Effects of the antibiotic enrofloxacin on the ecology of tropical eutrophic freshwater microcosms

Rico, Andreu; Dimitrov, Maurício R.; Wijngaarden, R.P.A. van; Satapornvanit, Kriengkrai; Smidt, Hauke; Brink, Paul J. Van den

doi:10.1016/j.aquatox.2013.12.008

Cited by 59 publications

(34 citation statements)

References 44 publications

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“…In the environment, antibiotic degradation includes diverse processes such as biodegradation, evaporation, and sorption to organic matter. For studies where it was reported, antibiotic concentrations decreased by 62 to 100 % during the experiments: 66-100 % in soil (Kotzerke et al 2008), 62-93 % in sediment , and 64-98 % in water (Rico et al 2014). Although antibiotics have low volatilities and do not tend to bioaccumulate, they show variable adsorption capacities and decay rates (half-lives from hours to months and even to years in a solid matrix).…”

Section: Effects On Biogeochemical Processesmentioning

confidence: 90%

“…Across studies, the fate of the antibiotic substance during the experiment was often unconsidered, and only 40 % of the studies quantified the antibiotic concentration in the experimental medium to determine the effect on a certain process (Ahmad et al 2014;Campos et al 2001;Hansen et al 1992;Hou et al 2015;Kotzerke et al 2008;Kotzerke et al 2011;Liu et al 2014;Rico et al 2014 Effective concentration Effective concentration Rosendahl et al 2012;Thiele-Bruhn and Beck 2005;Yan et al 2013). Regardless the antibiotic family, these studies revealed considerable loss of antibiotics over the experiment.…”

Section: Effects On Biogeochemical Processesmentioning

confidence: 96%

“…The duration of the exposure of colistin used by Bressan et al (2013) on ammonia-oxidizing bacteria was 5 h. Schmidt et al (2012) already stated that Binhibition of cell division or protein biosynthesis may be observed only after test duration of several days.^The importance of incubation time was also shown in the BSubstrate Induced Respiration (SIR)^test of Thiele-Bruhn and Beck (2005); no effect was observed after 4 h, whereas respiration was inhibited by both oxytetracycline and sulfapyridine after 24 h. Short-term experiments that are shorter than the growth rate of the targeted bacteria, therefore, explore the effect of the antibiotic on enzyme activity. Studies regarding short-term effects (Bressan et al 2013;Costanzo et al 2005;Hou et al 2015;Katipoglu-Yazan et al 2013) can be contrasted to long-term effect studies: from days (Ahmad et al 2014;Alighardashi et al 2009;Conkle and White 2012;Fountoulakis et al 2004;Hou et al 2015;Ingvorsen et al 2003;Thiele-Bruhn and Beck 2005;Yamamura et al 2014), weeks (Campos et al 2001;Cui et al 2014;Klaver and Matthews 1994;Kotzerke et al 2008;Kotzerke et al 2011;Lotti et al 2012;Rico et al 2014;Roose-Amsaleg et al 2013;Toth et al 2011;Underwood et al 2011;Wunder et al 2013;Yan et al 2013), months (Fernandez et al 2009;Hansen et al 1992;Näslund et al 2008;Rosendahl et al 2012), to a year (442 days by Schmidt et al 2012). Conducting experiments for extended time periods is difficult because degradable antibiotics, as well as nutrients, can be quickly consumed unless continuously added …”

Section: Duration Of the Experiments: Short-term Versus Long-term Effmentioning

confidence: 97%

“…Moreover, most antibiotics are not metabolized and are released into the environment via urine and feces. Concentrations of antibiotics can reach several mg/kg of sediment, especially in aquatic ecosystems downstream of manufacturing plants (see review in Larsson 2014) or aquaculture farms (e.g., Rico et al 2014). Even in other environments such as river water or sediment, antibiotics often occur at concentrations from ng/L to μg/L or μg/kg.…”

Section: Background and Purposesmentioning

confidence: 99%

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Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

Roose‐Amsaleg

Laverman²

2015

Environ Sci Pollut Res

166

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Antibiotic use in the early 1900 vastly improved human health but at the same time started an arms race of antibiotic resistance. The widespread use of antibiotics has resulted in ubiquitous trace concentrations of many antibiotics in most environments. Little is known about the impact of these antibiotics on microbial processes or "non-target" organisms. This mini-review summarizes our knowledge of the effect of synthetically produced antibiotics on microorganisms involved in biogeochemical cycling. We found only 31 articles that dealt with the effects of antibiotics on such processes in soil, sediment, or freshwater. We compare the processes, antibiotics, concentration range, source, environment, and experimental approach of these studies. Examining the effects of antibiotics on biogeochemical processes should involve environmentally relevant concentrations (instead of therapeutic), chronic exposure (versus acute), and monitoring of the administered antibiotics. Furthermore, the lack of standardized tests hinders generalizations regarding the effects of antibiotics on biogeochemical processes. We investigated the effects of antibiotics on biogeochemical N cycling, specifically nitrification, denitrification, and anammox. We found that environmentally relevant concentrations of fluoroquinolones and sulfonamides could partially inhibit denitrification. So far, the only documented effects of antibiotic inhibitions were at therapeutic doses on anammox activities. The most studied and inhibited was nitrification (25-100 %) mainly at therapeutic doses and rarely environmentally relevant. We recommend that firm conclusions regarding inhibition of antibiotics at environmentally relevant concentrations remain difficult due to the lack of studies testing low concentrations at chronic exposure. There is thus a need to test the effects of these environmental concentrations on biogeochemical processes to further establish the possible effects on ecosystem functioning.

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Section: Effects On Biogeochemical Processesmentioning

confidence: 90%

Section: Effects On Biogeochemical Processesmentioning

confidence: 96%

Section: Duration Of the Experiments: Short-term Versus Long-term Effmentioning

confidence: 97%

Section: Background and Purposesmentioning

confidence: 99%

See 2 more Smart Citations

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

Roose‐Amsaleg

Laverman²

2015

Environ Sci Pollut Res

166

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“…Those microcosms have been used as a valuable tool for the higher-tier risk assessment of pesticides (Daam et al, 2008(Daam et al, , 2009Hayasaka et al, 2012a;Halstead et al, 2014;Hua and Relyea, 2014; and veterinary medicines (Rico et al, 2014) over the past decades. There are multiple advantages of using microcosms for toxicity studies, since they allow replications, ecological realism, and are a good tool for validating safety factors used at lower-tier of the risk assessment (Daam and Van den Brink, 2010;Van den Brink, 2013).…”

Section: Sensitivity Differences Between Tropical and Temperate Aquatmentioning

confidence: 99%

Effects of insecticides on aquatic ecosystems in Bangladesh

Sumon

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Implications of fluoroquinolone contamination for the aquatic environment—A review

Janecko

Pokludová

Blahová

et al. 2016

Enviro Toxic and Chemistry

161

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Until recently, the behaviors of antibiotics and their ecotoxicological impact have been overlooked in the environment. The topic is broad and encompasses a wide range of organisms including microorganisms, algae, invertebrates, and vertebrates inhabiting various aquatic ecosystems. Changing the equilibrium of any 1 component in such systems disrupts the balance of the whole system. The manufacturing and frequent use of fluoroquinolones in human and animal medicine raises great concern over the increase of antibiotic resistance prevalence in microorganisms; however, in addition, the fate of antibiotic parent and metabolite compounds entering environmental ecosystems through various pathways raises environmental impact concerns. Research has focused on the concentration of antibiotics present in environmental samples and the acute toxicity to organisms by way of animal assessment models; however, it remains unclear what role low-level chronic exposure plays in ecotoxicological effects on lifeforms in aquatic environments. The aim of the present review was to assess the levels of fluorquinolone use in animal and human medicine, to determine the pathways of dissemination, and to highlight the ecotoxicological implications in freshwater environments. Environ Toxicol Chem 2016;35:2647-2656. # 2016 SETAC

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Effects of the antibiotic enrofloxacin on the ecology of tropical eutrophic freshwater microcosms

Cited by 59 publications

References 44 publications

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

Effects of insecticides on aquatic ecosystems in Bangladesh

Implications of fluoroquinolone contamination for the aquatic environment—A review

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