Maternal–Fetal Transmission of Hepatitis C Infection

Wen, Jessica; Haber, Barbara

doi:10.1097/mpg.0000000000000258

Cited by 17 publications

(15 citation statements)

References 52 publications

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“…In Mexico, we did not find a previous study assessing the HCV seroprevalence in pregnant women; therefore, this study is the first, and the result (1.4%) was within the global range. 29,30 Since 70% of women with anti-HCV antibodies are expected to have viremia, and 4.3% of them transfer the infection to their babies, we expect that approximately 4 per 10,000 newborns would acquire the infection. 30 Compared to CMV and T. gondii, an HCV congenital infection would be much less frequent, although specific studies must be conducted before any conclusions are made, since official reports about its incidence in women suggest that it is more frequent than rubella, HBV, syphilis and HIV.…”

Section: Discussionmentioning

confidence: 99%

Frequency of risk infections for congenital infection in pregnant women

et al. 2021

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BACKGROUND: TORCH and other infections can be vertically transmitted and provoke abortions or result in congenitally infected newborns. Most babies are born with subclinical infection but have a high risk of developing sequalae later. OBJECTIVE:To determine the frequency of seven endemic infections that represent risk for vertical transmission among pregnant women of a tertiary care hospital. MATERIALS AND METHODS:Prospective, cross-sectional study carried out in pregnant women attended at the INPer between 2010 and 2012. Infections were investigated by serological risk markers among pregnant women living in the Valley of Mexico and answered a questionnaire including risk factors. RESULTS:A total of 1079 pregnant women were studied, and the overall frequency of infection was 5.7%. Anti-Toxoplasma gondii low avidity IgG (2.0%) and parvovirus B19 IgM (2.0%) were the most common. No HBV S-Ag and one rubella case were detected. An association of markers studied with fetal malformations and transfusions (p < 0.015) was found. Toxoplasma infection was associated with the last two variables, as well as with the consumption of raw meat, previous positive TORCH and infection with HPV. Parvovirus B19 IgM was associated with stillbirths, and T. pallidum with HIV. Four cases had double infections. CONCLUSIONS:This study supports the success of vaccination control programs against rubella and active HBV, although infections or perinatal risk are still challenging for this group of women and their children´s health.

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Section: Discussionmentioning

confidence: 99%

Frequency of risk infections for congenital infection in pregnant women

et al. 2021

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“…For this reason, routine screening for HBsAg is recommended during pregnancy in the prenatal period (2,6,8,16). Routine prenatal HCV screening is not recommended because there is no proven vaccine, intervention, or approved treatment to reduce or prevent vertical transmission of HCV infection (12,18,19). In general, screening for HCV infection is recommended for pregnant women having risk factors for hepatitis C, such as HIV infection and intravenous drug use (12,20).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis B Surface Antigen, Anti-Hepatitis B Surface and Anti-Hepatitis C Virus Among Pregnant Women Residing in Şırnak Province

Sahin¹,

Zencir²,

Gözübüyük³

et al. 2018

vhd

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Objectives: The purpose of the study was to detect the rate of hepatitis B surface antigen (HBsAg), anti-HBs and anti-hepatitis C virus (HCV) seropositivity among pregnant women residing in the city of Şırnak. Materials and Methods: Results of serological tests for HBsAg, anti-HBs and anti-HCV in 2214 pregnant women, who were admitted to the Gynecology and Obstetrics Clinics and Emergency Departments at Şırnak State Hospital and Cizre State Hospital between the dates of April 1, and October 1, 2017, were retrospectively evaluated. Results: A total of 2214 pregnant women were included in this study. It was determined that the rate of seropositivity for HBsAg, anti-HBs and anti-HCV was 1%, 27.8%, and 0.21%, respectively. It was found that anti-HBs seropositivity rate among pregnant women younger than 19 years was 54.5%, which was higher than in those aged 19 years or older. Conclusion: Anti-HCV positivity rate detected in pregnant women who resided in Şırnak was found to be similar to the results reported in other studies conducted in our country, however, HBsAg positivity rate was found to be lower when compared with the results of other studies. A significant increase was detected in anti-HBs seropositivity rate in Şırnak since hepatitis B vaccine was included in the national immunization schedule.

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“…79,80 Importantly, post-partum HCV transmission is not thought to occur with breastfeeding and the current recommendations are that breastfeeding should not be discouraged based on a positive HCV infection status; an exception being if the mother is co-infected with HIV. 78,[81][82][83][84] Although the rate of MTCT of HCV has remained stable at 5%-6%, the incidence of HCV infection among women of child-bearing age is increasing. 56,60,85 In the US, 1%-2.5% of pregnant women are infected with HCV.…”

Section: Screening During Pregnancymentioning

confidence: 99%