Effects of Water Extracts ofGraptopetalum paraguayenseon Blood Pressure, Fasting Glucose, and Lipid Profiles of Subjects with Metabolic Syndrome

Abstract

This study was aimed to investigate the effects of water extracts of Graptopetalum paraguayense (WGP, 4 g/d) on blood pressure, blood glucose level, and lipid profiles in subjects with metabolic syndrome (MS). Participants with MS (n = 54) were randomly assigned to the placebo (n = 28) and WGP groups (n = 26), and the intervention was administered for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose (FG), lipid profiles (total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein (HDL-C)), and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) were measured. Forty-two subjects completed the study (placebo, n = 19; WGP, n = 23). FG, SBP, and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities (CAT and SOD) were significantly higher after WGP supplementation. Blood pressure, FG, and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation (P < 0.05). The present study demonstrated a significant reduction in blood pressure, blood glucose, and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation. Taken together, the antioxidative capacity of WGP might exert a beneficial effect on MS. This trial is registered with ClinicalTrials.gov NCT01463748.

Anti‐inflammatory effect of water extracts of Graptopetalum paraguayense supplementation in subjects with metabolic syndrome: a preliminary study

“…In our previous study, we found a significant reduction in blood glucose and lipid profiles after WGP supplementation in the subjects with MS. Additionally, in the present study; we demonstrated anti‐inflammatory effects of WGP. Based on these results, we suppose that WGP exerts these beneficial effects on MS because of its antioxidant capacity . It is interesting to note that some of our subjects in this study were under anti‐diabetic, antihypertensive, or lipid‐lowering medications (Table ), but the proportion of medications was not significantly different between the placebo and WGP groups.…”

“…Many studies have demonstrated its biological activities, including the inhibition of tyrosinase, the prevention of lipid peroxidation; and its antihypertensive, hepatoprotective, and neuroprotective effects . Recently, we demonstrated that water extract of G. paraguayense (WGP) could significantly reduce the levels of blood pressure, blood glucose, and blood lipids in MS patients . As MS is considered to be a chronic inflammatory status, it is worth to examine the anti‐inflammatory effect of G. paraguayense in MS patients.…”

Anti-Glycation of Active Compounds Purified from G raptopetalum Paraguayense

“…; Yen et al . ). Carboxymethyllysine (CML) is an advanced glycation end product (AGE) that causes pancreatic damage, and diabetes can be controlled by G. paraguayense (Lee et al .…”

“…; Yen et al . ). In diabetic patients, a high methylglyoxal concentration in the blood was found to be positively correlated with hyperglycemia (Cheng et al .…”

“…; Yen et al . ). AGEs are regarded as the molecular outcomes of posttranslational modification of proteins (Brownlee et al .…”