“…Ectopic expression of full length LRIG1 has been shown to inhibit the growth, motility and/or invasion of a variety of tumor cells, in vitro and in vivo (Laederich et al ., 2004, Shattuck et al ., 2007, Stutz et al ., 2008, Miller et al ., 2008, Ye et al ., 2009, Thomasson et al ., 2011, Li et al ., 2011, Krig et al ., 2011, Wang et al ., 2012, Lu et al ., 2013, Chang et al ., 2013, Qi et al ., 2013), making its potential restoration to LRIG1-deficient tumors of great interest. However, the translational applications of expressing full length LRIG1 are limited at this time due to its large size and membrane-bound nature.…”