Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

Abstract

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy was effective and safe in the treatment of gingival carcinoma. This treatment may be a promising curative and organ-preserving treatment option for gingival carcinoma.

Impact of Superselective Intra-Arterial and Systemic Chemoradiotherapy for Gingival Carcinoma; Analysis of Treatment Outcomes and Prognostic Factors

“…According to our previously published study [1], patients received external irradiation at a planned total dose of 60-70 Gy in 30-35 fractions using three-dimensional RT. Fraction size was 2 Gy and was delivered daily, 5 days per week, using 6 MV Xrays and a shrinking eld technique.…”

“…Oral cancers are the 6th most common malignancy, comprising 1-3% of all malignancies. In Japan, gingival carcinoma (GC) is more common than in Western countries [1][2][3][4][5][6][7]. Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a well-established treatment for GC [2,8,9].…”

“…Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a well-established treatment for GC [2,8,9]. Other treatment options for oral cancers are combinations of radiation therapy (RT) including external beam RT and brachytherapy, and chemotherapy; these are considered to be organ-preserving treatments [1,6,8,10].…”

“…Although we previously investigated outcomes of RT with concurrent retrograde super-selective IACRT for GC [1], there are few studies of CRT for GC. The best means of administering chemotherapy in this setting is unclear.…”

“…This analysis therefore compared outcomes and toxicity between RT with concurrent retrograde super-selective IACRT, and RT with concurrent systemic chemotherapy for GC. To do so, we included patients who were studied in a previously published investigation [1].…”