Cytological and histological correlation in diagnosing feline and canine mediastinal masses

Pintore, Laura; Bertazzolo, Walter; Bonfanti, Ugo; Gelain, Maria Elena; Bottero, Enrico

doi:10.1111/jsap.12161

Cited by 14 publications

(15 citation statements)

References 21 publications

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“…Typical histological appearance of thymoma reveals oval, or spindle-shaped thymic epithelial cells and mature lymphocytes to various extents. However, histology and cytology may not always correlate, with only 28% of cases being definitively confirmed on cytology in a study by Zizt and others, although a recent study found better correlation with 12 out of 17 feline thymomas confirmed on cytology and histology, and the remaining five cases confirmed on histopathology were suspected cytologically in four incidences, but were hindered by sample quality (Pintore and others 2014). HS and thymic epithelial neoplasms may occasionally share similar cytological features, with spindle and discrete cells seen in both forms.…”

Section: Discussionmentioning

confidence: 99%

“…However, neoplasms are more commonly reported and include heart base tumours (eg, chemodectoma), lymphoma, thymoma and, rarely, sarcomas, ectopic thyroid tissue and HS (Zitz and others 2008, Pintore and others 2014). …”

Section: Investigationsmentioning

confidence: 99%

“…The most commonly reported mediastinal neoplasms in cats are lymphoma and thymoma (Zitz and others 2008, Pintore and others 2014). Feline histiocytic disease is rarely reported and, to the authors’ knowledge, there are only two cases of mediastinal histiocytic sarcoma (HS) described in the literature (Walton and others 1997, Smoliga and others 2005).…”

Section: Introductionmentioning

confidence: 99%

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Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Bisson¹,

Steen²,

Hawkins³

et al. 2017

Vet Record Case Reports

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A nine–year-old female neutered Somali cat presented with a one-month history of weight loss and inappetance. Thoracic radiographs revealed an extensive cranial mediastinal mass, and fine needle aspirate cytology and core needle biopsies were initially suggestive of a thymoma. The mass was excised via a mid-ine sternotomy and partial pericardectomy. Clinical signs recurred four weeks postsurgery and investigations revealed recurrence of a mediastinal mass, pleural effusion and an additional small mass cranial to the right kidney. Histopathological examination and immunohistochemistry of the previously resected mass prompted a revised diagnosis of histiocytic sarcoma (HS) with abdominal metastasis. The cat was treated with doxorubicin and lomustine but did not respond well and was euthanased two months later. HS is an uncommon neoplasm in cats with only two cases of mediastinal involvement reported in the literature. This case underlines the importance of immunohistochemistry in the evaluation of mediastinal masses.

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Section: Discussionmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Bisson¹,

Steen²,

Hawkins³

et al. 2017

Vet Record Case Reports

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“…Such lesions are commonly investigated via radiography, ultrasonography, and computer tomography (CT). All these techniques can be helpful to define the volume of the mass and the possible heterogeneity of its structure (1,3), but they are also helpful to guide sampling procedures (fine needle aspirate cytology, FNAC), thus facilitating the investigation of its cellular origin.…”

Section: Introductionmentioning

confidence: 99%

“…A final diagnosis can be reached by cytological or histological examination, but in some cases, it may be challenging and may require further ancillary techniques. Cytology may sometimes be inconclusive because of the poor quality of samples (1) or because both lymphomas and thymomas can be composed by small/medium sized lymphocytes with minimal morphological atypia (4,5). Thus, histopathology of tissue biopsy is often required for a definitive diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Flow Cytometric Analysis of Mediastinal Masses in Cats: A Retrospective Study

Bernardi

Martini

Perfetto³

et al. 2020

Front. Vet. Sci.

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Mediastinal masses occur in dogs and cats and are often investigated with cytology. However, discrimination between the two most common lesions (thymoma and lymphoma) may be challenging, especially when small/medium lymphocytes represent the prevalent population. The aim of the present study is to describe the flow cytometric aspects of mediastinal masses in cats and to assess the ability of flow cytometry (FC) to differentiate lymphoma from non-lymphomatous lesions. We retrospectively describe FC features of fine needle aspiration cytology from cats with mediastinal masses. Cases were grouped in lymphoma and non-lymphoma based on results of cytology, histopathology, PCR for antigen receptor rearrangement (PARR), clinical presentation, and follow-up. Scatter properties, positivities to CD5, CD4, CD8, CD21, CD18, and their co-expressions were recorded using a multicolour approach. Twenty cats were included, 12 lymphomas and eight non-lymphomatous cases. Forward scatter (FSC) of lymphoid cells was higher in the lymphoma group. Double positive CD4+CD8+ T-cells were the dominant population in eight out of 12 lymphomas, whereas non-lymphomatous lesions showed no dominant lymphoid population in five out of eight cases. Unlike dogs, the high prevalence of CD4+CD8+ lymphomas in cats it makes difficult to differentiate lymphoma from non-lymphomatous lesions using FC alone. FC may add interesting information to refine diagnosis in some cases, but PARR and histopathology remain mandatory to solve differential in case of expansion of small-medium sized double positive lymphoid cells.

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Retrospective study of 540 cats with respiratory diseases in Japan (2003–2020)

Fujiwara‐Igarashi,

Ohshima,

Kojima

et al. 2024

Veterinary Medicine & Sci

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BackgroundFew epidemiological studies on respiratory medicine and the relationship between clinical signs and various respiratory diseases in cats have been reported.ObjectivesThis retrospective study aimed to investigate the prevalence and breed predisposition to feline respiratory diseases in Japan and determine the association between clinical signs, duration and type of respiratory diseases.MethodsThe medical records of cats with feline respiratory diseases were examined to obtain information on age, sex, breed, final diagnosis, clinical signs and duration. The odds ratios (ORs) and 95% confidence intervals were calculated to evaluate breed predispositions. Mann–Whitney U, Kruskal–Wallis and Dunn's tests were used to assess the duration of clinical signs.ResultsThis study included 540 cats with 615 respiratory diagnoses. The American Shorthair breed was predisposed to bronchopneumonia (BP; OR: 5.0) and pulmonary tumour (PT; OR: 3.6), while the Russian Blue breed exhibited a predisposition to inflammatory lower airway diseases (OR: 3.4), BP (OR: 6.1) and interstitial lung diseases (OR: 11.1). Similarly, the Scottish Fold breed displayed predisposition to PTs (OR: 5.8). The duration of clinical signs among nasal diseases, nasopharyngeal diseases and lower tracheal/bronchial and pulmonary diseases differed significantly (p = 0.001, p = 0.012, p < 0.0001, respectively).ConclusionsThe results suggest that some popular breeds in Japan are predisposed to feline respiratory diseases, especially the American Shorthair, Russian Blue and Scottish Fold breeds. The characteristics of occurrence, clinical signs and duration of each disease will aid in diagnosing, treating, preventing and elucidating the pathophysiology of feline respiratory disease.

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Cytological and histological correlation in diagnosing feline and canine mediastinal masses

Abstract: Cytological examination of canine and feline mediastinal masses is a relatively easy, low-cost procedure, with good agreement with final histological diagnoses.

Cited by 14 publications

References 21 publications

Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Flow Cytometric Analysis of Mediastinal Masses in Cats: A Retrospective Study

Retrospective study of 540 cats with respiratory diseases in Japan (2003–2020)

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