Primary subcutaneous mixed-type liposarcoma of the thigh showing three simultaneous dedifferentiations: Report of an unusual case

Patne, Shashikant C. U.; Kumar, Mohan; Vishwanath, A. K.; Pandey, Manoj

doi:10.4103/0377-4929.125358

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Superficial liposarcomas are uncommon. A comprehensive review of the literature revealed 159 cases in the dermis and/or subcutis, with only 44 cases mentioning dermal involvement . Superficial liposarcomas have been reported in all four liposarcoma subtypes with PLPS being the most common (n = 95) .…”

Section: Discussionmentioning

confidence: 99%

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

et al. 2020

View full text Add to dashboard Cite

Liposarcomas are categorized into four distinct histopathological subtypes: atypical lipomatous tumors (ALT)/well-differentiated liposarcoma (WDL), dedifferentiated, myxoid, and pleomorphic. Dedifferentiated liposarcomas account for approximately 18% of all liposarcomas, characteristically arising in the deep soft tissue. They are reported to have lower rates of metastasis compared to other pleomorphic sarcomas. 1-3 The classic histopathologic appearance is ALT/WDL admixed or juxtaposed with a predominantly nonlipogenic sarcoma. Epithelioid features are rare, appearing in as few as 3% of tumors, and have not previously been reported in a superficial location. Herein, we present a 57-year-old male with intradermal and subcutaneous metastasis of his known deep dedifferentiated liposarcoma with epithelioid features.By H&E the tumor featured cords and sheets of crowded, plump, epithelioid cells with thick nuclear membranes and prominent nucleoli, which raised a broad differential including carcinoma and melanoma. By immunohistochemistry the tumor was diffusely positive for MDM2 and CDK4, on the other hand stains for Sox10, Melan A, MITF, CKAE1/3, desmin, and S100 protein were negative. This case serves as an opportunity to raise awareness of this rare morphological subtype, which can involve the skin and mimic epithelial and melanocytic malignancies. It can be a potential diagnostic pitfall, especially if metastases are the first presentation. K E Y W O R D S cutaneous, dedifferentiated, epithelioid, liposarcoma, MDM2, metastasis

show abstract

Section: Discussionmentioning

confidence: 99%

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

et al. 2020

View full text Add to dashboard Cite

show abstract

A Rare Case of Dedifferentiated Liposarcoma With C Hondrosarcomatous Dedifferentiation

Agrawal¹,

Garg²,

Kaur³

et al. 2015

jemds

View full text Add to dashboard Cite

We report a rare case of dedifferentiated liposarcoma with chondrosarcomatous components. A 39 years old male presenting with a left buttock swelling underwent a wide tumor excision. The histopathological diagnosis was dedifferentiated liposarcoma (DDLS) with chondrosarcomatous dedifferentiation. Histologically, DDLS is represented by the abrupt transition from well differentiated liposarcoma to a region of non-lipogenic sarcoma. Dedifferentiation frequently resembles a malignant fibrous histiocytoma-like pleomorphic sarcoma. Divergent differentiation with chondrosarcomatous components is very rare. We present here a case of gluteal dedifferentiated liposarcoma with chondrosarcomatous dedifferentiation because of its extreme rarity.

show abstract

Primary subcutaneous mixed-type liposarcoma of the thigh showing three simultaneous dedifferentiations: Report of an unusual case

Cited by 2 publications

References 0 publications

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

A Rare Case of Dedifferentiated Liposarcoma With C Hondrosarcomatous Dedifferentiation

Contact Info

Product

Resources

About