“…Therefore, the development and exploitation of multi-target drugs might represent an efficient strategy to overcome these clinically relevant point mutations and is becoming increasingly attractive in the repertoire of kinase inhibitors. Thus far, several multi-target drugs have been approved by the U.S. Food and Drug Administration [9], such as lapatinib against HER1 and HER2, imatinib against BCR-Abl, c-Kit, and PDGFR, and sorafenib against B-Raf, VEGFR, PDGFR, and c-Kit, coupled with a large body of multi-target inhibitors access to clinical trails, such as roscovitine against CDK and CK1 [10], PLX647 against FMS and KIT [11], fisetin against PI3K/ Akt and mTOR [12], and MLS-2384 against JAK and Src [13].…”