Evaluación de la invasión extracapsular y otros parámetros de estadificación mediante resonancia nuclear magnética multiparamétrica en pacientes con cáncer de próstata candidatos a prostatectomía radical

Lista, F.; Gimbernat, H.; Cáceres, F.; Rodríguez-Barbero, J.M.; Castillo, Ernesto; Angulo, Javier C.

doi:10.1016/j.acuro.2013.11.003

Cited by 33 publications

(7 citation statements)

References 24 publications

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“…Other studies have evidenced that a high percentage of patients have GS ≥7 at non-index tumors and mp-MRI has low power for the detection of these lesions ( 23 ). Also, the diffusion coefficient ADC allows for quantitative and qualitative assessment of tumor aggressiveness and has positive correlation with GS ( 24 ). In this study, ADC as binary variable when compared to GS >=8 had high specificity and NPV, low AUC and its values are inversely correspondent to GS as reported with Spearman rho, although it shows a low negative correlation.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of multiparametric magnetic resonance imaging in detecting extracapsular extension in intermediate and high - risk prostate cancer

et al. 2018

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Objectives:To evaluate the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) as a predictor of extracapsular extension (ECE) and unfavorable Gleason score (GS) in patients with intermediate and high-risk prostate cancer (PCa).Materials and Methods:Patients with clinically localized PCa who underwent radical prostatectomy (RP) and had preoperative mp-MRI between May-2011 and December-2013. Mp-MRI was evaluated according to the European Society of Urogenital Radiology MRI prostate guidelines by two different readers. Histopathological RP results were the standard reference.Results:79 patients were included; mean age was 61 and median preoperative prostate-specific antigen (PSA) 7.0. On MRI, 28% patients had ECE evidenced in the mp-MRI, 5% seminal vesicle invasion (SVI) and 4% lymph node involvement (LNI). At RP, 39.2% had ECE, 26.6% SVI and 12.8% LNI. Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of mp-MRI for ECE were 54.9%, 90.9%, 76%, 81% and 74.1% respectively; for SVI values were 19.1%, 100%, 77.3%, 100% and 76.1% respectively and for LNI 20%, 98.4%, 86.7%, 66.7% and 88.7%.Conclusions:Major surgical decisions are made with digital rectal exam (DRE) and ultrasound studies before the use of Mp-MRI. This imaging study contributes to rule out gross extraprostatic extension (ECE, SVI, LNI) without competing with pathological studies. The specificity and NPV are reasonable to decide surgical approach. A highly experienced radiology team is needed to provide accurate estimations of tumor extension and aggressiveness.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of multiparametric magnetic resonance imaging in detecting extracapsular extension in intermediate and high - risk prostate cancer

et al. 2018

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“…115 A regression model for predicting ECE showed that the most reliable predictors are DW-MRI + DCE-MRI and Gleason score. 116 …”

Section: Value Of Mpmri In Clinical Decision-makingmentioning

confidence: 99%

DCE-MRI, DW-MRI, and MRS in Cancer

Winfield

Payne

Weller

et al. 2016

Topics in Magnetic Resonance Imaging

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Multi-parametric magnetic resonance imaging (mpMRI) offers a unique insight into tumor biology by combining functional MRI techniques that inform on cellularity (diffusion-weighted MRI), vascular properties (dynamic contrast-enhanced MRI), and metabolites (magnetic resonance spectroscopy) and has scope to provide valuable information for prognostication and response assessment. Challenges in the application of mpMRI in the clinic include the technical considerations in acquiring good quality functional MRI data, development of robust techniques for analysis, and clinical interpretation of the results. This article summarizes the technical challenges in acquisition and analysis of multi-parametric MRI data before reviewing the key applications of multi-parametric MRI in clinical research and practice.

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“…MP-MRI is able to identify areas of seminal vesicle invasion (SVI) (that can potentially undergo subsequent targeted biopsy for tissue confirmation), extracapsular extension (ECE), and even pelvic lymph node involvement. Recent series have reported sensitivity of >80% and specificity of >90 [23–25]. Soylu et al reviewed 131 patients who underwent radical prostatectomy with preoperative MRI finding a 17.6% rate of seminal vesicle invasion on final pathology.…”

Section: Integration Of Mp-mrimentioning

confidence: 99%

Multiparametric MRI in the PSA Screening Era

George

Pinto

Rais‐Bahrami

2014

BioMed Research International

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Prostate cancer remains significant public health concern amid growing controversies regarding prostate specific antigen (PSA) based screening. The utility of PSA has been brought into question, and alternative measures are investigated to remedy the overdetection of indolent disease and safeguard patients from the potential harms resulting from an elevated PSA. Multiparametric MRI of the prostate has shown promise in identifying patients at risk for clinically significant disease but its role within the current diagnostic and treatment paradigm remains in question. The current review focuses on recent applications of MRI in this pathway.

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Evaluación de la invasión extracapsular y otros parámetros de estadificación mediante resonancia nuclear magnética multiparamétrica en pacientes con cáncer de próstata candidatos a prostatectomía radical

Cited by 33 publications

References 24 publications

Diagnostic accuracy of multiparametric magnetic resonance imaging in detecting extracapsular extension in intermediate and high - risk prostate cancer

Diagnostic accuracy of multiparametric magnetic resonance imaging in detecting extracapsular extension in intermediate and high - risk prostate cancer

DCE-MRI, DW-MRI, and MRS in Cancer

Multiparametric MRI in the PSA Screening Era

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