Do placental histologic findings of chorion-decidual hemorrhage or inflammation in spontaneous preterm birth influence outcomes in the subsequent pregnancy?

Hackney, David; Tirumala, Radhika; Salamone, Linda; Miller, Richard K.; Katzman, Philip J.

doi:10.1016/j.placenta.2013.11.001

Cited by 15 publications

(12 citation statements)

References 16 publications

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“…In our cases, spontaneous abortion observed in 25% among them, whereas incomplete abortion ranked the majority of cases and found in 42.5% and unfortunately 5% of cases were related to trauma. A study was performed by [11] they reported 39.7% had spontaneous abortion at >20 weeks gestational age at his institution.…”

Section: Discussionmentioning

confidence: 99%

Anatomical and Histopathologic Analysis of Placenta in Dilation and Evacuation Specimens

Hassan¹,

Hegazy²,

Mosaed³

2014

FMAR

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Background: Anatomical and histopathologic examination of placenta in cases of abortion is crucial as to clarify the underlying causes of many adverse pregnancy outcomes. Dilation and evacuation (D&E) is the most common mode of uterine evacuation that commonly examined in pathology sections. The aim of this study is to discuss the various placental pathologies, and to demonstrate the importance of careful pathologic examination of D&E material, also to review the anatomy of placenta and to compare our findings with other publications worldwide. Material and Methods: A retrospective descriptive study for 200 placental tissues was collected in 18 months period and revised for normal anatomy and various placental pathologies. These placentas were obtained by dilation and evacuation (D&E) technique. All cases were undergone for histopathological sections that were stained by Hematoxylin and Eosin (H&E). Results: Placental infarction was observed in 25% of cases, and chorioammnitis was the most common form of placental infection and found in 12.5%. Molar changes were represented a lowered percentage of placental pathologies that found in 9% of specimens. Conclusion: Study and recognition of placental lesions among general surgical pathologists have clinical significance and awareness of deficiency, standardization of diagnostic criteria, and increased knowledge in placental pathology improve the quality of diagnosis in this area.

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Section: Discussionmentioning

confidence: 99%

Anatomical and Histopathologic Analysis of Placenta in Dilation and Evacuation Specimens

Hassan¹,

Hegazy²,

Mosaed³

2014

FMAR

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“…Other factors known to contribute to the aetiology of preterm birth that are not amenable to primary prevention include the presence of functional polymorphisms in genes present in the mother and/or fetus that determine the direction and magnitude of proinflammatory immune responses 8 and decidual haemorrhage due to known or unknown causes. 9 There are conflicting reports as to whether the haematogenous dissemination of bacteria to the amniotic cavity from women with periodontal disease increases the rate of preterm birth and whether appropriate dental treatment can improve pregnancy outcome. 10 A consistent observation is the racial difference in the rate of preterm birth.…”

Section: Primary and Secondary Preventionmentioning

confidence: 99%

The vaginal microbiome, vaginal anti‐microbial defence mechanisms and the clinical challenge of reducing infection‐related preterm birth

Witkin

2014

BJOG

139

108

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Ascending bacterial infection is implicated in about 40-50% of preterm births. The human vaginal microbiota in most women is dominated by lactobacilli. In women whose vaginal microbiota is not lactobacilli-dominated anti-bacterial defence mechanisms are reduced. The enhanced proliferation of pathogenic bacteria plus degradation of the cervical barrier increase bacterial passage into the endometrium and amniotic cavity and trigger preterm myometrial contractions. Evaluation of protocols to detect the absence of lactobaciili dominance in pregnant women by self-measuring vaginal pH, coupled with measures to promote growth of lactobacilli are novel prevention strategies that may reduce the occurrence of preterm birth in low-resource areas.

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“…In addition, in the present case, the placenta had multiple fibrin thromboses. Fibrin deposition has been reported to have a relation with placental abruption, and some cases of placental surface cysts tend to present with fibrin deposition on the placenta . Consequently, placental surface cysts might be believed to have a relation with placental abruption.…”

Section: Discussionmentioning

confidence: 99%

Multiple placental surface cysts with intracystic hemorrhaging: A case report and review of the literature

Soyama

Miyamoto

Sasa

et al. 2017

J of Obstet and Gynaecol

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A placental surface cyst is a cystic mass arising from the surface of the placenta. It is seldom complicated by intracystic hemorrhaging and the clinical importance of this kind of case is unclear. Therefore, we present a case of a placental surface cyst with intracystic hemorrhaging. A 29-year-old multiparous woman was diagnosed with multiple placental surface cysts with threatened preterm birth and fetal growth restriction on ultrasonography at 26 gestational weeks (GW). At 31 GW, the hemorrhage was identified inside the cyst. At 32 GW, she presented with placental abruption, and emergency cesarean section was performed. Both the mother and her baby survived. Placental surface cysts up to 77 × 65 mm in diameter containing old hemorrhages were discovered, and pathological examination revealed hemosiderin and fibrin deposition. Pregnancy with a placental surface cyst with intracystic hemorrhaging may have the potential for severe obstetric complications.

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Do placental histologic findings of chorion-decidual hemorrhage or inflammation in spontaneous preterm birth influence outcomes in the subsequent pregnancy?

Cited by 15 publications

References 16 publications

Anatomical and Histopathologic Analysis of Placenta in Dilation and Evacuation Specimens

Anatomical and Histopathologic Analysis of Placenta in Dilation and Evacuation Specimens

The vaginal microbiome, vaginal anti‐microbial defence mechanisms and the clinical challenge of reducing infection‐related preterm birth

Multiple placental surface cysts with intracystic hemorrhaging: A case report and review of the literature

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