BackgroundIndividuals recently released from prison engage in risky behaviors that predispose them to contracting HIV. Women may be at increased risk in the immediate period post-release, given higher rates of poverty, food insecurity, and substance dependence and lower educational attainment compared with men.MethodsWe describe gender differences in HIV risk behaviors using validated measures and assess potential mediators of this relationship using data from a cross-sectional study of 109 individuals recently released from prison.ResultsWomen had higher rates of HIV drug-related risk behaviors compared with men (mean score 2.72 vs. 0.068; p = .003) and HIV sex-related risk behaviors (mean score 4.32 vs. 2.31; p = .016). Women also had higher mean incomes and severity of drug and alcohol use compared with men, but equally high rates of food insecurity and low levels of AIDS knowledge. In multivariate analysis, the relationship between gender and HIV drug-related and sex-related risk behaviors was attenuated by a greater monthly income ([drug] adjusted β 0.82, 95% CI -1.02 – 2.66, p = 0.38; [sex] adjusted β 0.75, 95% CI -1.04 – 2.54, p = 0.41), as well as severity of drug use ([drug] adjusted β 0.79, 95% CI -0.55 – 2.13, p = 0.24; [sex] adjusted β 0.09, 95% CI -1.17 – 1.35, p = 0.89).ConclusionsWomen had higher rates of HIV risk behaviors compared with men post-release. Gender specific interventions may be useful in reducing risky drug-related and sex-related behaviors in the period immediately following release.