Lack of Association of the P450 Oxidoreductase *28 Single Nucleotide Polymorphism with the Lipid-Lowering Effect of Statins in Hypercholesterolemic Patients

Abstract

The POR*28 allele was not associated with the lipid-lowering effect of atorvastatin and the results were replicated in an independent simvastatin-treated population. The hypothesized effect of the POR*28 allele on the lipid-lowering response to CYP3A-metabolized statins can potentially be masked by relevant confounding or uncontrolled factors; therefore, further studies in different populations are required.

Effects of Major Transporter and Metabolizing Enzyme Gene Polymorphisms on Carbamazepine Metabolism in Chinese Patients with Epilepsy

“…POR transfers electrons from NADPH to CYP3A enzymes to enable their catalytic activity [21,22]. The human POR gene is highly polymorphic.…”

Effect of NADPH–cytochrome P450 reductase on all-trans-retinoic acid efficacy and cytochrome P450 26A1 expression in human myeloid leukaemia HL-60 cells

“…With the total length of 72 kb, the POR gene is highly polymorphic . The genetic polymorphisms of POR could affect the efficacy of the drugs such as tirapazamine, mitomycin C, cyclophosphamide, midazolam, warfarin, tacrolimus, atorvastatin, clobazam and nifedipine directly or mediated by CYP enzymes . In addition, our study has found that POR rs2868177 could significantly increase CYP2B6 activity as measured by bupropion hydroxylation (data not published).…”

Novel insights on the treatment of hypercholesterolemia

“…Children with familial hypercholesterolemia (FH) carriers of POR*28 allele seem to be associated with reduced effect of atorvastatin on total cholesterol and LDL-C, so this allele identifies subjects that may require higher atorvastatin doses to achieve full therapeutic benefits [5]. Nevertheless, published data are discordant and considering the current stateof-the-art further studies involving wider and different populations are required [6].…”