Bone Metastases, Skeletal-related Events, and Survival Among Children With Cancer in Denmark

Hernandez, Rohini K.; Mægbæk, Merete Lund; Liede, Alexander; Sørensen, Henrik Toft; Ehrenstein, Véra

doi:10.1097/mph.0000000000000106

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…Bone Scintigraphy is a famous method for imaging wide variations of benign or malignant skeletal abnormalities Although bone metastasis is uncommon among children with cancer [3], the main cause of referral was metastatic work up. This is attributed to the fact that skeletal-related events affects the disease future [3].…”

Section: Discussionmentioning

confidence: 99%

Young Population Attending for Whole Body Technetium 99MDP Bone Scintigraphy: A Single Institution Experience

Halim

Hamed³

2018

Journal of Bone Biology and Osteoporosis

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Objective: Radionuclide isotope scanning is a sensitive scanning procedure for the detecting of bone pathology. This article focuses on an institution experience bone Scintigraphy applications in patients below 25 years.Patients and methods: This study is a retrospective descriptive study that analyzed the handwritten medical records of patients younger than 25 years old referred for Technetium bone scan in Mansoura University Hospital, Nuclear Medicine Unit from August 2011 to October 2015.Results: Seventy-six patients younger than 25 years old were referred for bone scan. The main cause of referral was metastatic work up. Osteosarcomas and Ewing tumors constituted together the commonest malignant tumors referred while osteochondromas were the commonest benign tumors. The area around the knee was the commonest affected area in the primary bone neoplasm’s while the vertebrae and the pelvis were the commonest sites of distant metastasis. No recorded complications existed secondary to the injection of the radioactive material. The commonest defect was lack of documentation of the family history.Conclusion: This study helped to elucidate the extent of medical support that our nuclear medicine unit can give to other pediatric and adolescent medical specialties. It demonstrates also the wise selection of the cases to be referred for bone scan. To maximize the benefit from our bone scan service, analysis of differences between our unit and older larger units in the country is needed as regard policy decisions and financing. Digital reporting will put an end to mistakes in handwritten patient records.

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Section: Discussionmentioning

confidence: 99%

Young Population Attending for Whole Body Technetium 99MDP Bone Scintigraphy: A Single Institution Experience

Halim

Hamed³

2018

Journal of Bone Biology and Osteoporosis

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“…Recent studies revealed its elevated expression in various malignant tumors, including breast cancer and prostate cancer, and its correlation with patients’ prognosis, thereby suggesting its potential relationship with the invasion ability of the tumor [ 10 , 11 ]. DNA-microarray analysis found elevated expression of PMP22 in osteosarcoma tissues especially in those with high prevalence of metastasis [ 26 ]. These results suggest the potential oncogene role of PMP22 in the occurrence of osteosarcoma, but leaving its detailed mechanisms unresolved.…”

Section: Discussionmentioning

confidence: 99%

The Functional Role of PMP22 Gene in the Proliferation and Invasion of Osteosarcoma

Liu

Chen

2015

Med Sci Monit

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BackgroundAs the most common primary bone tumor, osteosarcoma has an improved survival rates with advancement of treatment methods. A higher rate of metastasis, however, leads to the aggravation of the disease. Studies have shown that some genes, namely osteosarcoma metastasis-related genes, participate in the process of tumor metastasis. The peripheral myelin protein 22 (PMP22) gene has recently been found to be abundantly expressed in the oncogenesis of osteosarcoma. Its detailed role and function in the tumor metastasis, however, remains unknown.Material/MethodsThe recombinant retroviral plasmid pcDNA3.1-PMP22 was constructed and used to transfect osteosarcoma cells SOSP-M, whose cell proliferation was measured by MTT method. The formation of tumor cell colony, the cell migration and invasion were also measured. The signal transduction pathway MAPK was further analyzed by Western blotting.ResultsThe pcDNA3.1-PMP22 plasmid was confirmed to have a 305bp PMP22 fragment by EcoRI-XhoI dual digestion. Compared to the control group, osteosarcoma cell invasion was significantly facilitated by the transfection of pcDNA3.1-PMP22 plasmid (p<0.05). The recombinant plasmid also significantly potentiated the formation of tumor cell colony and increased the migration and invasion ability of tumor cells (p<0.05 in all cases). Phosphorylated p-ERK and p-P38 were also up-regulated by vector transfection (p<0.05).ConclusionsOsteosarcoma metastasis-related gene PMP22 participates in the proliferation, invasion, migration and colony formation of osteosarcoma cells possibly via the MAPK signal transduction pathway, providing evidences for further investigation of metastatic mechanism of osteosarcoma.

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“…Bone metastases can occur in advanced neuroblastoma, osteosarcoma, or childhood sarcomas (such as Ewing sarcoma or rhabdomyosarcoma). 15 These sites cause somatic pain, though patients with extraosseous extension may experience paresthesias or neuropathic pain. Pain from bone metastases is a widely accepted indication for palliative RT.…”

Section: Bone Metastasesmentioning

confidence: 99%

Palliative radiation therapy for children with cancer

Tsang

Vargo

Goddard

et al. 2021

Pediatric Blood & Cancer

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Radiation therapy (RT) is often used as a palliative treatment for children with recurrent malignant disease to ameliorate or prevent symptoms. However, no guidelines exist regarding the clinical indications or dose fractionation for palliative RT. The goal of this report is to provide guidelines for the use of palliative RT in children with cancer. In this guideline, appropriate indications for palliative RT, recommended dose‐fractionation schedules, relevant toxicities, and avenues for future research are explored. RT is an effective palliative treatment for bone, brain, liver, lung, abdominopelvic and head‐and‐neck metastases, spinal cord compression, superior vena cava syndrome, and bleeding. Single‐fraction regimens (8 Gy in one fraction) for children with short life expectancy are recommended for simple, uncomplicated bone metastases and can be considered for some patients with lung or liver metastases. A short, hypofractionated regimen (20 Gy in five fractions) may be used for other indications to minimize overall burden of therapy. There are little data supporting use of more prolonged fractionation regimens, though they may be considered for patients with very good performance status. Future research should focus on response and outcomes data collection, and to rigorously evaluate the role of stereotactic body RT in well‐designed, prospective studies.

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Bone Metastases, Skeletal-related Events, and Survival Among Children With Cancer in Denmark

Cited by 10 publications

References 15 publications

Young Population Attending for Whole Body Technetium 99MDP Bone Scintigraphy: A Single Institution Experience

Young Population Attending for Whole Body Technetium 99MDP Bone Scintigraphy: A Single Institution Experience

The Functional Role of PMP22 Gene in the Proliferation and Invasion of Osteosarcoma

Palliative radiation therapy for children with cancer

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