BIRB 796 has Distinctive Anti-inflammatory Effects on Different Cell Types

Ryoo, Soyoon; Choi, Jida; Kim, Jaemyung; Bae, Sang Rak; Hong, Jaewoo; Jo, Seunghyun; Kim, Soohyun; Lee, Young-Min

doi:10.4110/in.2013.13.6.283

Cited by 21 publications

(13 citation statements)

References 23 publications

(23 reference statements)

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“…RAW264.7 macrophage cells (1 Â 10 6 cells/ml) were cultured for 18 h, pretreated with Pa-ME (0 to 300 μg/ml) for 30 min, and further incubated with LPS (1 μg/ml) for 24 h. The effect of Pa-ME on NO and PGE 2 production was determined by the Griess assay and enzyme immunoassays (EIAs), respectively, as previously described (Green et al, 1982;Ryoo et al, 2013).…”

Section: No and Pge 2 Productionmentioning

confidence: 99%

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

Hossen

Jeon

Kim

et al. 2015

Journal of Ethnopharmacology

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Section: No and Pge 2 Productionmentioning

confidence: 99%

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

Hossen

Jeon

Kim

et al. 2015

Journal of Ethnopharmacology

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“…BIRB-796 enhances cytotoxicity and inhibits paracrine tumor growth in multiple myeloma [ 59 ], enhances the efficacy of chemotherapeutic agents in multidrug resistance protein 1 (ABCB1) overexpressing oral epidermoid carcinoma cells [ 60 ], and enhances the antitumor effects of aurora kinase inhibitor VX680 in cervical cancer [ 61 ]. It is also used in inflammation research [ 62 , 63 ].…”

Section: Map Kinase Inhibitors In Cancer Researchmentioning

confidence: 99%

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

Cicenas

Žalytė

Rimkus

et al. 2017

Cancers

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Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a range of biological processes implicated in the response to growth factors like latelet-derived growth factor (PDGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and stress, such as ultraviolet irradiation, heat shock, and osmotic shock. The MAP kinase family consists of four major subfamilies of related proteins (extracellular regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), p38, and extracellular regulated kinase 5 (ERK5)) and regulates numerous cellular activities, such as apoptosis, gene expression, mitosis, differentiation, and immune responses. The deregulation of these kinases is shown to be involved in human diseases, such as cancer, immune diseases, inflammation, and neurodegenerative disorders. The awareness of the therapeutic potential of the inhibition of MAP kinases led to a thorough search for small-molecule inhibitors. Here, we discuss some of the most well-known MAP kinase inhibitors and their use in cancer research.

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“…In addition, this plant has been demonstrated to exhibit antidiabetic, anticancer, antiobesity, antilipogenic, and hepatoprotective activities [15–18]. Lancemaside A (Figure 1) is a representative triterpenoid saponin that highlights the pharmacological activities of Codonopsis lanceolata [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Lancemaside A fromCodonopsis lanceolataModulates the Inflammatory Responses Mediated by Monocytes and Macrophages

Kim

Yang

Kim

et al. 2014

Mediators of Inflammation

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In this study, we aimed to examine the cellular and molecular mechanisms of lancemaside A from Codonopsis lanceolata (Campanulaceae) in the inflammatory responses of monocytes (U937 cells) and macrophages (RAW264.7 cells). Lancemaside A significantly suppressed the inflammatory functions of lipopolysaccharide- (LPS-) treated RAW264.7 cells by suppressing the production of nitric oxide (NO), the expression of the NO-producing enzyme inducible NO synthase (iNOS), the upregulation of the costimulatory molecule CD80, and the morphological changes induced by LPS exposure. In addition, lancemaside A diminished the phagocytic activity of RAW264.7 cells and boosted the neutralizing capacity of these cells when treated with the radical generator sodium nitroprusside (SNP). Interestingly, lancemaside A strongly blocked the adhesion activity of RAW264.7 cells to plastic culture plates, inhibited the cell-cell and cell-fibronectin (FN) adhesion of U937 cells that was triggered by treatment with an anti-β1-integrin (CD29) antibody and immobilized FN, respectively. By evaluating the activation of various intracellular signaling pathways and the levels of related nuclear transcription factors, lancemaside A was found to block the activation of inhibitor of κB kinase (IKK) and p65/nuclear factor- (NF-) κB. Taken together, our findings strongly suggest that the anti-inflammatory function of lancemaside A is the result of its strong antioxidative and IKK/NF-κB inhibitory activities.

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BIRB 796 has Distinctive Anti-inflammatory Effects on Different Cell Types

Cited by 21 publications

References 23 publications

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

Lancemaside A fromCodonopsis lanceolataModulates the Inflammatory Responses Mediated by Monocytes and Macrophages

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