Abstract:The complement system is an integral component of the innate immune response and plays a vital role in adaptive immunity. Activation of the system produces peptide fragments, such as C5a, that target G-protein coupled receptors expressed on immune-related cells, such as macrophages, that initiate pro-inflammatory responses. We have discovered that the C5a receptor 1 (C5aR1) is also expressed in skeletal muscle, a primary insulin target tissue. Sustained exposure of muscle cells to palmitate (PA), a saturated f… Show more
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