Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells

Zanin, Juan Pablo; Battiato, Natalia Laura; Rovasio, Roberto A.

doi:10.1016/j.ejcb.2013.10.006

Cited by 12 publications

(8 citation statements)

References 87 publications

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“…While TrkB/BDNF signalling is critical for synaptic function and plasticity, its role in chemotaxis 28 has been shown previously in the developing cortex and cerebellum in vitro 29 and in vivo 30 . BDNF is also required for target innervation and patterning of sensory innervation 31 32 33 .…”

Section: Discussionmentioning

confidence: 76%

TrkB/BDNF signalling patterns the sympathetic nervous system

et al. 2015

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The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that comprise a chain of vertebral sympathetic ganglia, arises developmentally is incompletely understood. This problem is especially complex given the vertebral chain of sympathetic ganglia derive secondarily from the dorsal migration of ‘primary' sympathetic ganglia that are initially located several hundred microns ventrally from their future pre-synaptic partners. Here we report that the dorsal migration of discrete ganglia is not a simple migration of individual cells but a much more carefully choreographed process that is mediated by extensive interactions of pre-and post-ganglionic neurons. Dorsal migration does not occur in the absence of contact with preganglionic axons, and this is mediated by BDNF/TrkB signalling. Thus BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system.

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Section: Discussionmentioning

confidence: 76%

TrkB/BDNF signalling patterns the sympathetic nervous system

et al. 2015

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“…The NCCs constitute an transient population accurately moving and undergoing a wide dispersion along multiple pathways, invading with precision defined sites of the embryo and differentiating into many derivatives ( Zanin et al, 2013 ). As reviewed by Vega-Lopez et al (2017) , NCCs are generated along the entire length of the anterior–posterior axis, with the exception of the most anterior part of the embryo.…”

Section: Roles Of P75 Ntr In Neural Crest Cell Migmentioning

confidence: 99%

From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion?

Wislet

Vandervelden

Rogister

2018

Front. Mol. Neurosci.

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The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest population, since p75NTR has been described as ubiquitously expressed and considered as a neural crest marker. Neural crest cells (NCCs) constitute an transient population accurately migrating and invading, with precision, defined sites of the embryo. During migration, NCCs are guided along distinct migratory pathways by specialized molecules present in the extracellular matrix or on the surfaces of those cells. Two main processes direct NCC migration during the development: (1) an epithelial-to-mesenchymal transition and (2) a process known as contact inhibition of locomotion. In adults, p75NTR remains expressed by NCCs and has been identified in an increasing number of cancer cells. Nonetheless, the regulation of the expression of p75NTR and the underlying mechanisms in stem cell biology or cancer cells have not yet been sufficiently addressed. The main objective of this review is therefore to analyze elements of our actual knowledge regarding p75NTR roles during the development (mainly focusing on neural crest development) and see how we can transpose that information from development to cancer (and vice versa) to better understand the link between p75NTR and cell migration and invasion. In this review, we successively analyzed the molecular mechanisms of p75NTR when it interacts with several coreceptors and/or effectors. We then analyzed which signaling pathways are the most activated or linked to NCC migration during the development. Regarding cancer, we analyzed the described molecular pathways underlying cancer cell migration when p75NTR was correlated to cancer cell migration and invasion. From those diverse sources of information, we finally summarized potential molecular mechanisms underlying p75NTR activation in cell migration and invasion that could lead to new research areas to develop new therapeutic protocols.

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“…Taken together, these studies suggested that NT-3 may possess the attractive effect towards the axons whether in the developing nervous system or nerve regeneration after injury [94]. Latest study also suggested that during the process of the cephalic neural crest cells (NCCs) invading the optic vesicle region in chick embryos, NT-3 was involved in this chemotactic guidance of NCCs [95].…”

Section: Attractive and Repulsive Molecular Cuesmentioning

confidence: 99%

A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways

et al. 2019

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A fundamental feature of both early nervous system development and axon regeneration is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. In the navigation process where the nerves grow toward their targets, the growth cones, which locate at the tips of axons, sense the environment surrounding them, including varies of attractive or repulsive molecular cues, then make directional decisions to adjust their navigation journey. The turning ability of a growth cone largely depends on its highly dynamic skeleton, where actin filaments and microtubules play a very important role in its motility. In this review, we summarize some possible mechanisms underlying growth cone motility, relevant molecular cues, and signaling pathways in axon guidance of previous studies and discuss some questions regarding directions for further studies.

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Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells

Cited by 12 publications

References 87 publications

TrkB/BDNF signalling patterns the sympathetic nervous system

TrkB/BDNF signalling patterns the sympathetic nervous system

From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion?

A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways

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