Emergence of Bluetongue Virus Serotype 1 in French Corsica Island in September 2013

Sailleau, Corinne; Viarouge, Cyril; Bréard, Emmanuel; Perrin, Jean‐Baptiste; Doceul, Virginie; Vitour, Damien; Zientara, Stéphan

doi:10.1111/tbed.12207

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…On day 42, all animals were challenged with BTV1 (4110. 13.06 BTV1 KC2), which was isolated from blood of an infected bovine in 2013 in Corsica (35), followed by passaging in KC cells twice. Several intradermal injections on the inner side of the right thigh were given.…”

Section: Methodsmentioning

confidence: 99%

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Celma

Stewart

Wernike

et al. 2017

J Virol

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Bluetongue virus (BTV) is endemic in many parts of the world, often causing severe hemorrhagic disease in livestock. To date, at least 27 different serotypes have been recognized. Vaccination against all serotypes is necessary to protect susceptible animals and to prevent onward spread of the virus by insect vectors. In our previous studies, we generated replication-deficient (disabled infectious single-cycle [DISC]) virus strains for a number of serotypes and reported preliminary data on their protective efficacy in animals. In this report, to advance the DISC vaccines to the marketplace, we investigated different parameters of these DISC vaccines. First, we demonstrated the genetic stabilities of these vaccine strains and also the complementing cell line. Subsequently, the optimal storage conditions of vaccines, including additives, temperature, and desiccation, were determined and their protective efficacies in animals confirmed. Furthermore, to test if mixtures of different vaccine strains could be tolerated, we tested cocktails of DISC vaccines in combinations of three or six different serotypes in sheep and cattle, the two natural hosts of BTV. Groups of sheep vaccinated with a cocktail of six different vaccines were completely protected from challenge with individual virulent serotypes, both in early challenge and after 5 months of challenge without any clinical disease. There was no interference in protection between the different vaccines. Protection was also achieved in cattle with a mixture of three vaccine strains, albeit at a lesser level than in sheep. Our data support and validate the suitability of these virus strains as the next-generation vaccines for BTV.IMPORTANCE Bluetongue (BT) is a debilitating and in many cases lethal disease that affects ruminants of economic importance. Classical vaccines that afford protection against bluetongue virus, the etiological agent, are not free from secondary and undesirable effects. A surge in new approaches to produce highly attenuated, safer vaccines was evident after the development of the BTV reverse-genetics system that allows the introduction of targeted mutations in the virus genome. We targeted an essential gene to develop disabled virus strains as vaccine candidates. The results presented in this report further substantiate our previous evidence and support the suitability of these virus strains as the next-generation BTV vaccines.

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Section: Methodsmentioning

confidence: 99%

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Celma

Stewart

Wernike

et al. 2017

J Virol

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“…More recently, in Corsica with the outbreak of BTV‐1 in 2013, morbidity and mortality rates on the day of notification varied from 1% to 80% and 0% to 11%, respectively, depending on the herds. (Sailleau et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

More¹,

Bicout²,

Bøtner³

et al. 2017

EFS2

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A specific concept of strain was developed in order to classify the BTV serotypes ever reported in Europe based on their properties of animal health impact: the genotype, morbidity, mortality, speed of spread, period and geographical area of occurrence were considered as classification parameters. According to this methodology the strain groups identified were (i) the BTV strains belonging to serotypes BTV-1-24, (ii) some strains of serotypes BTV-16 and (iii) small ruminant-adapted strains belonging to serotypes BTV-25, -27, -30. Those strain groups were assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7, Article 5 on the eligibility of bluetongue to be listed, Article 9 for the categorisation according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to bluetongue. The assessment has been performed following a methodology composed of information collection, expert judgement at individual and collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. The strain group BTV (1-24) can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL, while the strain group BTV-25-30 and BTV-16 cannot. The strain group BTV-1-24 meets the criteria as in Sections 2 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (b) and (e) of Article 9(1) of the AHL. The animal species that can be considered to be listed for BTV-1-24 according to Article 8(3) are several species of Bovidae, Cervidae and Camelidae as susceptible species; domestic cattle, sheep and red deer as reservoir hosts, midges insect of genus Culicoides spp. as vector species.

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“…This introduction could have occurred either by wind‐borne movements of adult Culicoides midges (12 km between the two islands) or by the introduction of an infected animal. The same events occurred few years ago with the incursion of BTV‐2, 4, 16 and 1 (Breard et al., ; Gerbier et al., ; Sailleau et al., ; Zientara et al., ). Since the report of BTV‐4 in this herd, no other outbreak has been reported in the island.…”

Section: Resultsmentioning

confidence: 87%

“…A total of 39 outbreaks caused by BTV-4, and 16 were then recorded on the island with a predominance of BTV-16 (Zientara, MacLachlan, Calistri, Sanchez-Vizcaino, & Savini, 2010). In 2013, a new serotype (BTV-1) was detected in the south of Corsica (Sailleau et al, 2015). The location of the first outbreaks and the molecular data strongly suggested that the virus has been introduced to Corsica from the island of Sardinia, where many outbreaks of BTV-1 have been reported during autumn 2012 (Lorusso et al, 2013) and summer 2013.…”

Section: Introductionmentioning

confidence: 99%

Complete genome sequence of bluetongue virus serotype 4 that emerged on the French island of Corsica in December 2016

Sailleau

Bréard

Viarouge

et al. 2017

Transbound Emerg Dis

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Summary In November 2016, sheep located in the south of Corsica island exhibited clinical signs suggestive of bluetongue virus (BTV) infection. Laboratory analyses allowed to isolate and identify a BTV strain of serotype 4. The analysis of the full viral genome showed that all the 10 genomic segments were closely related to those of the BTV‐4 present in Hungary in 2014 and involved in a large BT outbreak in the Balkan Peninsula. These results together with epidemiological data suggest that BTV‐4 has been introduced to Corsica from Italy (Sardinia) where BTV‐4 outbreaks have been reported in autumn 2016. This is the first report of the introduction in Corsica of a BTV strain previously spreading in eastern Europe.

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Emergence of Bluetongue Virus Serotype 1 in French Corsica Island in September 2013

Cited by 12 publications

References 10 publications

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

Complete genome sequence of bluetongue virus serotype 4 that emerged on the French island of Corsica in December 2016

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