Three-dimensional digital visible heart model and myocardial pathological characteristics of fetal single ventricle connected with aortic coarctation

Ren, Bing; Jiang, Yan; Xia, Hongmei; Li, X Y; Tan, Li; Li, Y; Li, Q Y; Li, X S; Gao, Yunhua

doi:10.4238/2013.october.30.9

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In some congenital heart diseases, in addition to abnormal cardiac anatomy, myocardial histopathological changes can be discerned at an early developmental stage during the fetal period; such changes include noncompaction, fibrosis, and endocardial fibroelastosis (EFE) [ 16 ]. The changes in the histological characteristics of the myocardium and great vascular wall in fetuses with a single ventricle connected to the aortic coarctation are obvious and may be the critical cause that leads to progressive dysfunction in the postnatal heart [ 17 ]. Noncompaction and EFE have previously been detected by fetal echocardiography, and contemporary diagnostic criteria have been established [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome

Jiang

Tang

et al. 2016

BioMed Research International

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Aims. To detect anatomical and intrinsic histopathological features of the ascending aorta and left ventricular (LV) myocardium and evaluate right ventricular (RV) function in fetuses with hypoplastic left heart syndrome (HLHS). Methods. Twenty-five fetuses diagnosed with HLHS were followed up in the antenatal and postpartum periods. 12 necropsy heart specimens were analyzed for morphological and histological changes. Results. Prenatal echocardiography and pathologic anatomy displayed the typical characteristics of HLHS as a severe underdevelopment of the LV in the form of mitral stenosis or atresia or as aortic atresia or stenosis, with a decreased ratio of aortic diameter to pulmonary artery diameter (median of 0.49 with a range of 0.24 to 0.69, p ≤ 0.001) and a higher ratio of RV diameter to LV diameter (median of 2.44 with a range of 1.33 to 6.25, p ≤ 0.001). The RV volume, stroke volume, and cardiac output in HLHS fetuses were increased compared with the gestational age-matched normal controls (p < 0.01). Histological changes in the 12 HLHS specimens included LV myocardial fibrosis, aortic elastic fragmentation, and fibrosis. Conclusions. In addition to severe anatomical deformity, distinct histological abnormalities in the LV myocardium and aortic wall were identified in the fetuses with HLHS. RV function damage may be potentially exists.

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Section: Discussionmentioning

confidence: 99%

Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome

Jiang

Tang

et al. 2016

BioMed Research International

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“…Multiple CT cross-sectional images of fetal hearts have been used to reconstruct digital images of a normal heart as well as single ventricle and coarctation of the aorta. [ 7 , 8 ]. However, the educational goal of this reconstruction was mostly limited to surgical planning.…”

Section: Introductionmentioning

confidence: 99%

3D models improve understanding of congenital heart disease

et al. 2021

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Introduction Understanding congenital heart disease (CHD) is vital for medical personnel and parents of affected children. While traditional 2D schematics serve as the typical approach used, several studies have shown these models to be limiting in understanding complex structures. Recent world-emphasis has shifted to 3D printed models as a complement to 2D imaging to bridge knowledge and create new opportunities for experiential learning. We sought to systematically compare 3D digital and physical models for medical personnel and parent education compared to traditional methods. Methods 3D printed and digital models were made out of MRI and CT data for 20 common CHD. Fellows and nurse practitioners used these models to explore intra-cardiac pathologies following traditional teaching. The models were also used for parent education in outpatient settings after traditional education. The participants were then asked to fill out a Likert scale questionnaire to assess their understanding and satisfaction with different teaching techniques. These ratings were compared using paired t-tests and Pearson’s correlation. Results Twenty-five medical personnel (18 fellows; 2 nurses; 4 nurse practitioners and one attending) and twenty parents participated in the study. The diagnosis varied from simple mitral valve pathology to complex single ventricle palliation. Parent and medical personnel perceived understanding with digital models was significantly higher than traditional (p = 0.01). Subjects also felt that physical models were overall more useful than digital ones (p = 0.001). Physicians using models for parent education also perceived the models to be useful, not significantly impacting their clinical workflow. Conclusions 3D models, both digital and printed, enhance medical personnel and parental perceived understanding of CHD.

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“…Caregivers rated their understanding and satisfaction as "signi cantly improved" using this modality. Wang et al describe the use of multiple CT cross-sectional images of fetal hearts to reconstruct a digital image of a normal heart while Ren et al recount how single ventricle and coarctation of the aorta can be more effectively visualized through 3D digital reconstruction [7,8]. However, the educational goal of this reconstruction was mostly limited to surgical planning.…”

Section: Introductionmentioning

confidence: 99%

3D Models Improve Understanding of Congenital Heart Disease

Awori

Friedman

Chan

et al. 2020

Preprint

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Introduction: Understanding congenital heart disease (CHD) is vital for medical personnel and parents of affected children. While traditional 2D schematics serve as the typical approach used, several studies have shown these models to be suboptimal. Recent world-emphasis has shifted to 3D printed models to bridge knowledge and create new opportunities for experiential learning. We sought to systematically compare 3D digital and physical models for medical personnel and parent education compared to traditional methods.Methods: 3D printed and digital models were made out of MRI and CT data for 20 common CHD. Fellows and nurse practitioners used these models to explore intra-cardiac pathologies following traditional teaching. The models were also used for parent education in outpatient settings after traditional education. The participants were then asked to fill out a Likert scale questionnaire to assess their understanding and satisfaction with different teaching techniques. These ratings were compared using paired t-tests and Pearson’s correlation. Results: Twenty-five medical personnel (18 fellows; 2 nurses; 4 nurse practitioners and one attending) and twenty parents participated in the study. The diagnosis varied from simple mitral valve pathology to complex single ventricle palliation. Parent and medical personnel understanding with digital models was significantly higher than traditional (p = 0.01). Subjects also felt that physical models were overall more useful than digital ones (p=0.001). Physicians using models for parent education also perceived the models to be useful, not significantly impacting their clinical workflow.Conclusions: 3D models, both digital and printed, enhance medical personnel and parental understanding of CHD.

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Three-dimensional digital visible heart model and myocardial pathological characteristics of fetal single ventricle connected with aortic coarctation

Cited by 4 publications

References 20 publications

Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome

Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome

3D models improve understanding of congenital heart disease

3D Models Improve Understanding of Congenital Heart Disease

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