The Egg and the Nucleus: A Battle for Supremacy (Nobel Lecture)

Gurdon, J. B.

doi:10.1002/anie.201306722

Cited by 13 publications

(7 citation statements)

References 50 publications

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“…During highly complex and precise processes of cellular proliferation, interactions, differentiation and migration, a zygote becomes a multicellular organism with a variety of cell types. Gene expression patterns, cell signaling and epigenetic modifications lead to these processes (Gurdon, 2013). The process of development from a zygote to a multicellular organism is dynamic in both space and time.…”

Section: Biological Development Of Tissues and Organsmentioning

confidence: 99%

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

et al. 2020

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Section: Biological Development Of Tissues and Organsmentioning

confidence: 99%

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

et al. 2020

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“…These findings reported that the forced expression of certain transcription factors can induce the pluripotency and led to development of effective reprogramming methods of iPS cells [34]. On the other hand, John B Gurdon the co-recipient of 2012 Nobel Prize, worked with eggs and embryos of frogs (Xenopus) and reported reprogramming by nuclear transplantation [35]. These findings improved the understanding of nuclear reprogramming, of embryonic development, and of cellular differentiation.…”

Section: The Induced Pluripotent Stem Cells-2012mentioning

confidence: 95%

“…These findings improved the understanding of nuclear reprogramming, of embryonic development, and of cellular differentiation. Gurdon work has paved the way for regenerative medicine [35,36]; and also this discovery led to the further research in regenerative medicine and reprogramming field.…”

Section: The Induced Pluripotent Stem Cells-2012mentioning

confidence: 99%

Physiology and Medicine: The Gifted Saga of the Last Decade

Rao¹,

Nb²

2016

Anat Physiol

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Over the last century, Science and Technology moved forward and witnessed exceptional inventions and discoveries due to individual and collaborative research efforts. This momentum opened doors for the deep understanding of biological systems by which it permitted the advancement in technologies and designing of new tools in biomedical field. Since 1901, discoveries and inventions in various fields of science (Chemistry, Physics, Physiology and Medicine, Economics) including literature which can influence the betterment of human race were being awarded with Nobel Prize. Over the past decade, numerous groundbreaking discoveries in physiology and medicine have been reported. This short note is intended to summarize the significance of these findings and few remarkable controversies associated with them.

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“…Pioneer work by Gurdon et al . in 1962 demonstrated that the nuclei of mature intestine‐derived cells contain all the information necessary to generate a frog . In 2010, Nakauchi et al .…”

Section: Xenogeneic Chimera Generated By Blastocyst Complementationmentioning

confidence: 99%

Xenotransplantation: back to the future?

et al. 2018

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The field of xenotransplantation has fluctuated between great optimism and doubts over the last 50 years. The initial clinical attempts were extremely ambitious but faced technical and ethical issues that prompted the research community to go back to preclinical studies. Important players left the field due to perceived xenozoonotic risks and the lack of progress in pig-to-nonhuman-primate transplant models. Initial apparently unsurmountable issues appear now to be possible to overcome due to progress of genetic engineering, allowing the generation of multiple-xenoantigen knockout pigs that express human transgenes and the genomewide inactivation of porcine endogenous retroviruses. These important steps forward were made possible by new genome editing technologies, such as CRISPR/Cas9, allowing researchers to precisely remove or insert genes anywhere in the genome. An additional emerging perspective is the possibility of growing humanized organs in pigs using blastocyst complementation. This article summarizes the current advances in xenotransplantation research in nonhuman primates, and it describes the newly developed genome editing technology tools and interspecific organ generation.

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The Egg and the Nucleus: A Battle for Supremacy (Nobel Lecture)

Abstract: Figure 12. Nuclei from differentiated cells (mouse thymus) are reprogrammed much more slowly than embryo nuclei. Cell Reprogramming

Cited by 13 publications

References 50 publications

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

Physiology and Medicine: The Gifted Saga of the Last Decade

Xenotransplantation: back to the future?

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