Productos homeopáticos: la importancia de una correcta información

Sanguos, C. López; Morin, M; López, P. Vázquez

doi:10.1016/j.anpedi.2013.10.012

Anales de Pediatría

2014

DOI: 10.1016/j.anpedi.2013.10.012

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Productos homeopáticos: la importancia de una correcta información

C. López Sanguos

M Morin

P. Vázquez López

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Cited by 5 publications

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“…1 Recent cases of side effects of homeopathic products have been reported, especially in children. 15,16 The US Food and Drug Administration (FDA) has also reported cases of adverse effects (including infant deaths) because of the use of teething products obtained from Belladonna, 17 due to abnormally high concentrations of tropane alkaloids. Although to our knowledge, there are no studies of tropane alkaloids in homeopathic products or drugs, most of the studies developed in other matrices only focus on the determination of atropine and scopolamine, 18,19 despite other potential dangerous tropane alkaloids such as anisodamine or homatropine are present in Solanaceae plants.…”

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confidence: 99%

Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis

Marín-Sáez

Romero-González

Frenich

et al. 2018

Drug Testing and Analysis

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Homeopathic products are still a controversial issue in modern medicine, understood as complementary or alternative medicine (CAM). In this particular case, homeopathic products prepared from Atropa belladonna extracts may present specific problems due to the effects derived from its components. This article applies a simple, rapid, reliable method to the analysis of different homeopathic products obtained from Atropa belladonna; drugs containing high concentration of plant extracts; and Atropa belladonna seeds. The method was based on a simple solid-phase preconcentration method followed by ultra-high pressure liquid chromatography (UHPLC) coupled to high resolution mass spectrometry using Exactive-Orbitrap as an analyser. An in-house database was set and atropine and scopolamine were the compounds detected at highest concentrations in homeopathic products from Atropa belladonna extracts (4.57 and 2.56 μg/kg, respectively), in Belladonna ointment (4007 and 1139 μg/kg, respectively) and Belladonna seeds (338 and 32.1 mg/kg, respectively). Other tropane alkaloids such as tropine, apoatropine, aposcopolamine, tropinone, homatropine, and anisodamine were detected at lower concentrations (0.04-1.36 μg/kg). When untargeted analysis was performed, other tropane alkaloids were identified in the tested samples, such as ecgonine (0.003 μg/kg), benzoylecgonine (0.56 μg/kg), calystegines A (19.6 μg/kg), B (33.1 μg/kg), and C (1.01 μg/kg). Finally other compounds present in the homeopathic products, such as sugars (fructose, glucose, and lactose) or amino acids (valine, ornithine, leucine, and phenylalanine), were identified.

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mentioning

confidence: 99%

Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis

Marín-Sáez

Romero-González

Frenich

et al. 2018

Drug Testing and Analysis

View full text Add to dashboard Cite

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Position statement from the Spanish Association of Paediatrics Medicines Committee concerning the use of alternative medicine and pseudo-science in children

Pérez

Cuadros

Marrodán

et al. 2019

Anales de Pediatría (English Edition)

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Results of a national survey on knowledge and use of complementary and alternative medicine by paediatricians

Pérez

Cuadros

García

et al. 2022

Anales de Pediatría (English Edition)

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Productos homeopáticos: la importancia de una correcta información

Cited by 5 publications

References 4 publications

Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis

Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis

Position statement from the Spanish Association of Paediatrics Medicines Committee concerning the use of alternative medicine and pseudo-science in children

Results of a national survey on knowledge and use of complementary and alternative medicine by paediatricians

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