Effect of Proline-Rich Synthetic Peptide–Coated Titanium Implants on Bone Healing in a Rabbit Model

Abstract

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Proline‐Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing

“…38 The only in vivo model assessing the bioactivity of P2 investigated the influence of P2 peptide-coated implants on bone healing. 19 P2 failed to promote osseointegration, although it is likely that the study was underpowered with a small sample size.…”

“…The activity of the 45-amino acid fragment of amelogenin (TRAP) might be related to the observed early anti-inflammatory effect of EMD. In addition, in a rabbit model, Petzold et al 19 found a trend toward a reduced expression of genes related to pro-inflammatory cytokines and the osteoclastic marker tartrate-resistant acid phosphatase in bone tissue attached to P2-coated implants. 19 These observations require further studies to elucidate the mechanisms behind these in vivo effects.…”

“…Proline‐rich peptides have been shown to have antimicrobial properties, are related to the immune response, and are claimed to be involved in wound repair 38 . The only in vivo model assessing the bioactivity of P2 investigated the influence of P2 peptide–coated implants on bone healing 19 . P2 failed to promote osseointegration, although it is likely that the study was underpowered with a small sample size.…”

“…Amelogenins exhibit proline‐rich regions and belong to a family of intrinsically disordered proteins with a well‐known regulatory role in an important biologic process, biomineralization 16 . Polyproline‐rich synthetic peptides have previously been shown to promote mesenchymal stem cell differentiation, induce bone formation and mineralization in vitro, 17 , 18 and decrease bone resorption in vivo 19 , 20 . There is interest in finding synthetic peptides that can substitute for natural peptides used in medicine because of their ease of synthesis and low immunogenic activity.…”

Implantatoberflächen und ihr Einfluss auf das periimplantäre Hartgewebe

“…Polyprolinreiche synthetische Peptide konnten die mRNA-Expression der Osteoblastenmarker Osteokalzin und Osteopontin steigern [84]. Eine Kaninchenstudie zeigte, dass die mRNA-Expression tartratresistenter saurer Phosphatase, eines Knochenabbaumarkers, signifikant reduziert war, während sich die Osteokalzinexpression im periimplantären Gewebe erhöh-te [85].…”