Percutaneous Renal Cryoablation: Prospective Experience Treating 120 Consecutive Tumors

Abstract

Midterm follow-up shows that percutaneous renal cryoablation is an effective and safe alternative technique for patients whose condition does not allow surgery and that renal function is preserved. Cryoablation combined with percutaneous thermal protection techniques allows treatment of more complex tumors (large central tumors and tumors close to vulnerable structures). However, T1b and central tumors are associated with higher risk of incomplete treatment.

Computed Tomography Perfusion, Magnetic Resonance Imaging, and Histopathological Findings After Laparoscopic Renal Cryoablation: An In Vivo Pig Model

“…In contrast to nodular enhancement, which is highly suspicious for residual or recurrent tumor, rim enhancement has been observed to persist for several months before subsiding. [5][6][7]24 With respect to ablative treatment, imaging modalities are limited by resolution and uncertainty of the viability of cells within the peripheral zone, thus increasing the risk of over-and underreporting the true extent of disease control. 7,25,26 Computed tomography offers good spatial resolution (ability to distinguish 2 structures a small distance apart as separate) whereas MRI offers a comparable spatial resolution but with a far better contrast resolution for soft tissues (ability to distinguish the differences between 2 similar but not identical tissues, that is, distinguish between differences in signal intensity in an image).…”

Percutaneous cryoablation for inoperable malignant lung tumors: Midterm results

“…Minimally invasive procedure has been shown as an effective way for local treatment of malignancy in solid organ such as liver, prostate and kidney [1,3,14,17,20]. Despite surgery for early stage non-small cell lung cancer (NSCLC) and lung metastasectomy has good tumor control rate, many people are inoperable [31].…”

CT-Guided Percutaneous Cryoablation in Renal Cell Carcinoma: Factors Affecting Local Tumor Control

“…In patients who are not surgical candidates because of comorbidities or other conditions that preclude surgical intervention, RF ablation and cryoablation have emerged as useful therapeutic options for the treatment of RCC (1,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). The greatest benefit of image-guided cryoablation over RF ablation is the visualization of the ice ball, which reflects the therapeutic region during treatment, with computed tomography (CT) or magnetic resonance (MR) imaging (1,(9)(10)(11)(12)(13)(14)(15).…”

“…The greatest benefit of image-guided cryoablation over RF ablation is the visualization of the ice ball, which reflects the therapeutic region during treatment, with computed tomography (CT) or magnetic resonance (MR) imaging (1,(9)(10)(11)(12)(13)(14)(15). Tumor size and central location limit the efficacy and safety of RF ablation (6).…”

“…Tumor size and central location limit the efficacy and safety of RF ablation (6). Reported local tumor progression rates after cryoablation of small renal tumors vary in the range of 0%-23% during a mean follow-up period of 10-24 months (7)(8)(9)(10)(11)(12)(13)(14)(15). The size of the ice-ball margin was reported to be related to the avoidance of local tumor progression (16,17), and skin-totumor distance was reported as one of several factors affecting local tumor progression (13).…”