Effectiveness, safety and acceptability of Sino-implant (II) during the first year of use: results from Kenya and Pakistan

Abstract

The favorable Sino-implant (II) findings from Kenya and Pakistan provide further evidence from disparate regions that Sino-implant (II) is safe, effective and acceptable during routine service delivery.

Twelve month follow‐up of a contraceptive implant outreach service in rural Papua New Guinea

“…However, we can be reasonably confident that this was not a significant contributing factor because the majority of women were very happy with the device and indicated that they would use it again. Irregular bleeding was the most commonly reported side effect among our participants, which is consistent with self‐reporting in other countries, but this alone was not a major motivator for device removal. Irregular bleeding appears to be a larger contributor to implant removal in other low resource settings, resulting in up to 35% of removals within 12 months in Kenyan and Pakistani cohorts …”

“…Most outreach projects utilise the Jadelle or Sino 2 implant: a subcutaneous two rod contraceptive implant containing a total of 150 mg levonorgestrel which provides reliable and effective contraception for up to five years . Twelve month follow‐up data for the Sino 2 Implant in similar low‐resource settings in Kenya, Pakistan and Madagascar demonstrated low pregnancy probabilities (0–0.1%), low discontinuation rates (< 10%) and high user satisfaction (> 80%) scores …”

Availability and Use of Contraceptive Implants in Jamaica: Results of a Medical Record Review and Provider Survey in Six Health Centers

“…Changes in menstrual patterns were common and were the primary reason for premature implant discontinuation, consistent with previous studies (13,15). The observed frequency of implant discontinuation for Jadelle and Sino-Implant (II) users in Jamaica was lower than those previously reported in other settings (12,15).…”

“…Our medical record review is the first survey of contraceptive implant utilization patterns in Jamaica. Sino-Implant (II), approved for use by the People's Republic of China in 1996, is a slightly less expensive levonorgestrel implant than Jadelle with a comparable safety and efficacy profile (12,13). Sino-Implant (II) studies from the USA, Kenya and Pakistan have reported first-year discontinuation rates of 7% (12).…”

“…Sino-Implant (II), approved for use by the People's Republic of China in 1996, is a slightly less expensive levonorgestrel implant than Jadelle with a comparable safety and efficacy profile (12,13). Sino-Implant (II) studies from the USA, Kenya and Pakistan have reported first-year discontinuation rates of 7% (12). A systematic review of Sino-Implant (II) studies reported first-year pregnancy rates of 0.0-0.1% and that menstrual disorders were the primary side-effect and reason for discontinuation (13).…”