Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers

Thomas, Jason; Dourish, C T; Tomlinson, Jeremy W.; Hassan‐Smith, Zaki; Higgs, Suzanne

doi:10.1007/s00213-013-3409-x

Cited by 23 publications

(43 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context it may be worth considering that translational medicine of disease/obesity between phase 1 and phase 2 of clinical trials could provide early inside in efficacy and safety in humans [349]. Such a translational approach using the 5-HT2C/1B agonist mCPP has recently been exemplified in humans [350].…”

Section: Serotonin and The Pharmacotherapy Of Obesitymentioning

confidence: 99%

“…Combining the 5-HT2C/1B agonist mCPP with the CB1 antagonist/partial agonist rimonabant synergistically reduced motivated feeding behaviour in an operant paradigm in mice [360]. Testing mCPP in humans provides clear evidence that this 5-HT2C/1B agonist not only promotes satiation and satiety, but also suppresses appetite [350].…”

Section: Serotonin and The Pharmacotherapy Of Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Serotonin controlling feeding and satiety

Voigt

Fink

2015

Behavioural Brain Research

242

156

View full text Add to dashboard Cite

Serotonin has been implicated in the control of satiety for almost four decades. Historically, the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has stimulated interest in and research into the role of this neurotransmitter in satiety. Various rodent models, including transgenic models, have been developed to identify the involved 5-HT receptor subtypes. This approach also required the availability of receptor ligands of different selectivity, and behavioural techniques had to be developed simultaneously which allow differentiating between unspecific pharmacological effects of these ligands and 'true' 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3 IntroductionWhat are the behavioural and physiological mechanisms that promote satiety? How is satiety defined? Satiety can be seen as a behavioural state which arises from food consumption and suppresses the initiation of eating for a particular period of time [1]. This description alone suggests a high degree of complexity as peripheral post-ingestive and post-absorptive signals need to be relayed to the brain where they are integrated with other signals to produce (or not) the behavioural state called satiety. The state of satiety is brought about a process called satiation, where sensory, cognitive and early post-ingestive mechanisms bring feeding to a halt and thus stopping a meal. Promoting satiation alone must not necessarily lead to reduced total food intake as the frequency of meals could be increased subsequently. Many peripheral and brain mechanisms have been identified that are involved in the expression satiety and it has been suggested that serotonin accelerates satiation and prolongs satiety [2]. In the following, we will review the role of serotonin in satiety in more detail 1 . The reader will see that, despite immense progress made during the last years, the field is still far from being resolved.As serotonin (5-Hydroxytryptamine; 5-HT) is a phylogenetically old neurotransmitter, various functions had time to evolve in different phyla, but maybe also in different species. 5-HT receptors exist in animal cells for millions of years and they are as old as adrenoreceptors ore some peptide receptors, possibly even older [5,6]. Even in invertebrates such as molluscs (Aplysia californica) and annelids (Hirudo medicinalis), 5-HT might functionally be related to food intake [7]. 5-HT is involved in feeding even in the honeybee where it has separate effects in the gut and in the insect brain [8]. In general, however, 5-HT seems rather to be involved in appetitive behaviours in invertebrates whereas it has more of a satiating effect in vertebrates [9]. In general, 5-HT neurons seem to be more extensively distributed throughout the body in lower animals than in higher animals including mammals where 5-HT neurones...

show abstract

Section: Serotonin and The Pharmacotherapy Of Obesitymentioning

confidence: 99%

Section: Serotonin and The Pharmacotherapy Of Obesitymentioning

confidence: 99%

Serotonin controlling feeding and satiety

Voigt

Fink

2015

Behavioural Brain Research

242

156

View full text Add to dashboard Cite

show abstract

“…Participants' appetite ratings before and after ice cream consumption as well as palatability and the sensory attributes of the different ice creams were evaluated using on-screen visual analogue scales (VAS). The use of mixed paper and pen and computerised VAS has been validated elsewhere (Thomas et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Coconut and sunflower oil ratios in ice cream influence subsequent food selection and intake

Rizzo

Masic

Harrold

et al. 2016

Physiology & Behavior

View full text Add to dashboard Cite

The effect of coconut oil (CO, containing mainly medium chain triglycerides - MCTs) and sunflower oil (SO, containing mainly long chain triglycerides - LCTs) used as fat source (10% fat ice cream) in different ratios (25% CO and 75% SO - 25CO:75SO, 50% CO and 50% SO - 50CO:50SO, 75% CO and 25% SO - 75CO:25SO) was investigated to assess differences in appetite and ad-libitum (evening and snack) food intake using a single blind design. 36 healthy female participants consumed a fixed portion (150g) of ice cream 45min before an ad-libitum dinner and snacks. Appetite sensations were tracked across the day. Participants ate significantly less fat after 75CO:25SO than 25CO:75SO (p=0.007) and there was also a trend for lower fat intake in this condition as compared to 50CO:50SO (p=0.068). High fat savoury snack intake significantly decreased after 75CO:25SO in comparison with both 25CO:75SO (p=0.038) and 50CO:50SO (p=0.008). Calorie intake from snacks was also found to be significantly lower after 25CO:75SO and 50CO:50SO than 75CO:25SO (p=0.021 and 0.030 respectively). There was no effect of condition on appetite or desire ratings over the day. Eating a standard portion of ice cream containing different ratios of MCTs and LCTs can modestly influence acute food selection and intake, with MCTs manifesting their effect earlier and LCTs later due to differences in the absorption and metabolism of these lipids. However, the differences evident in the present study were small, and require further research before firm conclusions can be drawn.

show abstract

“…Moreover, desensitization of the 5-HT2CR in SERT KO mice reduces the anxiety phenotype (Martin et al 2015) and show antidepressant-like effects (Prisco and Esposito, 1995;Di Giovanni et al 2006). The situation is however more complex: although, mCPP induces anxiety in mice (Kennett et al 1989;Nic Dhonnchadha et al 2003), it has antidepressant-like properties in the anhedonia model in rats (Moreau et al 1996) and is apparently anorexigenic without inducing anxiety/depression in humans (Thomas et al 2014). RO60-0175, a 5-HT2CR agonist, shows antidepressant and anxiolytic/anti-compulsive like effects in some rodent models Nic Dhonnchadha et al 2003).…”

Section: Depression and Anxiety: Agomelatine And Othersmentioning

confidence: 99%