Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Viola, Thiago Wendt; Tractenberg, Saulo Gantes; Levandowski, Mateus Luz; Pezzi, Júlio Carlos; Bauer, Moisés Evandro; Teixeira, Antônio Lúcio; Grassi‐Oliveira, Rodrigo

doi:10.1503/jpn.130027

Cited by 33 publications

(52 citation statements)

References 75 publications

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“…This finding corroborates previous studies that showed higher BDNF concentrations in CCD [9,25,37]. The increase of plasma BDNF levels during early abstinence might suggest a form of neuromodulation of the central nervous system in response to the crack/cocaine neurotoxicity [38], acting in an effort to recover the brain from the neuronal damage caused by chronic drug use [39].…”

Section: Discussionsupporting

confidence: 90%

“…In the context of crack/cocaine addiction, there are evidences demonstrating that individuals with addiction to drugs perform poorly in neuropsychological tasks regarding attention, inhibitory control, executive functions and declarative memory [4,5,6,7,8]. These cognitive deficits seem to be related with structural and functional alterations in the brain, as well as altered levels of cellular and molecular neurobiological markers [9,10]. …”

Section: Introductionmentioning

confidence: 99%

“…Higher peripheral BDNF levels have also been reported [9,24,25], including sustained elevated BDNF levels in response to acute effects of drugs and during periods of drug withdrawal [9,25]. In addition, during cocaine abstinence, higher levels of peripheral BDNF have been associated with relapse vulnerability [26].…”

Section: Introductionmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor and Delayed Verbal Recall in Crack/Cocaine Dependents

et al. 2015

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Background/Aims: Considering the role of brain-derived neurotrophic factor (BDNF) in memory processes and its peripheral response during the detoxification of cocaine, the aim of this study was to investigate whether plasma BDNF levels could be related to memory performance in women with crack/cocaine dependence. Methods: Twenty-five abstinent female crack/cocaine users (CCD) and 25 unmedicated healthy women (HW), carefully matched for age and years of formal education, were assessed regarding memory performance. Logical Memory was used to assess the immediate verbal recall (IVR), delayed verbal recall (DVR) and memory retention. Plasma BDNF levels were measured by Elisa immunoassay. Beck Depression Inventory was used to assess the severity of depressive symptoms, and the Cocaine Selective Severity Assessment the severity of cocaine abstinence symptoms. Results: The CCD group had lower DVR scores and higher plasma BDNF levels when compared to HW group. In addition, a linear regression model showed that BDNF levels predicted DVR scores within CCD group independently of depressive symptoms (R = 0.51; R² = 0.26; t(22) = 4.025, p = 0.03). Conclusion: Despite higher plasma BDNF levels, crack users exhibited memory impairments when compared to healthy women. Specifically, peripheral BDNF levels predicted better cognitive performance only within individuals who already had cognitive impairment.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor and Delayed Verbal Recall in Crack/Cocaine Dependents

et al. 2015

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“…Long-term cocaine use contributes to important health problems, including coronary artery disease (Degenhardt et al, 2011), major depressive disorder (Herrero, Domingo-Salvany, Torrens, Brugal, & Investigators, 2008), cognitive decline (Verdejo-Garcia, Perez-Garcia, Sanchez-Barrera, Rodriguez-Fernandez, & Gomez-Rio, 2007;Viola et al, 2015), and. In addition, cocaine use has been associated with increased peripheral inflammatory mediators (Araos et al, 2015;Fox et al, 2012;Levandowski et al, 2014) and age-related atrophy in grey matter volume (Ersche, Jones, Williams, Robbins, & Bullmore, 2013) both of which are commonly seen in association with aging and age-related disorders (Sander et al, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Moreover, high rates of early life trauma have been described among women with crack cocaine dependence and they are often more susceptible to the complications of crack cocaine compared to their male counterparts . Furthermore, women with crack cocaine addiction with a severe ELS history present distinct behavioral (Francke, Viola, Tractenberg, & Grassi-Oliveira, 2013), immune (Levandowski et al, 2013;Levandowski et al, 2014) and neurotrophic (Viola et al, 2014) phenotypes when compared to those without such early life exposure.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Crack cocaine addiction, early life stress and accelerated cellular aging among women

Levandowski

Tractenberg

Azeredo

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Mindfulness‐based program for stress reduction in infertile women: Randomized controlled trial

et al. 2018

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Infertile women often experience chronic stress, which may have a negative impact on general well‐being and may increase the burden of infertility. In this open‐label, parallel, randomized controlled trial, infertile women aged 18–50 years (median 37 years) were assigned to an 8‐week mindfulness‐based program (MBP) or no intervention. The primary outcome was stress severity measured by the Lipp's Stress Symptoms Inventory (ISSL). Data were analyzed by modified intent‐to‐treat principle, which included all cases available to follow‐up regardless of adherence to the intervention (62 participants from the MBP group and 37 from the control group). The median number of symptoms of chronic stress recorded in the past month decreased from six (interquartile range 2 to 9) before the MBP to two (interquartile range 1 to 4) after the intervention (p < 0.001, repeated measures analysis of variance with Time × Group interaction). Depressive symptoms also decreased after MBP, whereas general well‐being improved (p < 0.01 for both outcomes). Hair cortisol and serum brain‐derived neurotrophic factor (BDNF) did not change significantly between preintervention and postintervention. None of the outcomes changed significantly in the control group. MBP was effective in reducing stress and depressive symptoms while increasing general well‐being in infertile women.

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Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Cited by 33 publications

References 75 publications

Brain-Derived Neurotrophic Factor and Delayed Verbal Recall in Crack/Cocaine Dependents

Brain-Derived Neurotrophic Factor and Delayed Verbal Recall in Crack/Cocaine Dependents

Crack cocaine addiction, early life stress and accelerated cellular aging among women

Mindfulness‐based program for stress reduction in infertile women: Randomized controlled trial

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