Tomographie par cohérence optique plein champ des biopsies de la prostate : un pas vers le diagnostic pré-histologique ?

Beuvon, Frédéric; Dalimier, Eugénie; Cornud, F.; Delongchamps, Nicolas Barry

doi:10.1016/j.purol.2013.05.008

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…As compared to confocal systems, FFOCT further holds the advantage not to require lasers or fast scanning elements; the technique can be integrated in a simple setup. The FFOCT has already been evaluated in the pathology laboratory in various preclinical studies on human skin, 24,25 pulmonary, 26 urologic, 27 and gastrointestinal tissue, 28 retina and cornea, 29,30 and brain. 31 Recently, a preclinical study was performed on breast tissue samples 32 and achieved sensitivity of 92% and specificity of 77%.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

Grieve

Mouslim

Assayag

et al. 2015

Technol Cancer Res Treat

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Current techniques for the intraoperative analysis of sentinel lymph nodes during breast cancer surgery present drawbacks such as time and tissue consumption. Full-field optical coherence tomography is a novel noninvasive, high-resolution, fast imaging technique. This study investigated the use of full-field optical coherence tomography as an alternative technique for the intraoperative analysis of sentinel lymph nodes. Seventy-one axillary lymph nodes from 38 patients at Tenon Hospital were imaged minutes after excision with full-field optical coherence tomography in the pathology laboratory, before being handled for histological analysis. A pathologist performed a blind diagnosis (benign/malignant), based on the full-field optical coherence tomography images alone, which resulted in a sensitivity of 92% and a specificity of 83% (n ¼ 65 samples). Regular feedback was given during the blind diagnosis, with thorough analysis of the images, such that features of normal and suspect nodes were identified in the images and compared with histology. A nonmedically trained imaging expert also performed a blind diagnosis aided by the reading criteria defined by the pathologist, which resulted in 85% sensitivity and 90% specificity (n ¼ 71 samples). The number of false positives of the pathologist was reduced by 3 in a second blind reading a few months later. These results indicate that following adequate training, full-field optical coherence tomography can be an effective noninvasive diagnostic tool for extemporaneous sentinel node biopsy qualification.

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Section: Introductionmentioning

confidence: 99%

Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

Grieve

Mouslim

Assayag

et al. 2015

Technol Cancer Res Treat

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show abstract

“…have recently tested the feasibility of OCT in prostate biopsies for diagnostic purposes and reported a 81% concordance with histopathological findings. [42] OCT might have a potential role in the future both in the diagnostic and the therapeutic pathways.…”

Section: Introductionmentioning

confidence: 99%

Newer concepts in neural anatomy and neurovascular preservation in robotic radical prostatectomy

et al. 2014

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With more than 60% of radical prostatectomies being performed robotically, robotic-assisted laparoscopic prostatectomy (RALP) has largely replaced the open and laparoscopic approaches and has become the standard of care surgical treatment option for localized prostate cancer in the United States. Accomplishing negative surgical margins while preserving functional outcomes of sexual function and continence play a significant role in determining the success of surgical intervention, particularly since the advent of nerve-sparing (NS) robotic prostatectomy. Recent evidence suggests that NS surgery improves continence in addition to sexual function. In this review, we describe the neuroanatomical concepts and recent developments in the NS technique of RALP with a view to improving the “trifecta” outcomes.

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The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

et al. 2019

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Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology. Three experts assessed all the corresponding OCT images. The OCT and biopsy conclusions for the corresponding regions were compared. Results No adverse events during and following the, in total four, in vivo needle‐based OCT measurements were reported. The OCT measurements showed images of prostatic tissue with a penetration depth of ~1.5 mm. The histological‐proven tissue types, which were also found in the overlapping OCT images, were benign glands, stroma, glandular atrophy, and adenocarcinoma (Gleason pattern 3). Conclusions Clinical in vivo needle‐based OCT of the prostate is feasible with no adverse events during measurements. OCT images displayed detailed prostatic tissue with a imaging depth up to ~1.5 mm. We could co‐register four histological‐proven tissue types with OCT images. The feasibility of in vivo OCT in the prostate opens the pathway to the next phase of needle‐based OCT studies in the prostate. Lasers Surg. Med. 51:390–398, 2019. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.

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Tomographie par cohérence optique plein champ des biopsies de la prostate : un pas vers le diagnostic pré-histologique ?

Cited by 10 publications

References 23 publications

Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

Newer concepts in neural anatomy and neurovascular preservation in robotic radical prostatectomy

The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

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