Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (<scp>LN</scp>s) and <scp>LN</scp>s with an early invasive component

Atypical hyperplasia and lobular carcinoma in situ are rare proliferative breast lesions, growing inside ducts and terminal ducto-lobular units. They represent a marker of increased risk for breast cancer and a non-obligate precursor of malignancy. Evidence available on diagnosis and management is scarce. They are frequently found incidentally associated with other lesions, but can be visible through mammography, ultrasound or magnetic resonance. Due to the risk of underestimation, surgical excision is often performed. The analysis of imaging and histopathological characteristics could help identifying low-risk cases, for which surgery is not necessary. Chemopreventive agents can be used for risk reduction. Careful imaging follow up is mandatory; the role of breast MRI as screening modality is under discussion.

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Management of atypical lobular hyperplasia, atypical ductal hyperplasia, and lobular carcinoma in situ

Clauser

Marino

Baltzer

et al. 2016

Expert Review of Anticancer Therapy

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Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with an early invasive component

Abstract: Wide extension and higher proliferation activity were characteristic features of symptomatic LNs and LNs with early invasion.

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Management of atypical lobular hyperplasia, atypical ductal hyperplasia, and lobular carcinoma in situ

Management of atypical lobular hyperplasia, atypical ductal hyperplasia, and lobular carcinoma in situ

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