The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients

Turkcu, Ummuhani Ozel; Tekin, Nilgün Solak; Edgünlü, Tuba Gökdoğan; Karakaş, Sevim; Öner, Setenay

doi:10.1016/j.gene.2013.11.055

Cited by 34 publications

(42 citation statements)

References 46 publications

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“…Three studies were performed (182 patients). Two studies detected higher circulating AOPP while one study mentioned no difference …”

Section: Resultsmentioning

confidence: 99%

“…Overall, CAT is downregulated in vitiligo. Forkhead box O3 (FOXO3) is a protein that regulates both CAT and SOD2 expression and was decreased in one study …”

Section: Resultsmentioning

confidence: 99%

“…Also by several fundamental research groups, the oxidative pathway is considered as one of the initial steps in the development of vitiligo. The production of chemokines and inflammatory cytokines, and recruitment of immune cells induced by oxidative stress have been extensively investigated . Unfortunately, the role of inflammation in generating oxidative stress has a lot less been investigated in vitiligo.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Speeckaert

Dugardin

Lambert

et al. 2018

Acad Dermatol Venereol

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“…Three studies were performed (182 patients). Two studies detected higher circulating AOPP while one study mentioned no difference …”

Section: Resultsmentioning

confidence: 99%

“…Overall, CAT is downregulated in vitiligo. Forkhead box O3 (FOXO3) is a protein that regulates both CAT and SOD2 expression and was decreased in one study …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Speeckaert

Dugardin

Lambert

et al. 2018

Acad Dermatol Venereol

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show abstract

“…In order to see how these variants translate into physiological profiles, future investigations should address how these variants affect the level of FOXO proteins and their downstream effectors in serum. This approach has been used successfully in patients with vitiligo, in which FOXO3A levels were shown to be decreased when compared with the control group (Ozel Turkcu et al ., 2014). …”

Section: Discussionmentioning

confidence: 99%

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

2015

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SummaryAging constitutes the key risk factor for age‐related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which “protective genes” are carried by long‐lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin‐like growth factor signaling. Invertebrate genomes have one FOXO gene, while mammals have four FOXO genes: FOXO1, FOXO3, FOXO4, and FOXO6. In mammals, this subfamily is involved in a wide range of crucial cellular processes regulating stress resistance, metabolism, cell cycle arrest, and apoptosis. Their role in longevity determination is complex and remains to be fully elucidated. Throughout this review, the mechanisms by which FOXO factors contribute to longevity will be discussed in diverse animal models, from Hydra to mammals. Moreover, compelling evidence of FOXOs as contributors for extreme longevity and health span in humans will be addressed.

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“…Recently, FOXO3a was found to be an anti-melanogenic factor that mediates antioxidant-induced depigmentation [31]. In addition, a significant relationship between rs4946936 polymorphism of FOXO3a gene and the occurrence of vitiligo has been demonstrated [32]. Because FOXO3a is modulated by SIRT1, it was hypothesized that resveratrol may increase SIRT1 and the following activation of FOXO3a may be a mechanism of depigmenting effects of resveratrol.…”

Section: Discussionmentioning

confidence: 99%

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation

Kwon

Choi

Kang

et al. 2017

IJMS

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Resveratrol exhibits not only anti-melanogenic property by inhibiting microphthalmia-associated transcription factor (MITF), but also anti-aging property by activating sirtuin-1 (SIRT1). In this study, the relationship between depigmenting effect of resveratrol and SIRT1/forkhead box O (FOXO) 3a activation and was investigated. Resveratrol suppressed melanogenesis by the downregulation of MITF and tyrosinase via ERK pathway. Results showed that the expression of both SIRT1 and FOXO3a were increased. It is reported that SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. However in our study, FOXO3a activation appeared earlier than that of SIRT1. Furthermore, the effect of resveratrol on the levels of MITF and tyrosinase was suppressed when melanocytes were pre-treated with SP600125 (JNK inhibitor). However, pre-treatment with SIRT1 inhibitor (EX527, or sirtinol) did not affect the levels of MITF and tyrosinase. Therefore, resveratrol inhibits melanogenesis through the activation of FOXO3a but not by the activation of SIRT1. Although SIRT1 activation by resveratrol is a well-known mechanism of resveratrol-induced antiaging effects, our study showed that not SIRT1 but FOXO3a activation is involved in depigmenting effects of resveratrol.

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The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients

Cited by 34 publications

References 46 publications

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation

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