioxidant properties.

Cited by 55 publications

References 42 publications

Effect of Crude Leaf Extract of Bauhinia strychnifolia in BALB/c Mice Infected with Plasmodium berghei

Effect of Crude Leaf Extract of Bauhinia strychnifolia in BALB/c Mice Infected with Plasmodium berghei

Propagation of <i>Garcinia kola</i> (Heckel) by stem and root cuttings

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors

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