Activity of ceftaroline against community associated and healthcare associated methicillin resistant Staphylococcus aureus

Coombs, Geoffrey W.; Pearson, Julie; Robinson, James O.; Christiansen, Keryn

doi:10.1097/pat.0000000000000032

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Strikingly, ST93-MRSA-IVa was not detected in Western Australia until 2003. However, since then ST93-MRSA-IVa has become the dominant CA-MRSA in Western Australia, with a focus in the north-west of the state, particularly the Kimberley region where ST93-MRSA has been isolated at a rate of 2,499 isolations per 100,000 population in 2015–2016 (compared to 41 isolations per 100,000 population in the metropolitan region around the capital Perth) ( Coombs et al, 2017 ). As with the emergence of ST93-MSSA, it is likely that socio-demographic factors play an important role in this rapid expansion of ST93-MRSA-IVa.…”

Section: Discussionmentioning

confidence: 99%

Global Scale Dissemination of ST93: A Divergent Staphylococcus aureus Epidemic Lineage That Has Recently Emerged From Remote Northern Australia

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome sequences from Australia, New Zealand, Samoa, and Europe to investigate the evolutionary history of ST93, its emergence in Australia and subsequent spread overseas.Results: Comparisons with other S. aureus genomes indicate that ST93 is an early diverging and recombinant lineage, comprising of segments from the ST59/ST121 lineage and from a divergent but currently unsampled Staphylococcal population. However, within extant ST93 strains limited genetic diversity was apparent with the most recent common ancestor dated to 1977 (95% highest posterior density 1973–1981). An epidemic ST93 population arose from a methicillin-susceptible progenitor in remote Northern Australia, which has a proportionally large Indigenous population, with documented overcrowded housing and a high burden of skin infection. Methicillin-resistance was acquired three times in these regions, with a clade harboring a staphylococcal cassette chromosome mec (SCCmec) IVa expanding and spreading to Australia’s east coast by 2000. We observed sporadic and non-sustained introductions of ST93-MRSA-IVa to the United Kingdom. In contrast, in New Zealand, ST93-MRSA-IVa was sustainably transmitted with clonal expansion within the Pacific Islander population, who experience similar disadvantages as Australian Indigenous populations.Conclusion: ST93 has a highly recombinant genome including portions derived from an early diverging S. aureus population. Our findings highlight the need to understand host population factors in the emergence and spread of antimicrobial resistant community pathogens.

show abstract

Section: Discussionmentioning

confidence: 99%