Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review

Kumar, Naresh; Chen, Yongsheng; Zaw, Aye Sandar; Nayak, D.; Ahmed, Qasim; Soong, Richie; Wong, Hee Kit

doi:10.1016/s1470-2045(13)70245-6

Cited by 70 publications

(46 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the above fact, evidence has accumulated supporting the use of IOCS in different surgical disciplines, i.e. gynaecological, hepatobiliary, gastrointestinal, urological and lung cancer surgery [12][13][14][15][16][17][18][19][20][21]. Other studies provided evidence that if leucocyte depletion filter (LDF) is added, the combination could eliminate all tumour cells from salvaged blood, rendering it safe [3,9,22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, there remain many controversies among the orthopaedic and spine surgeons worldwide on the use of IOCS in 'metastatic spine tumour surgery'' (MSTS). There has been no evidence in the literature supporting the use of IOCS in MSTS [18]. We hereby conducted a large non-reinfusion study to evaluate the safety of IOCS-LDF processed blood in MSTS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…In oncology patients, cell saving might be indicated after radiation or filtration of washed blood, using leukocyte depletion filters or in cases of massive bleeding [81]. In addition, a focus on the number of swabs used for blood absorption and the reuse of washed swabs combined with autologous cell salvage allows reduction of irreversible blood loss.…”

Section: Reduction Of Surgery-related Blood Loss (Subgroup Of Surgicamentioning

confidence: 99%

Patient Blood Management Bundles to Facilitate Implementation

Meybohm

Richards

Isbister

et al. 2017

Transfusion Medicine Reviews

181

117

View full text Add to dashboard Cite

More than 30% of the world's population are anemic with serious economic consequences including reduced work capacity and other obstacles to national welfare and development. Red blood cell transfusion is the mainstay to correct anemia, but it is also 1 of the top 5 overused procedures. Patient blood management (PBM) is a proactive, patient-centered, and multidisciplinary approach to manage anemia, optimize hemostasis, minimize iatrogenic blood loss, and harness tolerance to anemia. Although the World Health Organization has endorsed PBM in 2010, many hospitals still seek guidance with the implementation of PBM in clinical routine. Given the use of proven change management principles, we propose simple, cost-effective measures enabling any hospital to reduce both anemia and red blood cell transfusions in surgical and medical patients. This article provides comprehensive bundles of PBM components encompassing 107 different PBM measures, divided into 6 bundle blocks acting as a working template to develop institutions' individual PBM practices for hospitals beginning a program or trying to improve an already existing program. A stepwise selection of the most feasible measures will facilitate the implementation of PBM. In this manner, PBM represents a new quality and safety standard.

show abstract

“…The technique has become widely used in a variety of surgical procedures and is highly effective in saving blood and reducing complications (Adias et al, 2006). Oncologic surgery is often accompanied by blood loss that requires massive blood transfusion (Kumar et al, 2014). Allogeneic blood transfusion (ABT) is often used for replenishing blood lost in tumor surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Allogeneic blood transfusion (ABT) is often used for replenishing blood lost in tumor surgery. However, ABT is associated with many complications such as postoperative infection, pulmonary complications, and poor outcomes, especially the promotion of tumor recurrence in oncological surgery (Kumar et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Cisplatin combined with hyperthermia kills HepG2 cells in intraoperative blood salvage but preserves the function of erythrocytes

Yang

Tang

Liu

et al. 2015

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:The safe use of intraoperative blood salvage (IBS) in cancer surgery remains controversial. Here, we investigated the killing effect of cisplatin combined with hyperthermia on human hepatocarcinoma (HepG2) cells and erythrocytes from IBS in vitro. HepG2 cells were mixed with concentrated erythrocytes and pretreated with cisplatin (50, 100, and 200 μg/ml) alone at 37 °C for 60 min and cisplatin (25, 50, 100, and 200 μg/ml) combined with hyperthermia at 42 °C for 60 min. After pretreatment, the cell viability, colony formation and DNA metabolism in HepG2 and the Na + -K + -ATPase activity, 2,3-diphosphoglycerate (2,3-DPG) concentration, free hemoglobin (Hb) level, osmotic fragility, membrane phosphatidylserine externalization, and blood gas variables in erythrocytes were determined. Pretreatment with cisplatin (50, 100, and 200 μg/ml) combined with hyperthermia (42 °C) for 60 min significantly decreased HepG2 cell viability, and completely inhibited colony formation and DNA metabolism when the HepG2 cell concentration was 5×10 4 ml −1 in the erythrocyte (P<0.01). Erythrocytic Na + -K + -ATPase activity, 2,3-DPG level, phosphatidylserine externalization, and extra-erythrocytic free Hb were significantly altered by hyperthermia plus high concentrations of cisplatin (100 and 200 μg/ml) (P<0.05), but not by hyperthermia plus 50 μg/ml cisplatin (P>0.05). In conclusion, pretreatment with cisplatin (50 μg/ml) combined with hyperthermia (42 °C) for 60 min effectively eliminated HepG2 cells from IBS but did not significantly affect erythrocytes in vitro.

show abstract

Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review

Cited by 70 publications

References 57 publications

Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?

Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?

Patient Blood Management Bundles to Facilitate Implementation

Cisplatin combined with hyperthermia kills HepG2 cells in intraoperative blood salvage but preserves the function of erythrocytes

Contact Info

Product

Resources

About