Acute exercise-induced activation of Phox2b-expressing neurons of the retrotrapezoid nucleus in rats may involve the hypothalamus

Barna, Bárbara; Takakura, Ana C.; Moreira, Thiago S.

doi:10.1016/j.neuroscience.2013.11.031

Cited by 43 publications

(32 citation statements)

References 56 publications

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“…Several studies indicate that the periaqueductal gray (PAG) and the rostral ventromedial medulla (RVM) constitute the outflow of descending modulation and that peripheral damage can alter the balance between inhibition and facilitation of nociception by these brainstem structures (Niesters et al, 2013; De Felice et al, 2011; Heinricher et al, 2009; Vanegas and Schaible, 2004). The LH sends projections to both the PAG (Clement et al, 2012; Hsieh et al, 2011; Holden et al, 2009) and RVM (Barba, et al, 2014; Holden et. al., 2005; Herman, et al, 1997) as well as the descending noradrenergic neurons in the dorsolateral pontine tegmentum (Tokita et al, 2009; Holden and Naleway, 2000; Holden, et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

et al. 2014

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“…According to our previous publications (Barna et al . ; Takakura et al . ), the brains were removed from the skull, cryoprotected by overnight immersion in a 20% sucrose solution in phosphate‐buffered saline at 4°C, sectioned in the coronal plane at 40 μm on a sliding microtome and stored in cryoprotectant solution (20% glycerol plus 30% ethylene glycol in 50 m m phosphate buffer, pH 7.4) at −20°C for up to 2 weeks while awaiting histological processing.…”

Section: Methodsmentioning

confidence: 99%

“…All histochemical procedures were done using free‐floating sections according to previously described protocols (Barna et al. , ).…”

Section: Methodsmentioning

confidence: 99%

Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy

Totola

Takakura

Oliveira

et al. 2016

The Journal of Physiology

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Respiratory disorders may involve changes in serotonergic neurotransmission at the level of the chemosensitive neurons located in the retrotrapezoid nucleus (RTN). Here, we investigated the central respiratory chemoreflex and the role of serotonergic neurotransmission in the RTN with a rat model of tonic-clonic seizures, the Wistar audiogenic rat (WAR). We found that naive or kindled WARs have reduced resting ventilation and ventilatory response to hypercapnia (7% CO ). The number of chemically coded (Phox2b /TH ) RTN neurons, as well as the serotonergic innervation to the RTN, was reduced in WARs. We detected that the ventilatory response to serotonin (1 mm, 50 nl) within the RTN region was significantly reduced in WARs. Our results uniquely demonstrated a respiratory impairment in a genetic model of tonic-clonic seizures, the WAR strain. More importantly, we demonstrated an overall decrease in the number of neurons located in the ventral respiratory column (VRC), as well as a reduction in serotonergic neurons in the midline medulla. This is an important step forward to demonstrate marked changes in neuronal activity and breathing impairment in the WAR strain, a genetic model of epilepsy.

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“…The RTN chemo sensors also appear to serve as important sites of integration of several stimuli, as these neurons are significantly modulated by inputs from vagally mediated pulmonary stretch receptors and from the hypothalamus[122]. Recent evidence (using c–FOS immunoreactivity) also shows these RTN Phox2b neurons to be activated by acute exercise in the rodent [9] – indirectly suggesting potential participation of the RTN chemosensitive neurons in the “central command” stimulus to exercise hyperpnea (also see Exercise Hyperpnea section below).…”

Section: Chemoreceptionmentioning

confidence: 99%

Pathophysiology of human ventilatory control

2014

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We review the substantial progress recently made in understanding the underlying mechanisms controlling breathing and the applicability of these findings to selected human diseases. Emphasis is placed on the sites of central respiratory rhythm and pattern generation as well as newly described functions of the carotid chemoreceptors and the integrative nature of the central chemoreceptors and the interaction between peripheral and central chemoreception. Recent findings supporting critical contributions from cortical central command and muscle afferent feedback to exercise hyperpnea are also reviewed. These basic principles and the evidence supporting chemoreceptor and ventilatory control system plasticity during and following constant and intermittent hypoxemia and stagnant hypoxia are applied: a) to the pathogenesis, consequences and treatment of obstructive sleep apnea; and b) to exercise hyperpnea and its control and limitations with aging, COPD and CHF.

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Acute exercise-induced activation of Phox2b-expressing neurons of the retrotrapezoid nucleus in rats may involve the hypothalamus

Cited by 43 publications

References 56 publications

Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy

Pathophysiology of human ventilatory control

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