Minimal Clinically Important Differences in Pharmacological Trials

Jones, Paul; Beeh, Kai Michael; Chapman, Kenneth R.; Decramer, Marc; Mahler, Donald A.; Wedzicha, Jadwiga A.

doi:10.1164/rccm.201310-1863pp

Cited by 384 publications

(348 citation statements)

References 49 publications

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“…Our MID results were obtained in the context of a pharmacological intervention and as such may not be applicable to other types of interventions [13], although it has been argued that the same MID values should be applied irrespective of the intervention [29]. All patients involved in this clinical trial had a background therapy of tiotropium and whether this may have influenced the MID results is uncertain.…”

Section: Determination Of Mid Values For Eswtmentioning

confidence: 91%

Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD

et al. 2014

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This study focused on repeatability data and minimal important difference (MID) estimates of the endurance shuttle walking test (ESWT).255 chronic obstructive pulmonary disease patients (forced expiratory volume in 1 s 54.7¡13.2% predicted) completed four ESWTs at different times during the 8-week study: two under baseline conditions with tiotropium (1 week apart), one after a single dose and one after 4 weeks of either fluticasone propionate/salmeterol combination or placebo in addition to tiotropium. 97 patients performed all the tests with a portable metabolic system. Reproducibility of test performance and cardiorespiratory response was investigated with the data obtained on the first two ESWTs.The mean differences between the first two ESWT performances (-6.7¡72.2 s and -7.3¡113.1 m for endurance time and walking distance, respectively) were not statistically significant. The between-test end-exercise and isotime values for each cardiorespiratory parameter were not significantly different from each other. With the exception of arterial oxygen saturation by pulse oximetry, the repeatability of cardiorespiratory adaptations to ESWT was also confirmed with strong Pearson and intraclass correlation coefficients. Finally, changes of 56-61 s and 70-82 m in endurance time and distance walked, respectively, were perceived by patients.This study provides methodological information supporting the reliability of the ESWT and suggests MID estimates for this test.@ERSpublications This study provides a prospective validation of ESWT reliability and minimal important difference in COPD

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Section: Determination Of Mid Values For Eswtmentioning

confidence: 91%

Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD

et al. 2014

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“…Values for both beta-blockers were lower on 8 ICS vs ICS/LABA (Table 3), while for bisoprolol values were also lower on ICS/LABA vs ICS/LABA/LAMA. Changes in TDI were less than the minimal important difference of 1.0 unit (17).…”

Section: Health Status and Dyspnoea Indexmentioning

confidence: 67%

“…For health status as SGRQ (Table 3) there were no significant changes from baseline and no differences between beta-blockers, with reference to a minimal important difference of 4 units (17).…”

Section: Health Status and Dyspnoea Indexmentioning

confidence: 95%

Cardiopulmonary interactions with beta-blockers and inhaled therapy in COPD

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Anderson

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et al. 2017

QJM: An International Journal of Medicine

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“…Yürüme testleri için hastanın algılayabildiği minimum değişiklik (minimal clinically important difference) değerleri farklı tedavilerin etkilerinin karşılaştırılmasında kullanılmaktadır. Artan hızda mekik yürüme testi için ise 48 m olarak bulunmuştur (15,16).…”

Section: Altı Dakika Yürüme Testiunclassified

Egzersi̇z Fi̇zyoloji̇si̇ Ve Egzersi̇z Testleri̇

Şen¹

2017

Bulletin of Thoracic Surgery

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During exercise, metabolic demand of skeletal muscles need to be required by the changes of ventilation, cardiac output, pulmonary and systemic circulation in order to provide oxygenation and to prevent the acid-base status of the body. Exercise tests are used to determine the functional exercise capacity, predict the prognosis, evaluate the clinical study results and assess the treatment response in chronic lung diseases. Cardiopulmonary exercise testing and field tests (incremental shuttle walking test, endurance shuttle walking test, six minute walking test) are currently used. Among them, the most common used exercise test is the six minute walking test. Stair climbing test, incremental shuttle walking test and cardiopulmonary exercise testing are recommended to assess the lung cancer patients who are candidates for lung resection. A cardiopulmonary exercise test is indicated when the postoperative predicted (ppo) FEV 1 or ppo DL CO (or both) are < 30% or when the performance of the stair-climbing test or the shuttle walk test is not satisfactory. A peak oxygen consumption (VO 2 peak) < 10 mL/kg/min or 35% predicted indicates a high risk of mortality and long-term disability for major anatomic resection. Conversely, a VO 2 peak > 20 mL/kg/min or 75% predicted indicates a low risk. Six minute walking test can not be recommended as a standart exercise testing tool since there is a lack of data in the preoperative assessment for lung resection.

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Minimal Clinically Important Differences in Pharmacological Trials

Cited by 384 publications

References 49 publications

Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD

Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD

Cardiopulmonary interactions with beta-blockers and inhaled therapy in COPD

Egzersi̇z Fi̇zyoloji̇si̇ Ve Egzersi̇z Testleri̇

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