Maternal serum AGEs levels in pregnancies associated with neural tube defects

Li, Rulin; Yang, Peng; Chen, Xuyang; Wang, Li

doi:10.1016/j.ijdevneu.2013.12.002

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…Consequently, mammals have evolved homoeostatic mechanisms that maintain blood and tissue concentrations of glucose within very narrow physiological limits. The AGEs have been implicated in reproductive conditions such as ovarian hyperstimulation syndrome and PCOS [ 47 ], and glycated proteins have been implicated in the fetal malformations that can accompany diabetic pregnancy [ 48 , 49 ].…”

Section: Glucosementioning

confidence: 99%

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

Dupont

Scaramuzzi

2016

Biochemical Journal

155

104

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Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin signals via diverse interconnecting intracellular pathways and that some of the major intersecting points (known as critical nodes) are the IRSs (insulin receptor substrates), PI3K (phosphoinositide kinase)/Akt and MAPK (mitogen-activated protein kinase). Most of these insulin pathways are probably also active in the ovary and their ability to interact with each other and also with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) signalling pathways enables insulin to exert direct modulating influences on ovarian function. The present paper reviews the intracellular actions of insulin and the uptake of glucose by ovarian tissues (granulosa, theca and oocyte) during the oestrous/menstrual cycle of some rodent, primate and ruminant species. Insulin signals through diverse pathways and these are discussed with specific reference to follicular cell types (granulosa, theca and oocyte). The signalling pathways for FSH in granulosa cells and LH in granulosa and theca cells are summarized. The roles of glucose and of insulin-mediated uptake of glucose in folliculogenesis are discussed. It is suggested that glucose in addition to its well-established role of providing energy for cellular function may also have insulin-mediated signalling functions in ovarian cells, involving AMPK (AMP-dependent protein kinase) and/or hexosamine. Potential interactions of insulin signalling with FSH or LH signalling at critical nodes are identified and the available evidence for such interactions in ovarian cells is discussed. Finally the action of the insulin-sensitizing drugs metformin and the thiazolidinedione rosiglitazone on follicular cells is reviewed.

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Section: Glucosementioning

confidence: 99%

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

Dupont

Scaramuzzi

2016

Biochemical Journal

155

104

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“…AGEs are thought to play a role in preeclampsia (33), and high sAF was reported in former preeclamptic women (34), but they may result from, rather than precede, preeclampsia (35); in our study, blood pressures during pregnancy were not associated with macrosomia. The role of AGEs has also been suspected in neural tube defects (36) and autism (37) that have been related to diabetic pregnancies (38,39). Some limitations of our study must be kept in mind.…”

Section: Discussionmentioning

confidence: 95%

Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children

et al. 2019

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Advanced glycation end products (AGEs) accumulated during long-term hyperglycemia are involved in diabetes complications and can be estimated by skin autofluorescence (sAF). During pregnancy, hyperglycemia exposes women to the risk of having a macrosomic newborn. The aim of this study was to determine whether sAF of women with diabetes during a singleton pregnancy could predict macrosomia in their newborns. Using an AGE Reader, we measured the sAF at the first visit of 343 women who were referred to our diabetology department during years 2011-2015. Thirty-nine women had pregestational diabetes, 95 early gestational diabetes mellitus (GDM), and 209 late GDM. Macrosomia was defined as birth weight ‡4,000 g and/or large for gestational age ‡90th percentile. Forty-six newborns were macrosomic. Their mothers had 11% higher sAF compared with other mothers: 2.03 6 0.30 arbitrary units (AUs) vs. 1.80 6 0.34 (P < 0.0001). Using multivariate logistic regression, the relation between sAF and macrosomia was significant (odds ratio 4.13 for 1-AU increase of sAF [95% CI 1.46-11.71]) after adjusting for several potential confounders. This relation remained significant after further adjustment for HbA 1c (among 263 women with available HbA 1c ) and for women with GDM only. sAF of pregnant women with diabetes, a marker of long-term hyperglycemic exposure, predicts macrosomia in their newborns.

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Chromium levels in placental tissue and neural tube defects: Association and mechanistic study

Chen,

Guo,

Wang

et al. 2024

Environmental Pollution

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Maternal serum AGEs levels in pregnancies associated with neural tube defects

Cited by 8 publications

References 45 publications

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children

Chromium levels in placental tissue and neural tube defects: Association and mechanistic study

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